ABSTRACT
Malignant melanoma with osteocartilaginous differentiation is extremely rare. We report a case of periungual osteocartilaginous melanoma (OCM) on the right hallux. A 59-year-old man presented with a rapidly growing mass with drainage on his right great toe after treatment of ingrown toenail and infection 3 months earlier. Physical examination showed a 2.0×1.5×1.0-cm, malodorous, erythematous, dusky, granuloma-like mass along the fibular border of the right hallux. Pathologic evaluation of the excisional biopsy revealed diffuse epithelioid and chondroblastoma-like melanocytes with atypia and pleomorphism in the dermis with strong SOX10 immunostaining. The lesion was diagnosed as osteocartilaginous melanoma. The patient was referred to a surgical oncologist for further treatment. Osteocartilaginous melanoma is a rare variant of malignant melanoma that needs to be differentiated from chondroblastoma and other lesions. Immunostains for SOX10, H3K36M, and SATB2 are helpful for the differential diagnosis.
Subject(s)
Bone Neoplasms , Chondroblastoma , Hallux , Melanoma , Skin Neoplasms , Male , Humans , Middle Aged , Hallux/pathology , Skin Neoplasms/pathology , Melanoma/diagnosis , Melanoma, Cutaneous MalignantABSTRACT
BACKGROUND: Schwannoma is most often grown on the trunk, upper and lower extremities, and head and neck, but rarely on the foot. This study aimed to reveal clinical presentations, histopathology and treatment options for schwannoma of the foot. MATERIALS AND METHODS: Seven schwannomas out of 174 soft-tissue tumors on the foot and ankle were retrieved from our Institute in a 3-year period, and 42 schwannomas on the foot and ankle in the literature in a 30-year period were reviewed. RESULTS: The incidence of schwannoma of foot was found to be 4.0%. The patient age ranged from 8 to 84 years, with a mean of 47.4 years. More than 80% of tumors were located on the ankle, heel and plantar aspect. Overall, 77.6% of patients complained about a painful mass. Magnetic resonance imaging revealed a well-circumscribed, round or ovoid mass with iso-intensity signal compared with surrounding neuromuscular tissues on T1-weighted images and hyper-intensity signal on T2. Forty-eight out of 49 patients were treated with surgical excision or enucleation without recurrence in follow-up from 2 months to 4 years. Histologically, schwannoma was composed of hypercellular Antoni A zone with palisaded spindle cells with strong immunostaining for S-100 and hypocellular Antoni B zone with vascularization in myxoid stroma. CONCLUSION: Schwannoma of the foot and ankle is a rare, painful, indurated tumor. Magnetic resonance imaging reveals the location, size, texture and relationships with surrounding neuromuscular structures. Surgical excision is the primary treatment option with excellent outcome.
Subject(s)
Ankle/pathology , Foot/pathology , Neurilemmoma/diagnosis , Adolescent , Adult , Aged , Biopsy , Child , Diagnosis, Differential , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Staging , Tumor Burden , Young AdultABSTRACT
En este trabajo se analizan los problemas sociales culturales y económicos de 120 prostitutas menores de 21 años controladas sanitariamente por el Servicio Antivenérico dependiente de la División de Venereología del Ministerio de Sanidad y Asistencia Social, ubicado en el Ambulatorio Tipo II de la Sabanita en Ciudad Bolivar. Se indagó acerca de los ingresos, estructura familiar y actitudes hacia la prostitución; se abarco el aspecto médico-sanitario lo relativo a uso y evaluación de métodos anticonceptivos, se obtuvo también información sobre las nociones, creencias y forma de prevenir las enfermedades venéreas. Para tales efectos se tomó un grupo etario comprendido entre 16-21 años. La recolección de la información se prolongó por 5 meses entrevistando directamente a las prostitutas en el consultorio de Venereología
