ABSTRACT
Several gain-of-function variants in NLRP1 cause a distinctive autoinflammatory disease reported under different names featuring mainly skin and mucosal involvement and variable systemic signs. Here, we report a new case of NLRP1-associated autoinflammatory disease in a 6-year-old Peruvian girl, who presented with confluent hyperkeratotic plaques that drained purulent material with subsequent scarring. A c.3641C > G (p. Pro1214Arg) variant that has been previously been reported was found in NLRP1 and was not present in either parent. The term NLRP1-associated autoinflammatory disease with epithelial dyskeratosis (NADED) is proposed to encompass all reported cases, which have received different nomenclature so far.
Subject(s)
Adaptor Proteins, Signal Transducing , Hereditary Autoinflammatory Diseases , Female , Humans , Child , Adaptor Proteins, Signal Transducing/metabolism , Apoptosis Regulatory Proteins/metabolism , Hereditary Autoinflammatory Diseases/diagnosis , Hereditary Autoinflammatory Diseases/genetics , Hereditary Autoinflammatory Diseases/complications , NLR ProteinsABSTRACT
INTRODUCCIÓN Y OBJETIVOS: La producción científica de las instituciones académicas constituye una medida relevante de su calidad. El objetivo del presente estudio fue analizar la producción científica de la Facultad de Medicina de la Universidad Nacional de Trujillo en las bases de datos MEDLINE/PubMed y SCOPUS hasta junio de 2016. MATERIAL Y MÉTODOS: Se realizó un estudio bibliométrico en las bases de datos MEDLINE/PubMed y SCOPUS, recuperándose los artículos publicados hasta junio de 2016 que consignaron al menos un autor con la filiación «Facultad de Medicina de la Universidad Nacional de Trujillo» o alguna institución perteneciente a la misma. Se extrajeron los siguientes datos: tipo de publicación, título, autor principal, coautores, autor para la correspondencia, filiaciones pertenecientes, año de publicación, idioma, revista y base de datos indexada. RESULTADOS: Se encontraron 54 publicaciones (43 en SCOPUS, 39 en Pubmed y 28 en ambas). Las publicaciones incluyeron 15 reportes de caso, 10 cartas al editor y 29 artículos originales publicados en 21 revistas, 2 de ellas fueron peruanas. El 16,7% (9/43) de las publicaciones fueron realizadas en el idioma inglés. Se registraron un total de 39 autores con filiación «Facultad de Medicina de la Universidad Nacional de Trujillo». CONCLUSIÓN: La producción científica de la Facultad de Medicina de la Universidad Nacional de Trujillo en MEDLINE/Pubmed y SCOPUS es baja. Es necesaria la implementación de estrategias que fomenten la producción científica involucrando a estudiantes, docentes, autoridades y egresados, así como la instauración de redes de colaboración que complementen las estrategias implementadas por CONCYTEC
INTRODUCTION AND OBJECTIVES: The study of scientific production from academic institutions is an important indicator of their quality. The aim of this study was to analyse the scientific production of the Faculty of Medicine of the National University of Trujillo using MEDLINE/PubMed and SCOPUS databases up to June 2016. MATERIAL AND METHODS: A literature review was performed using MEDLINE/PubMed and SCOPUS databases. An analysis was made of all articles published up to June 2016, with at least one author affiliated to Faculty of Medicine of the National University of Trujillo or its associated institutions. The following data were collected: type of publication, title, main author, co-authors, corresponding author, area of medicine, publication year, language, journal, and database. RESULTS: A total of 54 articles were indexed (43 in SCOPUS, 39 in PubMed, and 28 in both). Publication types included 15 case reports, 10 letters to the editor and 29 original articles. The articles were published in 21 journals, including 2 Peruvian journals, and 16.7% (9/43) of them were written in English. The Faculty of Medicine of the National University of Trujillo affiliation was used by 39 authors. CONCLUSION: The scientific production of the Faculty of Medicine of the National University of Trujillo indexed in MEDLINE/PubMed and SCOPUS is low. There is a need to establishment collaborative networks and strategies to promote scientific production involving students, teachers, authorities and graduates, and which complement the strategies implemented by CONCYTEC
Subject(s)
Science, Technology and Innovation Indicators , Schools, Medical/statistics & numerical data , Bibliometrics , Peru , MEDLINE/statistics & numerical data , PubMed/statistics & numerical dataSubject(s)
