[The combined radionuclide diagnosis of rectal cancer recurrences]. / Kompleksnaia radionuklidnaia diagnostika raka priamoi kishki.

Of 153 patients with confirmed rectal cancer CEA was recorded in 139 (90.8%); erroneous results were noted in 14 (9.2%) patients; in scintigraphy with 67Ga-citrate and 111In-bleomycin diagnoses coincided in 147 (96.1%) patients, and false-negative results were noted in 6 (3.9%) patients. During the investigation 16 patients who had undergone radical operation with any signs of recurrence and 36 patients with suspected tumor recurrence, scintigraphic false-positive results were observed in 12.5 and 30.6% patients, and a false-positive increase in the CEA titer was observed in 12.5 and 11.1%. Of 11 patients with false-positive scintigraphic results a rise of the CEA level was noted in 2 cases making it possible to rule out with a great degree of assurance the presence of a recurrent tumor. The results obtained suggest the appropriateness of the combination of these methods to improve the diagnosis of rectal cancer recurrences.

[Thermography with glucose loading in the examination of women at high risk of developing breast cancer]. / Termografiia s nagruzkoi gliukozoi v obsledoavnii zhenshchin s vysokim riskom razvitiia raka molochnoi zhelezy.

Thermography of the breast with pharmacological GTT was performed in 260 women; cancer was diagnosed in 150 of them, benign breast diseases in 110. A significant increase in temperature asymmetry after GTT was shown in breast cancer patients as compared to patients with benign diseases. Data on the sensitivity of the mammographic and thermographic methods to identify risk groups were presented.

[Radionuclide and thermographic diagnosis of regional metastases of cancer of the tongue and larynx]. / Radionuklidnaia i termograficheskaia diagnostika regionarnykh metastazov raka iazyka i gortani.

To study the potentialities of scintigraphy with 67Ga-citrate and thermography these investigations of the neck lymph nodes were performed in 120 patients with cancer of the tongue and larynx. All the patients were divided into 4 groups with relation to the clinical manifestations of the nodes. The sensitivity of both methods was 87.9 and 88.9%, their specificity--68.2 and 53.3%, respectively. Radionuclide investigation in 4.6% and thermography in 7.1% made it possible to correct clinical errors. The above methods play an important role in combined diagnosis of regional metastases.

[Radionuclide diagnosis of vasculogenic impotence]. / Radionuklidnaia diagnostika vaskulogennoi impotentsii.

Pathogenesis of vasculogenic impotence is most adequately revealed by modern methods of the investigation of the hemodynamic mechanisms of erection with the enhancement of arterial perfusion of corpora cavernosa by artificial sexual stimulation. Radionuclide diagnostic methods effectively differ from the methods of radiocontrast phalloangiography by the simplicity of investigation and the absence of traumatism for a patient. The authors have proposed a mathematical model of a process of filling in the functioning volume of the penile vascular bed with a radiopharmaceutical preparation against the background of erection induced by intracavernous administration of papaverine hydrochloride solution. Parameters of the model determine the ratio of blood flow volumetric rates in the penis at rest and when erect.

[Thermo- and scintigraphy with 67Ga citrate in the diagnosis of oro- and parapharyngeal tumors]. / Termo- i stsintigrafiia s 67Ga-tsitratom v diagnostike oro- i parafaringeal'nykh opukholei.

The authors analyzed the results of thermographic and scintigraphic (using 67Ga-citrate produced in the USSR) investigations in 41 patients: 10 with tumors of the oral cavity, 12 with oropharyngeal tumors, and 19 with parapharyngeal tumors. Of the latter 10 had morphologically verified benign tumors, 5--mixed type tumors, and 4--malignant tumors (sarcoma in 2 patients, a thyroid cancer metastasis to the parapharyngeal lymph nodes in 1, malignant chemodectoma in 1). Thermography and scintigraphy positive results (the absence of hyperthermia and RP hyperfixation in a tumor) were obtained in 7 of 10 patients with benign parapharyngeal tumors. Thermography false-positive results were obtained in 3 patients, however 67Ga-citrate accumulation was undetectable in these patients' tumors making the diagnosis more accurate. Thermography and scintigraphy results were positive in all 22 patients with malignant oropharyngeal (the oral cavity and oropharynx) tumors. Thermography and scintigraphy positive results were also noted in all 5 patients with parapharyngeal mixed tumors which could be associated with raised tumor tissue biological activity. The data obtained suggested a possibility of the use of thermography and scintigraphy in the diagnosis of oro-and parapharyngeal tumors.

