1.
Acta Pol Pharm
; 65(3): 377-81, 2008.
Article
in English
| MEDLINE
| ID: mdl-18646558
ABSTRACT
Five substituted amides of lysine with the general formula: X-Lys-NH-Y, where X= acetyl or ethoxycarbonyl, Y= cyclohexyl, benzyl, hexyl or cadaverine residue were synthesised and their effects on fibrinolytic activity of plasmin, clotting activity of thrombin and amidolytic activities of both enzymes were examined.
Subject(s)
Amides/chemical synthesis , Fibrinolysin/antagonists & inhibitors , Lysine/analogs & derivatives , Thrombin/antagonists & inhibitors , Amides/pharmacology , Blood Coagulation/drug effects , Blood Coagulation/physiology , Fibrinolysis/drug effects , Fibrinolysis/physiology , Lysine/pharmacology , Structure-Activity Relationship
2.
Acta Pol Pharm
; 63(1): 33-7, 2006.
Article
in English
| MEDLINE
| ID: mdl-17515327
ABSTRACT
Four dipeptide alkylamides with general formula H-D-Phe-L-Lys-NH-X, where X = cyclohexyl, - (CH2)5NH2, -(CH2)2-OH and hexyl were obtained. Effect of these compounds on amidolytic and fibrinolytic activity of plasmin was examined.
