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1.
Clin Investig (Lond) ; 4(12): 1065-1081, 2014 Dec 01.
Article in English | MEDLINE | ID: mdl-25574373

ABSTRACT

BACKGROUND: Diabetes and its complications are a major United States public health concern. METHODS: The Diabetes and Periodontal Therapy Trial (DPTT) evaluated whether non-surgical treatment of periodontal disease influenced diabetes management among persons with Type 2 diabetes and periodontitis. The aim of this study was to evaluate DPTT's many recruitment strategies in terms of enrollment success. RESULTS/CONCLUSION: Targeted recruitment strategies were more effective in identifying individuals who met periodontal and diabetes eligibility criteria. Individuals eligible for a baseline visit/enrollment were more often male, had a younger age at diabetes diagnosis, a longer diabetes duration, more often Hispanic and less often African-American. Tracking and evaluating recruitment sources during study enrollment optimized recruitment methods to enroll a diverse participant population based upon gender, race and ethnicity.

2.
Dent Mater ; 28(7): 792-800, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22578989

ABSTRACT

OBJECTIVE: Conventional diagnostic methods frequently detect only late stage enamel demineralization under composite resin restorations. The objective of this study is to examine the subsurface tooth-composite interface and to assess for the presence of secondary caries in pediatric patients using a novel Optical Coherence Tomography System with an intraoral probe. METHODS: A newly designed intraoral cross polarization swept source optical coherence tomography (CP-OCT) imaging system was used to examine the integrity of the enamel-composite interfaces in vivo. Twenty-two pediatric subjects were recruited with either recently placed or long standing composite restorations in their primary teeth. To better understand how bacterial biofilms cause demineralization at the interface, we also used the intraoral CP-OCT system to assess ex vivo bacterial biofilm growth on dental composites. RESULTS: As a positive control, cavitated secondary carious interfaces showed a 18.2dB increase (p<0.001), or over 1-2 orders of magnitude higher, scattering than interfaces associated with recently placed composite restorations. Several long standing composite restorations, which appeared clinically sound, had a marked increase in scattering than recently placed restorations. This suggests the ability of CP-OCT to assess interfacial degradation such as early secondary caries prior to cavitation. CP-OCT was also able to image ex vivo biofilms on dental composites and assess their thickness. SIGNIFICANCE: This paper shows that CP-OCT imaging using a beam splitter based design can examine the subsurface interface of dental composites in human subjects. Furthermore, the probe dimensions and acquisition speed of the CP-OCT system allowed for analysis of caries development in children.


Subject(s)
Biofilms/growth & development , Composite Resins/chemistry , Dental Caries/diagnosis , Dental Enamel/microbiology , Tomography, Optical Coherence/instrumentation , Child , Child, Preschool , Dental Caries/etiology , Dental Enamel/chemistry , Female , Humans , Male , Tomography, Optical Coherence/methods
3.
J Clin Microbiol ; 49(7): 2691-3, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21543566

ABSTRACT

The reliability of the BacT/Alert 3D unit for automated detection of nontuberculous mycobacteria (NTM) that grow optimally at 30 °C was assessed. This system reliably maintained a temperature of 30 °C and detected 50% of the clinical NTM strains (5 Mycobacterium marinum and 3 Mycobacterium gordonae strains) faster than 37 °C culture.


Subject(s)
Automation/methods , Bacteriological Techniques/methods , Mycobacterium Infections/diagnosis , Mycobacterium marinum/classification , Mycobacterium marinum/isolation & purification , Nontuberculous Mycobacteria/classification , Nontuberculous Mycobacteria/isolation & purification , Humans , Mycobacterium marinum/growth & development , Nontuberculous Mycobacteria/growth & development , Sensitivity and Specificity , Temperature
4.
J Orofac Pain ; 16(4): 296-304, 2002.
Article in English | MEDLINE | ID: mdl-12455430

ABSTRACT

AIMS: The operational definitions for the Craniomandibular Index (CMI) were redesigned to conform precisely to those of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), resulting in a single examination protocol, the Temporomandibular Index (TMI). The objectives were to evaluate interexaminer reliability of the TMI as well as its criteria and construct validity for measurement of TMD severity. METHODS: Interexaminer reliability of the TMI was assessed on 12 subjects. Criterion validity of the TMI was evaluated relative to the CMI, the latter having established validity. Construct validity of the TMI was evaluated for its capacity to differentiate TMD patients (n = 79) from normal subjects (n = 20) and to detect changes in severity over time. RESULTS: The examiner's average TMI scores were 0.27 +/- 0.19 (SD) and 0.26 +/- 0.20. Agreement was excellent, with an intraclass correlation coefficient (ICC) of 0.93. The scores for the TMI and the CMI correlated highly, with an ICC of 0.97. Statistical contrasts between the symptomatic groups and the normal subjects were highly significant (P < .001). In 20 TMD patients who underwent treatment for their disorder, their mean change of 0.12 from their pretreatment TMI scores was highly significant (P < .001). CONCLUSION: This study has provided statistical evidence for the clinical reliability and validity of the TMI, which indicates that the RDC examination protocol is appropriate for determining TMD severity by the TMI algorithm, and diagnosis of TMD subtypes by the RDC algorithm.


Subject(s)
Outcome Assessment, Health Care/methods , Psychometrics , Severity of Illness Index , Temporomandibular Joint Disorders/classification , Temporomandibular Joint Disorders/diagnosis , Adolescent , Adult , Algorithms , Arthralgia/diagnosis , Facial Pain/diagnosis , Female , Humans , Male , Masticatory Muscles/physiopathology , Observer Variation , Pain Measurement , Range of Motion, Articular , Reproducibility of Results
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