[Scintigraphy with 67Ga-citrate and 111In-bleomycin in cancer of the rectum]. / Stcintigrafiia s 67Ga-tsitratom i 111In-bleomitsinom pri rake priamoi kishki.

Scintigraphy with 67Ga-citrate and 111In-bleomycin was performed in 26 patients with primary rectal cancer, 176 patients with suspected recurrent tumors, and in 34 patients without clinicoroentgenological signs of cancer recurrence. A focus of higher accumulation of these radionuclides in the rectal area was recorded in all 26 patients. Of 176 patients with symptoms of recurrence tumors were detected by means of ultrasonic and computed tomography of the small pelvis in 158 patients. False-positive results were marked in 18 (10.2%) patients with chronic inflammatory processes at the site of the resected rectum, in anastomosis, and prostatic adenoma. In the control group of 34 patients false-positive results were marked in 8.8%. Positive scintigraphy used in combined diagnosis of rectal cancer recurrences holds promise.

[Thermography and radionuclide scintigraphy in reconstructive plastic operations following radical mastectomy]. / Termografiia i radionuklidnaia stsintigrafiia pri rekonstruktivno-plasticheskikh operatsiiakh posle radikal'noi mastéktomii.

Thermography is quite an informative and reliable method of examination of patients after reconstructive-plastic breast operations. It makes it possible to assess, with a sufficient degree of assurance, the blood circulation in a skin-muscular graft of the broadest muscle of the back, to diagnose capsule constrictive fibrosis, to detect foci of hyperthermia at the edge of endoprosthesis in the presence of bulky formations hidden by an implant, and can be recommended for the screening of such patients. In some cases scintigraphy makes it possible to differentiate between tumor and non-tumor origin of foci of lesions detected in endoprosthesis.

[Thermography and computed tomography in the diagnosis of cancer recurrence after rectal extirpation]. / Termografiia i komp'iuternaia tomografiia v diagnostike retsidiva raka posle ékstirpatsii priamoi kishki.

The results of thermography and computed tomography of 168 patients following rectum extirpation for cancer were analysed. Of them 116 had symptoms of cancer recurrence and 52 with a poor prognosis were without signs of recurrence. In the 1st group thermography made it possible to record recurrences in 106 (91.4%) patients whereas computed tomography in 102 (87.9%). In thermography overdiagnosis was observed in 8 (6.9%) cases as a result of chronic inflammatory processes in the small pelvis. In computed tomography erroneous results were obtained in 4 (3.5%) cases. In the absence of recurrence symptoms the use of both methods made it possible to detect tumor recurrences in 11 (21.2%) patients at a preclinical stage. In the authors' opinion, thermography provides an opportunity to assume the presence of a recurring tumor and to make up a high risk group of patients who are in need of an active follow-up and thorough examination using other methods.

[Thermography in the diagnosis of retinoblastoma in children]. / Termografiia v diagnostike retinoblastomy u detei.

The authors presented the results of thermographic examination of children with suspected retinoblastoma (30 primary examined patients and 30 patients examined to assess therapeutic efficacy). The results of the examination showed the relationship of the intensity and extent of the hyperthermia zone with tumor stage. The usefulness of the thermographic method for efficacy assessment was shown.

[Scintigraphy with 111In-bleomycin in the diagnosis of recurrences of rectal cancer]. / Stsintigrafiia s 111In-bleomitsinom v diagnostike retsidivov raka priamoi kishki.

