[Depression, anxiety and stress in college students before and during the first three months of COVID-19 lockdown]. / Depresión, ansiedad y estrés en estudiantes universitarios antes y durante los primeros tres meses de cuarentena por COVID-19.

Introduction: Different psychological symptoms of distress as well as drinking motives have been associated with alcohol use in college students. The COVID-19 lockdown [aislamiento social, preventivo y obligatorio (ASPO)] reduced movement to a minimum, impacting college students' mental health and generating changes in several behaviours, including alcohol use.Objectives: To examine the association between symptoms of anxiety, depression and stress, drinking motives and alcohol use in two groups of Argentinian college students, before and during the first three months of lockdown. In addition, it was examined whether drinking motives mediate the relationship between psychological distress and alcohol use.Methods: Two samples of college students, one before the lockdown (n=125; mean age, 23.87 ± 3.27 years; 73.6% women) and another during the lockdown (n=174; 24.32 ± 3.64 years; 78.2% women) completed an online survey.Results: Alcohol use, as well as social and enhancement motives, decreased in college students during lockdown. The associations between psychological distress and drinking motives with alcohol use were more consistent in the group during lockdown compared with the group after lockdown. At a multivariate level, coping motives explained an increased frequency of alcohol consumption in college students during lockdown.Conclusions: It is necessary to pay special attention to the mental health of college students who have experienced changes in their routines as a result of the restrictions implemented during the pandemic.

Impulsivity, alcohol use and risky sexual behaviors in college students / [Impulsividad, consumo de alcohol y conductas sexuales riesgosas en estudiantes universitarios]

Introduction: Alcohol use in college students and related consequences, such as risky sexual behaviors, are a public health issue. Impulsivity is relevant to study alcohol use behaviors. This study aimed to analyze the effect of trait impulsivity (UPPS-P model), age of onset of alcohol use (AOA) and of sexual intercourse (AOS), alcohol use and risky sexual behavior under the influence of alcohol (RSBA). Materials and methods: 196 students (71.9% women, M age= 22.46; SD = 2.74) from the National University of Córdoba completed an online survey. We conducted bivariate and multivariate analyzes to examine the relationship between risk factors and RSBA. Results: AOA and AOS had a negative association with RSBA, while alcohol quantity and trait impulsivity was positively associated with RSBA. At the multivariate level, AOA and alcohol quantity directly influenced RSBA. The AOS and sensation seeking had an indirect effect via alcohol quantity. Discussion: This results provide evidence on the role of early initiation in alcohol use, impulsivity and alcohol use on RSBA in college students. This information can be useful for the development of preventive programs specifically designed for this population.

Introducción: El consumo de alcohol en estudiantes universitarios y sus consecuencias negativas, como las conductas sexuales de riesgo, representan una problemática de salud pública. La impulsividad es relevante para estudiar las conductas de consumo de alcohol. Este estudio tuvo como objetivo analizar el efecto de la impulsividad rasgo (modelo UPPS-P), la edad de inicio en el consumo de alcohol (EIA) y de las relaciones sexuales (EIS) y el consumo de alcohol sobre las conductas sexuales de riesgo bajo los efectos del alcohol (CSRA). Materiales y métodos: 196 estudiantes (71.9% mujeres, edad M = 22.46; DE = 2.74) de la Universidad Nacional de Córdoba completaron una encuesta online. Mediante análisis bivariados y multivariados se examinó la relación entre factores de riesgo y las CSRA. Resultados: La EIA y EIS tuvieron una asociación negativa con las CSRA, mientras que la cantidad de alcohol y la impulsividad rasgo se asociaron positivamente con las CSRA. A nivel multivariado, la EIA y la cantidad de alcohol consumida influyeron directamente sobre las CSRA. La EIS y la búsqueda de sensaciones tuvieron un efecto indirecto a través de la cantidad de alcohol consumida. Discusión: Los resultados aportan evidencia sobre el rol que tienen el inicio temprano en el consumo de alcohol, la impulsividad y el consumo de alcohol en las CSRA en estudiantes universitarios. Esta información puede resultar de gran utilidad para el desarrollo de programas preventivos destinados específicamente a esta población.

Anticonvulsant hypersensitivity syndrome: clinic case and literature review.

INTRODUCTION: The anticonvulsant hypersensitivity syndrome is a rare adverse reaction in which the skin, lymph nodes and internal organs are affected. It is usually caused by classic anticonvulsants such as phenytoin, carbamazepine or phenobarbital. CASE REPORT: Here we present the case of a 25-year-old woman from Córdoba, Argentina, who suffered a severe reaction to oxcarbazepine with a rash, lymphadenopathy, hepatitis and an unusual analytic. Clinical abnormalities were reversed after oxcarbazepine was terminated and treatment with diphenhydramine and dexamethasone was initiated. DISCUSSION: DRESS syndrome is a hypersensitivity reaction that takes weeks to manifest, and is characterized by rash, leukocytosis with eosinophilia, adenopathies, liver involvement, and reactivation of the herpes virus 6, being more frequent in carbamazepine or phenytoin, and in rare cases to oxcarbazepine. CONCLUSIONS: In general, this strong medicine is not taken into account as a cause of hypersensitivity, reports suggest that it could be related to cases similar to this one, and studies that are more targeted are required, due to the morbidity and mortality of the syndrome.

Introducción: El síndrome de hipersensibilidad a los anticonvulsivantes es una reacción adversa rara en la que se ven afectados la piel, los ganglios linfáticos y los órganos internos. Generalmente es causada por anticonvulsivos clásicos como fenitoína, carbamazepina o fenobarbital. Caso clínico: Aquí presentamos el caso de una mujer de 25 años de Córdoba, Argentina, que sufrió una reacción severa a la oxcarbazepina con una erupción cutánea, linfadenopatías, hepatitis y un analítico inusual. Las anormalidades clínicas se revirtieron después de que se terminara la oxcarbazepina y se inició el tratamiento con difenhidramina y dexametasona. Discusión: El síndrome DRESS es una reacción de hipersensibilidad que tarda semanas en manifestarse, y se caracteriza por exantema, leucocitosis con eosinofilia, adenopatías, afectación hepática, y reactivación del virus herpes 6, siendo más frecuente ante carbamazepina o fenitoína, y en raros casos a oxcarbazepina. Conclusiones: Por lo general, este medicamento fuerte no se toma en cuenta como causa de hipersensibilidad, los informes sugieren que podría estar relacionado con casos similares a este, y se requieren estudios que sean más dirigidos, debido a la morbimortalidad del síndrome.