Mass Media/standards , Social Perception , Truth Disclosure , Adult , Female , Humans , Latin America , Peru , Social MediaABSTRACT
OBJECTIVE: To determine the effect of treatment with honey in piroxicam-induced gastric ulcer in Holtzman rats. MATERIALS AND METHODS: 48 eight-week old female Holtzman rats, weights between 100 and 200 grams, were divided into 6 treatment groups as follow: Group A: water; Group B: piroxicam (30 mg/kg); Group C: omeprazole (5 mg/kg) and piroxicam (30 mg/kg); Group D: honey (2.5 g/kg) and piroxicam (30 mg/kg); Group E: honey (5 g/kg) and piroxicam (30 mg/kg); Group F: honey (7.5 g/kg) and piroxicam (30 mg/kg). Macroscopic studies, using Scion Image, and microscopic histological section of gastric mucosa were performed after the interventions. RESULTS: The results of the macroscopic studies showed statistically significant differences for both doses of honey at 6 g/kg and 7.5 g/kg when compared to piroxicam (p=0.016 and p=0.001 respectively) and the gastroprotective effect was similar when compared to omeprazole (p>0.05). Microscopic studies showed statistically significant differences only for dose at 7.5 g/kg when compared to piroxicam (p=0.0018) and the gastroprotective effect was similar to omeprazole (p=1). CONCLUSION: Dose of honey at 7.5 g/kg showed gastroprotective effect at microscopic and macroscopic studies when compared to omeprazole.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Honey , Piroxicam/adverse effects , Stomach Ulcer/prevention & control , Animals , Anti-Ulcer Agents/therapeutic use , Female , Omeprazole/therapeutic use , Random Allocation , Rats , Rats, Sprague-Dawley , Stomach Ulcer/chemically induced , Treatment OutcomeABSTRACT
Objetivo: Determinar el efecto de la miel de abeja sobre úlceras gástricas inducidas por piroxicam en ratas Holtzman. Material y método: Se trabajó con 48 ratas hembra Holtzman de ocho semanas de edad con pesos entre 100 y 200 g, divididas en 6 grupos, con las siguientes intervenciones: Grupo A: agua; Grupo B: piroxicam (30 mg/kg); Grupo C: omeprazol (5 mg/kg) y piroxicam (30 mg/kg); Grupo D: miel (2,5 g/kg) y piroxicam (30 mg/kg); Grupo E: miel (5 g/kg) y piroxicam (30 mg/kg); Grupo F: miel (7,5 g/kg) y piroxicam (30 mg/kg). Luego de las intervenciones se realizaron estudios macroscópicos de las lesiones de la mucosa gástrica mediante el paquete Scion Image® y microscópicos, por estudio histológico. Resultados: El estudio macroscópico determinó que la miel a dosis de 5 g/kg y 7,5 g/kg se asoció a úlceras gástricas significativamente menores que el piroxicam (p=0,016 y p=0,001 respectivamente); por otro lado, el efecto gastroprotector de ambas dosis fue similar al omeprazol (p>0,05). En el estudio microscópico, se halló que solo la miel a dosis de 7,5 g/kg tuvo lesiones significativamente menores al piroxicam (p=0,0018), además que el efecto gastroprotector fue similar al omeprazol (p=1). Conclusiones: La miel a dosis 7,5 g/kg mostró un efecto gastroprotector similar al del omeprazol tanto a nivel macroscópico y microscópico. La miel a dosis de 5 g/kg tuvo un efecto gastroprotector similar al omeprazol, solo a nivel macroscópico.
Objective: To determine the effect of treatment with honey in piroxicam-induced gastric ulcer in Holtzman rats. Materials and methods: 48 eight-week old female Holtzman rats, weights between 100 and 200 grams, were divided into 6 treatment groups as follow: Group A: water; Group B: piroxicam (30 mg/kg); Group C: omeprazole (5 mg/kg) and piroxicam (30 mg/kg); Group D: honey (2.5 g/kg) and piroxicam (30 mg/kg); Group E: honey (5 g/kg) and piroxicam (30 mg/kg); Group F: honey (7.5 g/kg) and piroxicam (30 mg/kg). Macroscopic studies, using Scion Image, and microscopic histological section of gastric mucosa were performed after the interventions. Results: The results of the macroscopic studies showed statistically significant differences for both doses of honey at 6 g/kg and 7.5 g/kg when compared to piroxicam (p=0.016 and p=0.001 respectively) and the gastroprotective effect was similar when compared to omeprazole (p>0.05). Microscopic studies showed statistically significant differences only for dose at 7.5 g/kg when compared to piroxicam (p=0.0018) and the gastroprotective effect was similar to omeprazole (p=1). Conclusion: Dose of honey at 7.5 g/kg showed gastroprotective effect at microscopic and macroscopic studies when compared to omeprazole.
