ABSTRACT
Some aspects related with research and development of a key functional unit of the hemodilysis apparatus with the electrochemical regeneration of dialyzate, i.e. the electrochemical oxidation unit which enables a regulated electrochemical oxidation of the main organic hemodilysis products in the waste dialyzate, are described.
Subject(s)
Hemodialysis Solutions/chemistry , Renal Dialysis/instrumentation , Creatinine/blood , Creatinine/metabolism , Electrochemistry , Humans , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/metabolism , Kidney Failure, Chronic/therapy , Kidneys, Artificial , Oxidation-Reduction , ResearchABSTRACT
The results of a study of parameters of an experimental dialyzate regeneration unit (a key functional unit of a hemodialysis apparatus with the regeneration of dialyzing solution) are discussed in the article.
Subject(s)
Hemodialysis Solutions/chemistry , Renal Dialysis/instrumentation , Calcium/blood , Chlorine/blood , Creatinine/blood , Electrochemistry , Humans , Hydrogen-Ion Concentration , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/metabolism , Kidney Failure, Chronic/therapy , Kidneys, Artificial , Kinetics , Magnesium/blood , Phosphorus/blood , Potassium/blood , Sodium/blood , Urea/blood , Uric Acid/bloodABSTRACT
Radical improvements in the physiological features and self-sufficiency of hemodialysis equipment, an essential reduction of the volume of dialyzate contacting with patient's body and elimination of dependence of the equipment operation on the availability of a water-supply network can be ensured by applying a regime of circulation of a relatively small volume (3-5 l) of dialyzate through the regenerating device. The regeneration unit must eliminate the organic products of dialysis from the dialyzate and stabilize the ionic composition of the purified dialyzate according to the preset parameters. Modern methods and technical means for regenerating the used dialyzate are discussed; a regeneration unit, which ensures an electrochemical oxidation (in the used dialyzate) of nitrogen-containing organic metabolites with a subsequent sorption-type additional purification of electrochemically-processed dialyzate, is offered. The regeneration unit is made up of an electrolyser, a sorption-type additional-purification device and a gas utilizer; it eliminates organic metabolites, phosphorus, calcium and potassium from the used dialyzate and stabilizes the pH solution.
Subject(s)
Hemodialysis Solutions/chemistry , Renal Dialysis/instrumentation , Renal Dialysis/trends , Calcium/blood , Electrochemistry , Humans , Hydrogen-Ion Concentration , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/metabolism , Kidney Failure, Chronic/therapy , Kidneys, Artificial , Oxidation-Reduction , Phosphorus/blood , Potassium/blood , RussiaABSTRACT
Controlled removal of the present quantities of renal metabolites from the waste dialysate can be effected by electrochemical regeneration of the worked-out dialysate, which is based on the use of a dialyzing solution electrolyzer (DSE). A theoretical rationale for DSE functioning modes has been provided. A reaction model of urea oxidation on bimetallic titanium-platinum electrodes has been drawn up. A procedure for calculating the basic technical data of DSE is proposed. The paper presents the design and experimental findings of a 4-section monopolar electrolyzer with electrode parallel-series connection that ensures discrete control of the electrolyzer's anode current provided that the preset anode current density is preserved.
Subject(s)
Artificial Organs , Electrochemistry/instrumentation , Kidney , Dialysis SolutionsABSTRACT
The clinical efficiency, safety and accessibility of a lot of artificial blood clearance procedures are provided by the versatility of equipment operational capacities, computerization, automatization, expendable blood-conducting elements, higher independence through the electrochemical regeneration of a dialyzing solution, a reduced range of the hardwares used and their simplified designing implementation. A clearance technique-invariant pattern of polyblock of technical equipment with a universal perfusion unit wherein perfusion is accompanied by centralized equipment control has been proposed and introduced into practice.