1.
Angew Chem Int Ed Engl
; 38(24): 3680-3683, 1999 Dec 16.
Article
in English
| MEDLINE
| ID: mdl-10649323
ABSTRACT
The circumvention of efficient "carbohydrate traps" in the liver is required for targeting glycoconjugates on tumor cells. As shown in the model system of bovine serum albumin (BSA) conjugates, the nature of R(1)-R(3) of the fucose epitope plays an important role in the discrimination of cellular uptake between tumor and liver cells as well as in the cytotoxic activity.