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[Role of the monooxygenase system in the metabolism and mechanism of action of several pesticides]. / Rol' monooksigenaznoi sistemy v metabolizme i mekhanizme deistviia nekotorykh pestitsidov.

Kagan, Iu S; Ershova, E A; Leonenko, O B; Klisenko, M A; Zhmin'ko, P G.

Vestn Akad Med Nauk SSSR ; (1): 70-6, 1988.

Article in Russian | MEDLINE | ID: mdl-3364010

Subject(s)

Liver/enzymology , Mixed Function Oxygenases/metabolism , Pesticides/toxicity , Animals , Biotransformation , Pesticides/metabolism , Rats

[Activity of NADPH-dependent monooxygenase hydroxylating system of rat liver under the effect of tetramethylthiuramdisulfide]. / Aktivnost' NADPH-zavisimoi monooksigenaznoi gidroksiliruiushchei sistemy pecheni krys pri vozdeistvii tetrametiltiuramdisul'fida.

Leonenko, O B; Kuz'minskaia, U A.

Ukr Biokhim Zh (1978) ; 55(5): 574-6, 1983.

Article in Russian | MEDLINE | ID: mdl-6415882

ABSTRACT

Changes in the activity of a NADPH-dependent monooxygenase system of the rat liver are studied under the effect of tetramethylthiuramdisulphide. Under these conditions aniline hydroxylation is shown to be inhibited to a higher extent than amidopyrine demethylation. Besides a decrease in the level of cytochrome P-450, the central component of the microsomal system of hydroxylation, there appears cytochrome P-420--an inactivated form of cytochrome P-450.

Subject(s)

Aniline Hydroxylase/metabolism , Aryl Hydrocarbon Hydroxylases/metabolism , Liver/enzymology , NADPH-Ferrihemoprotein Reductase/metabolism , Aminopyrine N-Demethylase/metabolism , Animals , Hydroxylation , Kinetics , Liver/drug effects , Male , Rats

[Methodological approaches to the study of the state of the monooxygenase hydroxylating system of the liver]. / Nekotorye metodicheskie podkhody k izucheniiu sostoianiia monooksigenaznoi gidroksiliruiushchei sistemy pecheni.

Leonenko, O B.

Gig Sanit ; (4): 54-5, 1983 Apr.

Article in Russian | MEDLINE | ID: mdl-6190706

Subject(s)

Liver/enzymology , Oxygenases/metabolism , Aminopyrine/pharmacology , Aminopyrine/urine , Animals , Enzyme Activation/drug effects , Female , Hexachlorocyclohexane/pharmacology , Hydrolysis , Liver/drug effects , Male , Methods , Phenobarbital/pharmacology , Rats , Time Factors

[Evaluation of the activity of the hydroxylating monooxygenase system by the excretion of amidopyrine metabolites]. / Otsenka aktivnosti gidroksiliruiushchei monooksigenaznoi sistemy po ékskretsii metabolitov amidopirina.

Leonenko, O B; Kaskevich, L M.

Vrach Delo ; (2): 103-5, 1983 Feb.

Article in Russian | MEDLINE | ID: mdl-6845683

Subject(s)

Aminopyrine/urine , Liver/enzymology , Mixed Function Oxygenases/metabolism , Adult , Carbamates , Environmental Exposure , Female , Humans , Inactivation, Metabolic , Insecticides/metabolism , Male , Methods , Middle Aged

[Method of assessing liver oxidase activity]. / Metod otsenki aktivnosti oksidaz pecheni.

Popov, T A; Leonenko, O B.

Gig Sanit ; (9): 56-9, 1977 Sep.

Article in Russian | MEDLINE | ID: mdl-908527

Subject(s)

Liver/enzymology , Oxidoreductases/analysis , Acetylation , Aminopyrine , Animals , Biotransformation/drug effects , Clinical Enzyme Tests/methods , Colorimetry , Enzyme Activation/drug effects , Humans , Liver/drug effects , Methylation , Rats

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