Current trends in pedicle screw stimulation techniques: lumbosacral, thoracic, and cervical levels.

Unequivocally, pedicle screw instrumentation has evolved as a primary construct for the treatment of both common and complex spinal disorders. However an inevitable and potentially major complication associated with this type of surgery is misplacement of a pedicle screw(s) which may result in neural and vascular complications, as well as impair the biomechanical stability of the spinal instrumentation resulting in loss of fixation. In light of these potential surgical complications, critical reviews of outcome data for treatment of chronic, low-back pain using pedicle screw instrumentation concluded that "pedicle screw fixation improves radiographically demonstrated fusion rates;" however the expense and complication rates for such constructs are considerable in light of the clinical benefit (Resnick et al. 2005a). Currently, neuromonitoring using free-run and evoked (triggered) electromyography (EMG) is widely used and advocated for safer and more accurate placement of pedicle screws during open instrumentation procedures, and more recently, guiding percutaneous placement (minimally invasive) where the pedicle cannot be easily inspected visually. The latter technique, evoked or triggered EMG when applied to pedicle screw instrumentation surgeries, has been referred to as the pedicle screw stimulation technique. As concluded in the Position Statement by the American Society of Neurophysiological Monitoring (ASNM), multimodality neuromonitoring using free-run EMG and the pedicle screw stimulation technique was considered a practice option and not yet a standard of care (Leppanen 2005). Subsequently, the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Joint Section on Disorders of the Spine and Peripheral Nerves published their "Guidelines for the Performance of Fusion Procedures for Degenerative Disease of the Lumbar Spine" (Heary 2005, Resnick et al. 2005a, Resnick et al. 2005b). It was concluded that the "primary justification" of intraoperative neuromonitoring"... is the perception that the safety and efficacy of pedicle screw fixation are enhanced..." (Resnick et al. 2005b). However in summarizing a massive (over 1000 papers taken from the National Library of Medicine), contemporary, literature review spanning nearly a decade (1996 to 2003), this invited panel (Resnick et al. 2005b) recognized that the evidence-based documents contributing to the parts related to pedicle screw fixation and neuromonitoring were "... full of potential sources of error ..." and lacked appropriate, randomized, prospective studies for formulating rigid standards and guidelines. Nevertheless, current trends support the routine use and clinical utility of these neuromonitoring techniques. In particular free-run and triggered EMG have been well recognized in numerous publications for improving both the accuracy and safety of pedicle screw implantation. Currently, treatment with pedicle screw instrumentation routinely involves all levels of the spine - lumbosacral, thoracic, and cervical. Significant historical events, various neuromonitoring modalities, intraoperative alarm criteria, clinical efficacy, current trends, and caveats related to pedicle screw stimulation along the entire vertebral column will be reviewed.

Monitoring spinal nerve function with H-reflexes.

H-reflexes have been used in the clinical neurophysiology laboratory for some time to assess patients with neuromuscular disorders. There are only a few reports for the application of H-reflexes for intraoperative neurophysiologic monitoring. The goals of this article are to review the intraoperative neurophysiologic monitoring of spinal nerve root function with H-reflexes. The following will be reviewed: (1) Introduction to H-reflexes, (2) pathophysiology of spinal nerve root function, (3) neurophysiologic basis of H-reflexes, (4) gastrocnemius H-reflex, (5) flexor carpi radialis H-reflex, (6) anesthetic technique and research, and (7) intraoperative applications of H-reflexes. H-reflexes are single sweep real-time recordings that provide immediate feedback to the surgeon. They can be used to monitor not only sensory and motor spinal nerve root function but also peripheral sensory and motor nerves, plexus, and postsynaptic spinal cord gray matter function.

Intraoperative applications of the H-reflex and F-response: a tutorial.

Traditional intraoperative monitoring of spinal cord function involves the use of three techniques: 1. Orthodromic ascending somatosensory evoked potentials (SSEPs) and 2. antIDromic descending neurogenic somatosensory evoked potentials (DNSSEPs) monitor long-tract sensory function. SSEPs and DNSSEPs do not monitor interneuronal gray matter function. 3. Transcranial motor evoked potentials (TMEPs) monitor descending long-tract motor function and measure interneuronal gray matter function by activating motor neurons. TMEPs activate from 4-5% of the motor neuron pool. When using TMEPs 95-96% of the motor spinal cord systems activating the motor neurons are not monitored. Our ability to interact with our environment involves not only intact sensation and strength, but also complex coordinated motor behavior. Complex coordinated motor behavior is controlled by groups of electrically-coupled spinal cord central pattern generators (CPGs). The components of CPGs are: descending and propriospinal systems, peripheral input, and segmental interneurons. The point-of-control is the level of excitation of interneurons, which is determined by the integrated activity of the other components. Spinal cord injury (SCI) changes segmental reflex gain by uncoupling these components. Changes in gain are detected by recordings from muscles. SSEPs, DNSSEPs and TMEPs provIDe limited information about the status of CPGs. H-reflexes measure the function of from 20-100% of the motor neuron pool. F-responses measure the function of from 1-5% of the motor neuron pool. H-reflexes and F-responses provIDe information about the degree of coupling between CPG components. Recording H-reflexes and F-responses together with SSEPs and TMEPs not only monitors spinal cord long-tract function, but also provIDes a multiple-systems approach that monitors those spinal cord systems that are responsible for the control of complex coordinated motor behavior. The objective of this paper is to describe how H-reflexes and F-responses can be used to monitor complex coordinated motor behavior.

Intraoperative monitoring of segmental spinal nerve root function with free-run and electrically-triggered electromyography and spinal cord function with reflexes and F-responses. A position statement by the American Society of Neurophysiological Monitoring.

BACKGROUND CONTEXT: Orthodromic ascending somatosensory evoked potentials and antidromic descending neurogenic somatosensory evoked potentials monitor spinal cord sensory function. Transcranial motor stimulation monitors spinal cord motor function but only activates 4-5% of the motor units innervating a muscle. Therefore, 95-96% of the motor spinal cord systems activating the motor units are not monitored. To provide more comprehensive monitoring, 11 techniques have been developed to monitor motor nerve root and spinal cord motor function. These techniques include: 1. neuromuscular junction monitoring, 2. recording free-run electromyography (EMG) for monitoring segmental spinal nerve root function, 3. electrical stimulation to help determine the correct placement of pedicle screws, 4. electrical impedance testing to help determine the correct placement of pedicle screws, 5. electrical stimulation of motor spinal nerve roots, 6. electrical stimulation to help determine the correct placement of iliosacral screws, 7. recording H-reflexes, 8. recording F-responses, 9. recording the sacral reflex, 10. recording intralimb and interlimb reflexes and 11. recording monosynaptic and polysynaptic reflexes during dorsal root rhizotomy. OBJECTIVE: This paper is the position statement of the American Society of Neurophysiological Monitoring. It is the practice guideline for the intraoperative use of these 11 techniques. METHODS: This statement is based on information presented at scientific meetings, published in the current scientific and clinical literature, and presented in previously-published guidelines and position statements of various clinical societies. RESULTS: These 11 techniques when used in conjunction with somatosensory and transcranial motor evoked potentials provide a multiple-systems approach to spinal cord and nerve root monitoring. CONCLUSIONS: The techniques reviewed in this paper may be helpful to those wishing to incorporate these techniques into their monitoring program.