[Pharmacokinetic findings following the oral application of granulated Mebacid in cattle, calves and sheep]. / Pharmakokinetische Untersuchungsergebnisse nach oraler Applikation von Mebacidgranulat beim Rind, Kalb und schaf.

The pharmacokinetic properties of sulphamerazine, following oral application of granulated Mebacid to cattle, calf, and sheep, were compared with results obtained from the use of Mebacid tablets. Elimination half-life was higher in cattle, calf, and sheep, following oral application of Mebacid tablets. Different pharmacokinetic properties of sulphamerazine were found to exist between the two modes of preparation. Sulphonamide was eliminated more rapidly by cattle, calf, and sheep, when granulated Mebacid was used. When granulate is used, higher sulphamerazine doses have to be applied to calf and sheep to obtain the sulphonamide levels required for effective therapy. No intolerance was recorded from the above species, following oral application of granulated Mebacid.

[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 2. Elimination of Mebacid 200 and Mebacid tablets following oral, subcutaneous and intramuscular administration]. / Pharmakokinetische Modelluntersuchungen an Sulfamerazin bei Haussäugetieren. 2. Mitteilung: Die Elimination von Mebacid 200 und Mebacid-Tabletten nach oraler, subkutaner und intramuskulärer Applikation.

The mathematical foundations underlying pharmacokinetic testing and acceptance of medicaments for domestic mammals are expounded and discussed, with reference being made to examples of intramuscular, subcutaneous, and oral application of Mebacid 200 and Mebacid tablets. Elimination of sulphamerazine may be mathematically described by means of the following bi-exponential function: c = B x e-k2 x t -- A x e-k1 x t The concepts of the mono-compartmental model "Extravasal Application" can be claimed as being of basic validity. Blood levels established after intramuscular and subcutaneous application of sulphamerazine-sodium (Mebacid 200) were lower than those recorded after oral application of Mebacid tablets. The half-lives of elimination, following oral application to big animals of Mebacid tablets, were longer than those following intravenous application of comparable injection solution.

[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 1. Elimination of Mebacid 200 following intravenous administration to large animals]. / Pharmakokinetische Modelluntersuchungen an Sulfamerazin bei Haussäugetieren. 1. Mitteilung: Die Elimination von Mebacid 200 nach intravenöser Applikation beim Grosstier.

Pharmacokinetic data of sulphamerazine were recorded from eight heads each of calf, adult cattle, horse, and sheep, following intravenous application of Mebacid 200, and mathematical implications were discussed. Exponential excretion was recorded from all species, according to the following equation: c = B x e-k2 x t The most favourable pharmacokinetic parameters were recorded from calf.