ABSTRACT
Serum contains a factor that can normalize streptozotocin induced blood sugar elevation. This normalization can last for a long period. Thus an elimination of elevated diabetic blood sugar values takes place. This means that an euglycemic factor may have the ability to an eventual curing of diabetes. Normal, starving rats are not influenced by the euglycemic factor. An other factor even aggravates diabetic blood sugar level.
Subject(s)
Diabetes Mellitus, Experimental/therapy , Animals , Biological Factors/physiology , Blood Glucose/drug effects , Blood Glucose/metabolism , Blood Proteins/physiology , Diabetes Mellitus, Experimental/blood , RatsABSTRACT
In one case of diabetes, normal glucose contents and volumes of the urine and high diabetic values alternate with each other. This periodicity may be of short duration (a couple of days), but long-lasting normal state can also occur. This state of aperiodicity may last almost a month. In such "smoothening" of hormone-regulation, some modulator substances may play a role.
Subject(s)
Diabetes Mellitus, Type 1/complications , Glycosuria/complications , Circadian Rhythm , Diabetes Mellitus, Type 1/metabolism , Humans , