ABSTRACT
UNLABELLED: The aim of our work was to evaluate changes in regional cerebral blood flow (rCBF) in patients with TIA and/or completed stroke and localisation of fotopenic foci in basal conditions and, in some cases, after stimulation pharmacological trial with acetazolamide. One hundred and fifty three patients participated in the study--105 with completed stroke and 48 with TIA. Regional CBF (rCBF) was evaluated using a single-headed rotating gamma camera (Diacam, Siemens) with high resolution collimator, after injection of 740 MBq 99mTc-HMPAO (Ceretec, Amersham). Sixteen patients with TIA underwent SPECT at baseline and after injection of acetazolamide (ACZ). Relative regional perfusion was expressed as the ratio of cerebral/cerebellar activity. In the completed stroke population, the perfusion ratios were significantly lower than those of controls and TIA at baseline (p < 0.001) and TIA after ACZ (p < 0.01). CONCLUSIONS: This study shows a significant difference in rCBF in patients with completed stroke and/or TIA and controls. In patients with TIA and rCBF similar to that observed in controls, perfusion deficits may be visible after ACZ injection.
Subject(s)
Brain/blood supply , Ischemic Attack, Transient/diagnosis , Tomography, Emission-Computed, Single-Photon , Adult , Aged , Aged, 80 and over , Brain/physiopathology , Cerebrovascular Circulation/physiology , Female , Functional Laterality/physiology , Humans , Ischemic Attack, Transient/physiopathology , Male , Middle Aged , Oximes , Radiopharmaceuticals , Severity of Illness IndexABSTRACT
The great concern exists that new variant of CJD (nvCJD) developed as a result of exposure to bovine spongiform encephalopathy (BSE)-infected meat products. Therefore, all cases of CJD in the young, as the one of ours are the matter of interest. The 21-year-old female developed a rapid progression of pyramidal, extrapyramidal and cerebellar signs, visual loss and psychiatric symptoms, leading to death in 16 weeks. The microscopic features were: a neuronal loss accentuated in cerebral cortex with extensive astroglia proliferation and spongiform changes. Immunohistochemical staining, revealed the presence of "synaptic" deposits of PrP in the cerebral cortex and in the cerebellum. No florid amyloid plaques were present. The case was diagnosed as a sporadic CJD, with some features of Heidenhein variant (visual symptoms) and corticostriatocerebellar category. The pathological findings excluded a nv CJD which is linked with BSE.
Subject(s)
Creutzfeldt-Jakob Syndrome , Adult , Brain/pathology , Creutzfeldt-Jakob Syndrome/diagnosis , Creutzfeldt-Jakob Syndrome/pathology , Diagnosis, Differential , Diet, Vegetarian , Education, Veterinary , Encephalopathy, Bovine Spongiform , Fatal Outcome , Female , Humans , Risk Factors , Students, Health OccupationsABSTRACT
Regional cerebral blood flow in SPECT pattern was estimated in 20 cases of Alzheimer disease. In all patients diffuse hypoperfusion was found evidencing a great diagnostic value of SPECT. A special significance has the study of regional cerebral blood flow in the differential diagnosis of Alzheimer disease, frontal lobe dementia and pseudodementia in major depression.
Subject(s)
Alzheimer Disease/diagnostic imaging , Basal Ganglia/blood supply , Basal Ganglia/diagnostic imaging , Parietal Lobe/blood supply , Parietal Lobe/diagnostic imaging , Tomography, Emission-Computed, Single-Photon , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Severity of Illness IndexABSTRACT
Two cases of posttraumatic apallic syndrome were described in which despite initially severe symptoms full recovery was observed. In complex treatment lasting several months the great role plays the stimulation of various receptors by physiological stimuli. In the discussion to treat or not to treat intensively the severe posttraumatic apallic syndrome our opinion is positively yes.
Subject(s)
Brain Injuries/drug therapy , Neuroprotective Agents/therapeutic use , Adult , Brain Injuries/complications , Brain Injuries/pathology , Coma/etiology , Humans , Male , Remission Induction , SyndromeABSTRACT
The incidence of cerebrovascular disease was established in the Poznan district in Poland for 1985. Mortality from cerebrovascular disease during this year was compared with mortality during 1977. The autopsy material from the years 1925 to 1985 was analyzed to differentiate ischemic from hemorrhagic stroke. The incidence of stroke was 198.3 per 100,000 inhabitants greater than 20 years of age. Mortality from cerebrovascular disease decreased significantly in both males and females from 1977 to 1985. Analysis of the pattern of cerebrovascular disease in the autopsy material from 1925 to 1965 demonstrated an overwhelming percentage of hemorrhagic stroke. In the years that followed, an inversion was noticed in the ratio of ischemic to hemorrhagic stroke. It should be assumed that the growing efficacy of antihypertensive therapy largely explains the decreasing incidence of stroke-induced mortality.
Subject(s)
Cerebrovascular Disorders/epidemiology , Adult , Age Factors , Aged , Cerebral Hemorrhage/complications , Cerebrovascular Disorders/complications , Cerebrovascular Disorders/mortality , Female , Humans , Incidence , Male , Middle Aged , Poland , Sex FactorsABSTRACT
The mortality from stroke in the years 1977 and 1985 was compared in the Province of Poznan. The mortality from strokes decreased in that time period considerably in the population of males and females. The differences were significant from the age group 40-49 years. Reduced mortality from stroke in the Province of Poznan contrasted with a reverse trend in the mortality from ischaemic heart disease, which has been increasing continuously. It may be supposed that increasing effectiveness in the treatment of arterial hypertension may explain, in part at least, reduction of the mortality index from strokes. One cannot exclude, however, taht partial elimination of other risk factor due to changed way of life, changed dietary habits, may play also a considerable role in the positive trends in the epidemiology of strokes.
Subject(s)
Cerebrovascular Disorders/mortality , Adult , Age Factors , Aged , Cerebrovascular Disorders/epidemiology , Female , Humans , Male , Middle Aged , Poland/epidemiology , Sex Factors , Space-Time ClusteringABSTRACT
A trial was made of finding a correlation between the incidence and prevalence of multiple sclerosis and large bowel carcinoma in several microregions (communities and areas of the former counties). The following conclusions have been reached. No correlation was found between the incidence of multiple sclerosis and large bowel carcinoma in these studied areas. A positive correlation was demonstrated between the prevalence of multiple sclerosis and large bowel carcinoma in the areas corresponding to former counties but not in communities. Since the latter index is of much lower importance for the estimation of the frequency of malignant neoplasms there is no reason to assume the existence of one or several common aetiologic factors of multiple sclerosis and large bowel carcinoma determining local differences in the frequency of these diseases.
Subject(s)
Colonic Neoplasms/epidemiology , Multiple Sclerosis/epidemiology , Adolescent , Adult , Aged , Child , Colonic Neoplasms/etiology , Humans , Middle Aged , Multiple Sclerosis/etiology , Poland , Risk Factors , Space-Time ClusteringABSTRACT
The incidence of malignant neoplasma was determined in patients with multiple sclerosis in epidemiological studies in 717 patients. No significant difference was found from the general population aged over 15 years. This seems to suggest that immunosuppression resulting from corticotherapy has no effect increasing the risk of malignant neoplasm development in multiple sclerosis.
