1.
Bioorg Med Chem Lett
; 18(6): 1926-30, 2008 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-18308567
ABSTRACT
A series of novel acylsulfonamide, acylsulfamide, and sulfonylurea bioisosteres of carboxylic acids were prepared as CXCR2 antagonists. Structure-activity relationships are reported for these series. One potent orally bioavailable inhibitor had excellent PK properties and was active in a lung injury model in hyperoxia-exposed newborn rats.