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1.
Neurochirurgie ; 68(4): 379-385, 2022 Jul.
Article in English | MEDLINE | ID: mdl-35123987

ABSTRACT

BACKGROUND: Some authors used minimally invasive surgery (MIS) in the treatment of spinal cord tumor, but these studies had a small sample sizes and mixed extra- and intra-medullary tumors, resulting in confounding biases. The objectives of the present study were to evaluate the effectiveness and safety of MIS for spinal meningioma resection in comparison with open surgery (OS). METHODS: Consecutive patients with spinal meningioma who received either MIS or OS were included. Data for extent of resection, functional outcome, postoperative morbidity and recurrence were collected. RESULTS: A total of 48 patients (with 51 spinal meningiomas) were included. Eighteen underwent MIS and 30 OS. Meningioma volume and location did not differ significantly between groups: tumors were predominantly thoracic (n=39, 76.5%) and voluminous (occupying more than 50% of the spinal canal: n=43, 84.3%). In the MIS group, patients were older (mean age: 66.5 vs. 56.4years, P=0.02) and more fragile (mean ASA score: 2.0 vs. 1.6, P=0.06). In the MIS group, the surgical procedure was shorter (mean duration: 2.07 vs. 2.56h, P=0.04), blood loss lower (mean: 252 vs. 456mL, P=0.02), and hospital stay shorter (mean: 6.6 vs. 8.1days). Surgery improved the modified McCormick scale (P<0.0001) irrespective of the surgical technique. MIS led to no significant differences in extent of resection or postoperative morbidity. Mean follow-up was 46.6 months. At last follow-up, 91.7% (n=44) of patients were free of progression; all cases of tumor progression (n=4) occurred in the OS group. CONCLUSIONS: MIS outperformed OS in the management of intradural spinal meningioma, irrespective of location and volume. MIS appears to be particularly suitable for elderly and fragile patients.


Subject(s)
Meningeal Neoplasms , Meningioma , Aged , Humans , Meningeal Neoplasms/surgery , Meningioma/surgery , Minimally Invasive Surgical Procedures/methods , Retrospective Studies , Treatment Outcome
2.
Neurochirurgie ; 66(4): 195-202, 2020 Aug.
Article in English | MEDLINE | ID: mdl-32645393

ABSTRACT

INTRODUCTION: The management of antithrombotic therapy (AT) after surgery for chronic subdural hematoma (cSDH) requires taking account of the balance of risk between hemorrhage recurrence (HR) and the prophylactic thromboembolic effect (TE). The goal of the present study was to evaluate the prevalence of vascular events (VE: TE and/or HR) in the first 3 postoperative months after cSDH evacuation in patients previously treated by AT. The impact of AT resumption was also evaluated. PATIENTS AND METHODS: This observational prospective multicenter collaborative study (14 French neurosurgery centers) included patients with cSDH treated by AT and operated on between May 2017 and March 2018. Data collection used an e-CRF, and was principally based on an admission questionnaire and outcome/progression at 3 months. RESULTS: In this cohort of 211 patients, VE occurred in 58 patients (27.5%): HR in 47 (22.3%), TE in 17 (8%), with mixed event in 6 cases (2%). Median overall time to onset of complications 26 days±31.5, and specifically 43.5 days±29.25 for HR. Non-resumption of AT significantly increased the relative risk of VE [OR: 4.14; 95% CI: 2.08 - 8.56; P <0.001] and especially of TE [OR: 7.5; 95% CI: 1.2 - 42; P<0.001]. The relative risk of HR was significantly increased when AT was resumed at less than 30 days (P=0.015). CONCLUSION: The occurrence of VE in patients operated on for cSDH and previously treated by AT was statistically significant (27.5%). HR was the most common event (22.3%), whereas TE accounted for only the 8%, although with shorter time to onset. In order to prevent TE risk, AT should be restarted after 30 days, as HR risk is greatly decreased beyond this time.


Subject(s)
Fibrinolytic Agents/therapeutic use , Hematoma, Subdural, Chronic/surgery , Aged , Aged, 80 and over , Drainage , Female , France , Hematoma, Subdural, Chronic/prevention & control , Humans , Longitudinal Studies , Male , Neurosurgical Procedures , Postoperative Complications/epidemiology , Prevalence , Prospective Studies , Recurrence , Risk Factors , Surveys and Questionnaires , Treatment Outcome
3.
Neurochirurgie ; 64(3): 155-160, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29754739