Altogether 76 patients were examined using scintigraphy with 111In-bleomycin. Clinicoroentgenological diagnosis of recurring rectal cancer was confirmed in 62 of them. Fourteen patients were without signs of recurrence. A focus of RP hyperfixation in the small pelvis was revealed on scintigrams in 52 (84%) of 62 patients. In 4 cases the results of examination were considered doubtful, and in 6 cases the results were false positive. Of 14 recurrence-free patients 4 had recurring tumors at early stages prior to clinical manifestations. The authors pointed to the prospects of the employment of 111In-bleomycin for diagnosis of rectal cancer recurrences.

[Thermography in the diagnosis of recurrences of rectal cancer]. / Termografiia v diagnostike retsidivov raka priamoi kishki.

Thermography results of 126 patients were analysed for the diagnosis of recurrences of rectal cancer. Sixteen patients were examined after radical operations for rectal cancer without signs of recurrence to study the features of a thermal regimen in this area. The examination included thermoscopy, thermography and distant thermometry. The presence of the zone of hyperthermia in the perineum with the involvement of the sacral region and the coccygeal bone after extirpation of the rectum was shown to indicate cancer recurrence. The coincidence of thermography findings with those of computerized and ultrasound tomography was observed in 81.7% of the cases. As a result of a perineal fistula, chronic prostatitis, etc., false positive results of thermography were marked in 17 (18.3%) patients. False negative results were not observed. A rise of local temperature from +0.5 to 1 degrees C was considered suspicious of cancer recurrence. These patients were actively followed up and it allowed one to confirm cancer recurrence in them after 3-6 mos. The use of thermography as a screening test made it possible to detect cancer recurrence and to define a high risk group in need of an active follow up and more thorough clinical examination.

[Radionuclide-thermographic diagnosis of neck paragangliomas]. / Osobennosti radionuklidno-termograficheskoi diagnostiki paragangliom shei.

Nonchromaffin paragangliomas (chemodectomas) are rare tumors. Diagnosis of paraganglion tumors is difficult. The main diagnostic method is carotid angiography. Radionuclide thermographic studies were conducted in 16 neck paraganglioma patients for comprehensive diagnosis. Malignant tumors were found in 6 out of 16 patients. Paragangliomas of the carotid corpuscle were noted in 14 patients, those of the vagus nerve in 2 patients. In benign paraganglioma hyperthermia of the neck in the tumor region did not exceed 1.2 degrees C in 8 out of 10 patients. In all 6 patients with malignant paragangliomas, hyperthermia from 1.3 degrees and upwards was noted in the tumor region on the thermograms. On the scintigrams foci of increased RP accumulation were noted in 4 patients with malignant and in 2 patients with benign paragangliomas. The use of the radionuclide and thermographic methods makes it possible to extend the potentialities of differential diagnosis of benign and malignant neck paragangliomas.

[Radionuclide and thermographic diagnosis of head and neck neoplasms]. / Radionuklidnaia i termograficheskaia diagnostika novoobrazovanii golovy i shei.

Radionuclide and thermographic studies using 67Ga-citrate and 111In-bleomycin were performed in 129 patients with laryngeal cancer, chemodectoma of the neck, retinoblastoma, rhabdomyosarcoma of the orbital and facial soft tissues and cancer of the tongue. Elevated amounts of the radiopharmaceutical drug were found in patients with tumors. In thermographic studies higher thermogenic activity corresponding to the tumor was noted. Radionuclide thermographic studies extend diagnostic opportunities for head and neck tumors.

[Importance of thermography in the overall examination of oncological patients]. / Znachenie termografii v kompleksnom obsledovanii onkologicheskikh bol'nykh.

Possibilities of remote thermography for differential diganosis of malignant and bening tumours are described. It helps in more exact definition of tumours topography and distribution for better planning of their irradiation. Diagnostic accuracy at the combined thermographic and radioisotope investigations was proved on 153 women with mammary gland diseases and on 77 women with soft tissue damage. Some recommendations offered concern the improvement of thermovision apparatus.