ABSTRACT
Data are presented on the results of photodynamic treatment (PDT) of mice DBA2 with transplantable lympho-leukemia P-388. Different regimens of photosensitizer Dimegin and emission were used. Both intravenous PDT and in combination with local PDT should be recommended.
Subject(s)
Deuteroporphyrins/therapeutic use , Leukemia, Experimental/drug therapy , Lymphoma/drug therapy , Photosensitizing Agents/therapeutic use , Animals , Mice , Mice, Inbred DBA , Neoplasms, Experimental/drug therapy , Photochemotherapy/instrumentation , Photochemotherapy/methods , Transplantation, Heterologous , Treatment OutcomeABSTRACT
Biological effects of Lamipharen treatment of sarcoma M-1 was studied in newborn rats and photodynamic therapy in combination with radiation was evaluated.
Subject(s)
Low-Level Light Therapy , Photochemotherapy , Photosensitizing Agents/therapeutic use , Sarcoma, Experimental/drug therapy , Animals , Animals, Newborn , Photochemotherapy/adverse effects , Photochemotherapy/methods , Photosensitizing Agents/administration & dosage , Photosensitizing Agents/adverse effects , Radiotherapy, Adjuvant , Rats , Rats, Wistar , Sarcoma, Experimental/radiotherapyABSTRACT
The relation between the antenatal and early postnatal ontogenesis of the progeny and the degree of maturity of oocytes at the time of the whole single gamma-irradiation with doses of 0.25, 0.5 and 1 Gy was studied on 473 first pregnant Wistar rats and 1402 rats of the first generation. Ontogenesis disorders ot the progeny of these females after irradiation of the matured oocytes were more marked than after irradiation of the maturing oocytes. The distinction was noticeable after a dose of 0.25 Gy.
Subject(s)
Embryonic and Fetal Development/radiation effects , Maternal Exposure/adverse effects , Oocytes/radiation effects , Oogenesis/radiation effects , Animals , Animals, Newborn , Body Mass Index , Cobalt Radioisotopes , Female , Pregnancy , Radiation Dosage , Rats , Rats, Wistar , Time FactorsABSTRACT
Distinct genetic radiosensitivity of germinal cells of males irradiated during different stages of spermatogenesis with doses of 0.25-5.0 Gy leads to reduction in vital newborn rats number in the first generation progeny and to elevated postnatal mortality rate. These postnatal ontogeny disorders depend on the irradiation dose and spermatogenesis stage for a moment irradiation.
Subject(s)
Growth/radiation effects , Spermatogenesis/radiation effects , Spermatozoa/radiation effects , Animals , Dose-Response Relationship, Radiation , Fathers , Gamma Rays , Litter Size/radiation effects , Male , Radiation Tolerance , Rats , Rats, WistarABSTRACT
Single whole-body exposure of adult male rats Wistar in different stages of spermatogenesis to gamma-rays (doses from 0.25 to 5.00 Gy) resulted in violations of antenatal development of the first generation offsprings. The pronouncement of these violations depends on the spermatogenesis stage in the moment of irradiation and exposure dose.
