ABSTRACT
Post-translational modifications of proteins can regulate the balance between survival and cell death signals. It is increasingly recognized that nitric oxide (NO) and reactive oxygen species (ROS)-induced post-translational modifications could play a role in cell death. This review provides an introduction of current knowledge of NO proteins modifications promoting or inhibiting cell death with special attention in cancer cells.
Subject(s)
Apoptosis , Neoplasms/pathology , Nitric Oxide/physiology , Protein Processing, Post-Translational/physiology , Humans , Neoplasms/metabolism , Nitric Oxide/metabolism , Signal TransductionABSTRACT
This report summarizes the present state of our knowledge pertaining to the NO-induced resistance or sensitization of tumor cell death. The effects of NO and its synergy with members of the TNF family, with cytotoxic drugs, and with ionizing radiations have been investigated. The dual effect of NO-induced resistance or sensitization and the underlying molecular mechanisms are discussed.
