[Epidemiology of Lyme borreliosis]. / Epidemiologija Lyme borreliosis.

Our prospective study covered 1093 patients with epidemiological features and demonstrable clinical manifestations of Lyme borreliosis from 1987 to 1992. Basic criteria for the inclusion of our patients in the study were: tick bite, erythema migrans and antibodies to B. burgdorferi in each patient's serum. Various clinical manifestations were found un 1034 (94.6%) patients out of whom 829 (80.2%) had a history of tick bite, 901 (87.1%) had erythema migrans and 217 (21.0%) had serologic confirmation of the diagnosis. Inapparent infection was discovered in 59 (5.4%) patients. Other Types of skin changes (II and III stage) were found in 123 (11.9%) patients. The disease resulted in neurologic, joint and cardiac manifestations in somewhat lower percentage of patients (6.3%, 6.6% and 1.5%, respectively). In the three-year period (1990-1992) microscopic examination of the ticks (Ixodes ricinus) collected at several green areas of Belgrade confirmed the presence of B. burgdorferi in 29.1 per cent.

[Clinical characteristics of patients with Lyme disease treated at the Institute for Infective and Tropical Diseases 1988-1992]. / Klinicke karakteristike obolelih od lajmske bolesti lecenih u Institutu za infektivne i tropske bolesti od 1988. do 1992. godine.

In the Institute for infectious and tropical diseases in Belgrade in the period 1988-1992, 680 patients with Lyme borreliosis have been examined. In most cases illness was recognised in the first stage as Erythema migrans. In seven patients second and third stage of Lyme borreliosis was cured in hospital.

[Clinico-laboratory diagnosis of Lyme borreliosis--personal experience]. / Klinicko-laboratorijska dijagnoza Lyme borreliosis--nasa iskustva.

Between May 1992 and February (second half) 1993 two hundred patients with the history of tick bite have been examined at the Institute for Infectious and Tropical Diseases "Dr Kosta Todorovic". Of the above 200 persons, 103 of them have had clinical/epidemiological evidence of Lyme disease (i.e. Erythema migrans). In order to establish the degree of seroconversion in this stage of Lyme disease, blood of each patient has been tested by PHA and IFA methods. Blood from each patient has been drawn in pairs, immediately before and after the treatment. By method of PHA we have analyzed 186 sera and found 23 positive results. By method of IFA we have analyzed 10 sera and found one positive result. By Comparative testing we have analyzed 10 sera, obtaining 5 positive results by PHA and 3 positive results ba IFA.

[Borrelia burgdorferi seropositivity in the region of Cacak]. / Prokuzenost stanovnika regiona Cacak Borelijom burgdorferi.

Seropositivity to Borrelia burgdorferi found in the population of Cacak area, suggests that the illness in different forms is present in this population. Failure in detection of early symptoms contributes to development of the second and the third stage of illness, in which the treatment is connected with more difficulties. A high natural focus activity has been confirmed by seropositivity found in sera of 11% of patients tested.