[The results of hypofractionated irradiation in patients with bronchogenic carcinoma]. / Ergebnisse hypofraktionierter Bestrahlung bei Patienten mit Bronchialkarzinom.

Resulting from the declared palliative aim and from time economic and tumor affecting high dosed single fraction meanwhile a hypofractionated irradiation rhythm was applied to more than 500 patients with lung carcinoma and 5 x 5 Gy were given in daily succession if possible. A hospitalization was necessary in a third of the patients. In spite of histology (NSCLC: 46%, SCLC: 35%) a mean survival of 12 months was attained, in which the fate is determined for 75% of the patients within the first year after therapy. Detrimental effects were not provoked by the applied irradiation mode.

Non-Hodgkin's lymphomas--prognostic analysis and therapeutic recommendations.

The total non-Hodgkin's lymphoma-population between 1960 and 1985 treated by means of radiotherapy or combined radio-chemotherapy in the Medical Academy Dresden was analysed prognostically. 247 patients were classified according to previous scheme, 79 were subdivided on the basis of the recommendations of the Kiel-classification. The remission rates and survival curves achieved bear comparison with international literature (remission rates for the low-malignancy group = 85.3% and for the high-malignancy group = 80.0%; 5-year survival rates for the low-malignancy group = 61.9% and for the high-malignancy group = 41.7%). The influence of histology, clinical stage and involvement of organs is discussed according to our results and information from appropriate reference sources. Our analysis confirms the high importance of a common radiologic-internal outpatient department for coordination of the diagnostic and therapeutic programme. Principles of treatment are presented with special respect to polychemotherapy.

[Primary extranodular non-Hodgkin's lymphomas--observations on etiopathogenesis, histology and prognosis]. / Primär extranoduläre Non-Hodgkin-Lymphome--Betrachtungen zur Atiopathogenese, Histologie und Prognose.

The total non-Hodgkin's lymphoma-population treated between 1978 and 1986 by means of radiotherapy or combined chemo/radiotherapy was analysed as to primary extranodular manifestation. 39 cases, 16 women and 23 men, were observed (stage IE 12, stage IIE 22 and stage IIIE 5). Immunoblastic (10), lymphoblastic (9) and centroblastic (6) lymphomas are the most frequent with respect to histology. Gastroenteron (16) and otorhinolaryngological region (13) are in the lead with regard to localisation. 5-year-survival-rates are determined in dependence on clinical stage: IE 65.8%, IIE 39.2% (low, connected with the proportion of high-malignant histology) and IIIE 25.0%. The 5-year-survival-rate of primary gastrointestinal manifestation amounted to 51.5%. With respect to aetiopathogenesis of primary extranodular lymphomas gut-, mucosa- and bronchial-associated lymphoid tissue, aberrant lymph-nodes and the influence of viral- and immunologic factors seem to be important.

[Prognosis of non-Hodgkin's lymphomas in the Dresden district with special reference to combined radio-/chemotherapy]. / Die Prognose der Non-Hodgkin-Lymphome im Bezirk Dresden unter besonderer Berücksichtigung der kombinierten Radio-/Chemotherapie.

The total population affected with non-Hodgkin's lymphoma and treated by means of radiotherapy or combined radio-chemotherapy between 1960 and 1985 at the Medical Academy Dresden was analysed as to prognosis. 247 patients were classified according to the previous German scheme, 79 were subdivided on the basis of the recommendations laid down in the Kiel classification. The remission rates and survival curves achieved will stand out the comparison with international literature (remission rates of the low malignancy group amounted to 85.3 p.c. and those of the high malignancy group to 80.0 p.c.; the 5-years survival rates of the low malignancy group amounted to 61.9 p.c. and those of the high malignancy group to 41.7 p.c.). The influence of histology, clinical stage and involvement of organs is discussed on the basis of our results and informations obtained in literature. Our analysis confirms the high importance which must be attached to a common radiologic-internal outpatient-department for co-ordinating the diagnostic and therapeutical programme.