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Nouv Rev Fr Hematol (1978) ; 37(2): 171-3, 1995.
Article in English | MEDLINE | ID: mdl-7644357

ABSTRACT

In 34 patients with peripheral occlusive arterial disease, circulating levels of endothelial cell markers were compared with the ischemic status. Unlike tissue plasminogen activator and plasminogen activator inhibitor, plasma levels of thrombomodulin were closely related to both transcutaneous oxygen pressure (p = 0.01) and the graded clinical stages of disease (p = 0.02). Levels of von Willebrand factor were correlated only with the transcutaneous oxygen pressure (p = 0.04). Since thrombomodulin and von Willebrand factor constitute markers of endothelial cell damage, the extent of endothelial injury would appear to be determined by the ischemic status.


Subject(s)
Arterial Occlusive Diseases/physiopathology , Peripheral Vascular Diseases/physiopathology , Thrombomodulin/analysis , von Willebrand Factor/analysis , Aged , Aged, 80 and over , Arterial Occlusive Diseases/metabolism , Biomarkers/blood , Endothelium/metabolism , Endothelium/pathology , Female , Humans , Male , Middle Aged , Oxygen/metabolism , Peripheral Vascular Diseases/metabolism
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