ABSTRACT
Deitiforin in HEp-2 cell culture was shown to inhibit replication of the reference PIV-3 strain when administered 1 hour before virus inoculation. The most marked effect of the drug was observed in the first 4 days of observation. In experimental newborn mice infected with parainfluenza virus 3 deitiforin protected the animals from developing the infection. In humans given deitiforin reaction to vaccination was found to develop 5-6 times more rarely than in the control group, PIV-3 could be isolated twice as rarely, and a diagnostically significant rise of specific antibody levels was observed less frequently.
Subject(s)
Antiviral Agents/therapeutic use , Parainfluenza Virus 3, Human , Paramyxoviridae Infections/drug therapy , Adult , Animals , Animals, Suckling , Antibodies, Viral/blood , Cell Line , Cells, Cultured/drug effects , Cells, Cultured/microbiology , Drug Evaluation , Drug Evaluation, Preclinical , Humans , Mice , Organic Chemicals , Parainfluenza Virus 3, Human/immunology , Paramyxoviridae Infections/immunology , Time Factors , Viral Vaccines/immunologyABSTRACT
Grippovac SE-AZh a polytype, subunit influenza virus vaccine containing H1N1 and H3N2 influenza A virus strains and one influenza B virus strain has been tested in 80 volunteers. The trials demonstrated the harmlessness, the absence of adverse reactions, and except of the B type, the high antigenicity of vaccine preparation when administered in two injections. The optimal dose of each viral strain haemagglutinin (HA) was 15 micrograms in 0.5 ml.
Subject(s)
Influenza Vaccines/immunology , Adult , Antigens, Viral/analysis , Fever/etiology , Humans , Immunity , Influenza A virus/immunology , Influenza B virus/immunology , Influenza Vaccines/adverse effects , VaccinationABSTRACT
Extensive clinical data demonstrate that the use of remantadine for the treatment of ambulant influenza patients during the epidemic of influenza, types A and B, proved to be effective, which was manifested by an essential increase in the number of complications, mainly in the respiratory organs, and by a reduced length of the disease. The positive result of the curative action of remantadine is believed to be connected with the simultaneous wide circulation of type A (H1N1) and (H3N2) influenza viruses.
Subject(s)
Adamantane/analogs & derivatives , Ambulatory Care , Disease Outbreaks , Influenza, Human/drug therapy , Rimantadine/therapeutic use , Absenteeism , Disease Outbreaks/epidemiology , Drug Evaluation , Humans , Influenza, Human/complications , Influenza, Human/epidemiology , Russia , Urban PopulationABSTRACT
In this work the multiple puncture method (in 76 cases) was compared with the scarification method--2 clinear cuts (in 70 cases). "Vaccine take" of the vaccines demonstrated a statistically significant difference: by the first method the percentage of personal "vaccine take" was 98.7, and by the second--86.4. The multiple puncture method produced a less pronounced local and general reaction. Immunological efficacy of the multiple puncture method (evaluated by hemagglutination inhibition test and neutralization test in the tissue culture) was quite satisfactory and failed to differ from such in vaccination by scarification.
Subject(s)
Punctures/methods , Smallpox Vaccine/administration & dosage , Vaccination/methods , Child, Preschool , Follow-Up Studies , Humans , Infant , Smallpox/immunologyABSTRACT
Studies on animals demonstrated that in experimental herpetic encephalitis there is a diffuse retardation of background bioelectric brain activity and a proxysmal activity of 2 types: peek complex-slow waves 3 per 1 sec. and periodical paroxysmal complexes. There is also an increase of latent periods, duration and amplitudes of visual evoked potentials. Electrophysiological data correlate with the clinical picture of herpetic encephalitis and pathomorphological changes in the CNS. The obtained data are discussed with consideration bor the theory of neuron epileptization and hemodynamical disturbances.
