Use of polar decomposition of Mueller matrices for optimizing the phase response of a liquid-crystal-on-silicon display.

We provide experimental measurement of the Mueller matrices corresponding to an on-state liquid-crystal-on-silicon display as a function of the addressed voltage. The polar decomposition of the Mueller matrices determines the polarization properties of the device in terms of a diattenuation, a retardance and a depolarization effect. Although the diattenuation effect is shown to be negligible for the display, the behavior of the degree of polarization as a function of the input polarization state shows a maximum coupling of linearly polarized light into unpolarized light of about 10%. Concerning the retardation effect, we find that the display behaves as a retarder with a fast-axis orientation and a retardance angle that are voltage-dependent. The above decomposition provides a convenient framework to optimize the optical response of the display for achieving a phase-mostly modulation regime. To this end, the display is sandwiched between a polarization state generator and a polarization state analyzer. Laboratory results for a commercial panel show a phase modulation depth of 360 masculine at 633 nm with a residual intensity variation lower than 6 %.

Cyclic 3'-5' guanosine monophosphate-dependent activity in Leishmania amazonensis

Although there are some data concerning the nitric oxide and the cyclic 3'-5'guanosine monophosphate (cGMP) signaling pathway in trypanosomatids, there is no report about the cGMP-dependent enzymatic activity identification. In this sense, a cGMP dependent activity was detected on soluble fraction from Leishmania amazonensis promastigotes with a high metacyclic level. This information is valuable in order to explore the metabolic pathway of G kinase protein in this parasite

Effect of amidine derivatives on Leishmania amazonensis axenic amastigotes. Preliminary studies of structure-activity relationships

In a previous work, searching for new drugs with high efficiency and low toxicity, the in vitro antileishmanial activity of a series of seven amidine derivatives against Leishmania amazonensis promastigotes was reported. In order to compare the potential difference in the susceptibility between the two developmental stages of the parasite to these compounds, an analysis of the effects of these amidine derivatives on promastigotes and axenically grown amastigotes of L. amazonensis was carried out. Among the N,N'-diphenyl-4-R-benzamidine (where R = H, Cl, Br, CN, NO2, CH3 and OCH3) derivatives studied, the most active compounds in both developmental stages were those with -Br, -Cl, -NO2, and -OCH3 substituents, the nonsubstituted ones being the least active. However, the susceptibility to the drugs varied in these forms, being higher in promastigotes. The electronic theoretical parameters calculated by molecular modelling using the semi-empirical AM1 method showed good correlation with substituent constant (sigma para, sigma 1 and F). The chemical structure and biological activity relationships were investigated in all compounds, although a small but significant correlation was observed. The obtained results suggest that other factors than the electronic parameters have an influence on the biological response.