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1.
Age Ageing ; 40(5): 534-7, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21642641
2.
J Psychopharmacol ; 20(6): 732-55, 2006 Nov.
Article in English | MEDLINE | ID: mdl-17060346

ABSTRACT

The British Association for Psychopharmacology (BAP) coordinated a meeting of experts to review the evidence on the drug treatment for dementia. The level of evidence (types) was rated using a standard system: Types 1a and 1b (evidence from meta-analysis of randomised controlled trials or at least one controlled trial respectively); types 2a and 2b (one well-designed study or one other type of quasi experimental study respectively); type 3 (non-experimental descriptive studies); and type 4 (expert opinion). There is type 1a evidence for cholinesterase inhibitors (donepezil, rivastigmine and galantamine) for mild to moderate Alzheimer's disease; memantine for moderate to severe Alzheimer's disease; and for the use of bright light therapy and aromatherapy. There is type 1a evidence of no effect of anti inflammatory drugs or statins. There is conflicting evidence regarding oestrogens, with type 2a evidence of a protective effect of oestrogens but 1b evidence of a harmful effect. Type 1a evidence for any effect of B12 and folate will be forthcoming when current trials report. There is type 1b evidence for gingko biloba in producing a modest benefit of cognitive function; cholinesterase inhibitors for the treatment of people with Lewy body disease (particularly neuropsychiatric symptoms); cholinesterase inhibitors and memantine in treatment cognitive impairment associated with vascular dementia; and the effect of metal collating agents (although these should not be prescribed until more data on safety and efficacy are available). There is type 1b evidence to show that neither cholinesterase inhibitors nor vitamin E reduce the risk of developing Alzheimer's disease in people with mild cognitive impairment; and there is no evidence that there is any intervention that can prevent the onset of dementia. There is type 1b evidence for the beneficial effects of adding memantine to cholinesterase inhibitors, and type 2b evidence of positive switching outcomes from one cholinesterase inhibitor to another. There is type 2a evidence for a positive effect of reminiscence therapy, and type 2a evidence that cognitive training does not work. There is type 3 evidence to support the use of psychological interventions in dementia. There is type 2 evidence that a clinical diagnosis of dementia can be made accurately and that brain imaging increases that accuracy. Although the consensus statement dealt largely with medication, the role of dementia care in secondary services (geriatric medicine and old age psychiatry) and primary care, along with health economics, was discussed. There is ample evidence that there are effective treatments for people with dementia, and Alzheimer's disease in particular. Patients, their carers, and clinicians deserve to be optimistic in a field which often attracts therapeutic nihilism.


Subject(s)
Dementia/drug therapy , Dementia/economics , Aged , Alzheimer Disease/diagnosis , Alzheimer Disease/diagnostic imaging , Alzheimer Disease/drug therapy , Alzheimer Disease/therapy , Cholinesterase Inhibitors/therapeutic use , Combined Modality Therapy , Consensus Development Conferences as Topic , Dementia/diagnosis , Dementia/prevention & control , Dementia/psychology , Dementia/therapy , Dementia, Vascular/drug therapy , Dementia, Vascular/therapy , Drug Therapy, Combination , Evidence-Based Medicine , Excitatory Amino Acid Antagonists/therapeutic use , Humans , Lewy Body Disease/drug therapy , Lewy Body Disease/therapy , Memantine/therapeutic use , Meta-Analysis as Topic , Psychotherapy , Radiography , Randomized Controlled Trials as Topic , Research Design , Treatment Outcome
3.
Br J Psychiatry ; 187: 143-7, 2005 Aug.
Article in English | MEDLINE | ID: mdl-16055825

ABSTRACT

BACKGROUND: Although there is good evidence that interventions for carers of people with Alzheimer's disease can reduce stress, no systematic studies have investigated psychotherapeutic intervention for patients themselves. This may be important in the earlier stages of Alzheimer's disease, where insight is often preserved. AIMS: The aim was to assess, in a randomised controlled trial, whether psychotherapeutic intervention could benefit cognitive function, affective symptoms and global well-being. METHOD: Individuals were randomised to receive six sessions of psychodynamic interpersonal therapy or treatment as usual; cognitive function, activities of daily living, a global measure of change, and carer stress and coping were assessed prior to and after the intervention. RESULTS: No improvement was found on the majority of outcome measures. There was a suggestion that therapy had improved the carers' reactions to some of the symptoms. CONCLUSIONS: There is no evidence to support the widespread introduction of brief psychotherapeutic approaches for those with Alzheimer's disease. However, the technique was acceptable and helpful individually.


Subject(s)
Alzheimer Disease/therapy , Psychotherapy, Brief/methods , Activities of Daily Living , Adaptation, Psychological , Aged , Aged, 80 and over , Alzheimer Disease/psychology , Caregivers/psychology , Cognition , Communication , Female , Humans , Interpersonal Relations , Male , Middle Aged , Psychiatric Status Rating Scales , Stress, Psychological , Treatment Outcome
4.
Pain ; 47(2): 197-202, 1991 Nov.
Article in English | MEDLINE | ID: mdl-1762815

ABSTRACT

The validity of the 28-item version of the General Health Questionnaire (GHQ-28) was determined by comparison with the Clinical Interview Schedule (CIS) in 56 pain clinic patients. Despite some limitations, the GHQ can be used effectively and cheaply as the first stage of an assessment to identify potential "cases" of mental disorder which must then be verified using a second-stage clinical interview such as the CIS. This process can result in a considerable reduction in the proportion of patients requiring a psychiatric interview and, therefore, in reduced service costs. Factors associated with lower validity coefficients include female sex, age above 60 years and pain with a duration of less than 2 years.


Subject(s)
Mental Disorders/diagnosis , Pain/psychology , Surveys and Questionnaires , Adult , Aged , Female , Humans , Male , Mental Disorders/complications , Mental Disorders/epidemiology , Middle Aged , Predictive Value of Tests
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