ABSTRACT

BACKGROUND: High-field intraoperative MRI (IoMRI) is a useful tool to improve the extent of glioma resection (EOR). OBJECTIVE: To compare the interest of 1.5T IoMRI in glioma surgery between enhancing and non-enhancing tumors, based on volumetric analysis. METHODS: A prospective single-center study included consecutive adult patients undergoing glioma surgery with IoMRI. Volumetric evaluation was based on FLAIR hypersignal after gadolinium injection in non-enhancing tumors and T1 hypersignal after gadolinium injection in enhancing tumors. Endpoints comprised: residual tumor volume (RTV), EOR, workflow and clinical outcome on Karnofsky performance score (KPS). RESULTS: Fifty-three surgeries were performed from July 2014 to January 2016. Thirty-four patients underwent one IoMRI, and 19 two IoMRIs. In non-enhancing tumors, intraoperative RTV on 1st IoMRI T2/FLAIR was higher than in enhancing tumors on T1 sequences (7.25cm3 vs. 0.74cm3, respectively; P=0.008), whereas the RTV on 2nd IoMRIs and final RTV were no longer significantly different. After IoMRI, 72% of patients underwent additional resection. In non-enhancing tumors, EOR increased from 77.3% on 1st IoMRI to 97.4% on last MRI (P<0.001). Taking all tumors together, final RTV values were: median=0cm3, mean=3.9cm3. Mean final EOR was 94%. In 25% of patients, KPS was reduced during early postoperative course; at 3 and 6 months postoperatively, median KPS was 90. CONCLUSION: Intraoperative MRI guidance significantly enhanced the extent of glioma resection, especially for non- or minimally enhancing tumors, while preserving patient autonomy.


Subject(s)
Brain Neoplasms/surgery , Glioma/surgery , Magnetic Resonance Imaging , Neoplasm, Residual/surgery , Adult , Aged , Brain Neoplasms/pathology , Female , Gadolinium , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Prospective Studies , Treatment Outcome , Young Adult
4.
Neurochirurgie ; 63(3): 181-188, 2017 Jun.
Article in English | MEDLINE | ID: mdl-28571707

ABSTRACT

BACKGROUND: The aim of our study was to report the usefulness of intraoperative MRI guidance in the resection of brain lesions adjacent to eloquent areas. PATIENTS AND METHODS: A single center prospective series of gliomas amenable to optimized resection with intraoperative MRI between September 2014 and December 2015. RESULTS: The study included 56 patients. The median duration of the first intraoperative MRI was 38min, interquartile range (IQR 30-46). Fourteen patients (40%) underwent a second intraoperative MRI, which had a median duration of 26min (IQR, 18-30). The median total operative time was 265min (IQR, 242-337). After the first intraoperative MRI, the median residual glioma volume of the 35 gliomas adjacent to eloquent areas was 7.04cm3 (IQR, 2.22-13.8), which did not significantly differ from the other gliomas (P=0.07). After the second intraoperative MRI, the median residual glioma volume was 3.86cm3 (IQR, 0.82-6.99), which did not significantly differ from the other patients (P=0.700). On the postoperative MRI, the median extent of the glioma resections adjacent to eloquent areas was 99.78% (IQR, 88.9-100), which was not significantly different from the rest of the population (P=0.290). At 6 months after surgery, the median Karnofsky Performance Score was 90, and 2.8% of the patients presented a permanent new neurological deficit. CONCLUSION: Our results suggest that intraoperative MRI is an effective and safe technique to improve the extent of brain lesion resections close to eloquent areas.


Subject(s)
Brain Neoplasms/surgery , Brain/surgery , Glioma/surgery , Magnetic Resonance Imaging , Monitoring, Intraoperative , Adolescent , Adult , Brain Neoplasms/diagnostic imaging , Brain Neoplasms/physiopathology , Female , Glioma/diagnostic imaging , Glioma/physiopathology , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Monitoring, Intraoperative/methods , Neuronavigation/methods , Prospective Studies
5.
Neurochirurgie ; 57(4-6): 180-92, 2011.
Article in French | MEDLINE | ID: mdl-22019219

ABSTRACT

Lateral ventricular neoplasms are rare, and account for 50% of all intraventricular tumors in adults and 25% in children. Although these neoplasms are easily detected with computed tomography (CT) and magnetic resonance imaging (MRI), both techniques are relatively unspecific in identifying the type of tumor. However, few imaging patterns are specific for a particular pathological process and useful conclusions can be made from the morphological appearance of the lesion, its location and enhancement pattern. The aim of this article was to review and illustrate the CT and MRI findings of a wide spectrum of tumors of the lateral ventricle. We reviewed choroid plexus tumors, meningioma, subependymal giant cell astrocytoma, central neurocytoma, and less frequent lesion such as lymphoma and metastases.


Subject(s)
Cerebral Ventricle Neoplasms/diagnostic imaging , Cerebral Ventricle Neoplasms/pathology , Lateral Ventricles/diagnostic imaging , Lateral Ventricles/pathology , Astrocytoma/diagnostic imaging , Astrocytoma/pathology , Choroid Plexus Neoplasms/diagnostic imaging , Choroid Plexus Neoplasms/pathology , Choroid Plexus Neoplasms/secondary , Diffusion Magnetic Resonance Imaging , Ependymoma/diagnostic imaging , Ependymoma/pathology , Giant Cell Tumors/diagnostic imaging , Giant Cell Tumors/pathology , Glioma, Subependymal/diagnostic imaging , Glioma, Subependymal/pathology , Humans , Image Processing, Computer-Assisted , Lymphoma/diagnostic imaging , Lymphoma/pathology , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , Meningioma/diagnostic imaging , Meningioma/pathology , Neurocytoma/diagnostic imaging , Neurocytoma/pathology , Preoperative Care , Tomography, X-Ray Computed
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