ABSTRACT
The adsorption of bovine serum albumin from flowing solutions onto germanium and three polyetherurethanes varying in soft segment content was studied by a Fourier transform infrared/attenuated total reflectance technique. Spectral differences observed in the amide I, II, and III regions upon adsorption to all four surfaces were consistent with a loss of helix and gain of beta-structure. There appeared to be a slight difference between BSA adsorbed to germanium and the PEUs, but no distinction could be made between BSA adsorbed to the different PEUs.
Subject(s)
Biopolymers , Macromolecular Substances , Serum Albumin, Bovine , Adsorption , Spectrophotometry, InfraredSubject(s)
Protein Conformation , Proteins , Fourier Analysis , Serum Albumin, Bovine , Spectrophotometry, InfraredABSTRACT
The nature of a biomaterial surface governs the processes involved in biological response. Surface properties such as surface chemistry, surface energy, and morphology may be measured in order to understand the surface region of a biomaterial. In this article, we describe the surface characteristics of a few common biomaterials, review the techniques used to measure surface properties, and discuss the application of surface information in developing novel and improved biomaterials.
