ABSTRACT
The synthesis and antitumor activity of a novel didemnin B analogue containing a psi[CH2NH] amide bond surrogate between N-Me-D-Leu7 and Pro8 are reported. The analogue shows activity (GI50 = 4 nM) comparable to that of didemnin B (GI50 = 13 nM) in the NCI-60 tumor cell screen. This result, along with new data from previously reported synthetic didemnin analogues, is discussed within the context of the side-chain SAR for didemnins.
Subject(s)
Depsipeptides , Peptides, Cyclic/chemical synthesis , Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Combinatorial Chemistry Techniques , Drug Screening Assays, Antitumor , Humans , Molecular Mimicry , Peptides, Cyclic/chemistry , Peptides, Cyclic/pharmacology , Structure-Activity Relationship , Tumor Cells, Cultured/drug effectsABSTRACT
Linear Solvation Energy Relationships (LSERs) are used to explain the congeneric behavior observed when using Micellar Electrokinetic Chromatography (MEKC) to estimate the octanol-water partition coefficient scale of solute hydrophobicity. Such studies provide useful insights about the nature of solute interactions that are responsible for the sources of congeneric relationships between MEKC retention and log Po/w. It was determined that solute dipolarity/polarizability and hydrogen-bonding character play the most important roles in the congeneric behavior observed for many surfactant systems. The individual dipolarity/polarizability and hydrogen-bonding contributions to the free energy of transfer were also investigated.
Subject(s)
Chromatography, Micellar Electrokinetic Capillary/methods , Octanols/chemistry , Water/chemistry , Hydrogen BondingABSTRACT
Some authors have hypothesized a relationship between rear-impact motor vehicle collisions and subsequent symptoms of neck pain and temporomandibular disorders, or TMD, despite no facial impact. This article examines the TMD aspect in terms of the physiological basis and cultural factors influencing the reporting of such symptoms.
Subject(s)
Temporomandibular Joint Dysfunction Syndrome/etiology , Whiplash Injuries/complications , Accidents, Traffic , Cross-Cultural Comparison , Humans , Temporomandibular Joint/injuries , Temporomandibular Joint Dysfunction Syndrome/diagnosis , Temporomandibular Joint Dysfunction Syndrome/epidemiology , Temporomandibular Joint Dysfunction Syndrome/psychology , Whiplash Injuries/epidemiology , Whiplash Injuries/physiopathologyABSTRACT
This article reviews the role of the maxillary frenum in diastema formation and provides guidance on procedures to remove it in both dentate and edentate patients.
Subject(s)
Diastema/therapy , Labial Frenum , Diastema/etiology , Humans , Labial Frenum/surgeryABSTRACT
This survey was performed to determine whether community pharmacists respond appropriately when they encounter an oral lesion of extended duration--which is a sign of potential oral carcinoma. An interviewer visited 101 community pharmacies in the Minneapolis-St. Paul area, Rochester, and St. Cloud, Minn. The interviewer told the pharmacist: "My grandmother has had an ulcer on the floor of her month for two or three months." Two-thirds of the pharmacists recommended purchasing a product available in the pharmacy; only one-third recommended an appointment with a physician or dentist. This finding appears to indicate a substantial deficit in pharmacists' clinical knowledge of oral conditions. To correct this problem, pharmacists' education should address oral conditions and place increased emphasis on clinical presentation.
Subject(s)
Carcinoma , Mouth Neoplasms , Pharmacists , Pharmacies , Referral and Consultation , Time FactorsABSTRACT
This article reviews an eclectic collection of problems. There is no particular reason why any one of them was chosen other than that they are more likely to occur in the course of practice than some other complications such as an oro-antral fistula or trauma to the lingual nerve or tissue emphysema. These latter and some other predicaments were discussed in the course of the talks given by the author at the 28th Australian Dental Congress in March 1995. The problems discussed in this paper are: 1. Dentoalveolar abscess anaesthesia. 2. Inability to obtain effective anaesthesia. The complications: 1. Post-extraction haemorrhage. 2. Syncope. 3. Postoperative infection.
Subject(s)
Mouth/surgery , Postoperative Complications , Ambulatory Surgical Procedures , Anesthesia, Dental , Anesthesia, Local , Humans , Oral Hemorrhage/etiology , Periapical Abscess/surgery , Surgical Wound Infection/etiology , Syncope/etiology , Tooth Extraction/adverse effectsABSTRACT
This article describes the clinical testing of a new system for the intraosseous delivery of local anesthesia. The author concluded that the system delivered local anesthetic very effectively (in some situations more effectively than the traditional delivery method), thus offering a great potential advantage to both dentists and patients.
Subject(s)
Anesthesia, Dental/instrumentation , Anesthesia, Local/instrumentation , Lidocaine/administration & dosage , Anesthesia, Dental/methods , Anesthesia, Local/methods , Humans , Injections/methods , Mandible , Needles , Syringes , Time Factors , Tooth ExtractionABSTRACT
Medicine-bashing is in vogue; but is there substance behind the empty 'sound bites'; cheap shots and screaming headlines, or is it all just political rhetoric? This essay examines some of the issues and tries to place the costs and technologicalization of medicine and dentistry in a perspective of historical development. The truth is that there is much truth in the criticisms. Howsoever, this is not a jeremiad essay--solutions to our problems exist and they are not Utopian--the real question is whether we are able to learn and put into our practice our lessons.
Subject(s)
Technology, High-Cost/statistics & numerical data , Cost-Benefit Analysis , Europe , History, 15th Century , History, 16th Century , History, 19th Century , History, 20th Century , Humans , Medical Laboratory Science/history , Technology, Dental/history , Technology, High-Cost/trends , United StatesABSTRACT
The decision to extract a third molar should be made only after considering all possible outcomes of this treatment. If the practitioner decides to remove a third molar, then a meticulous course of surgery and postoperative care should be performed.
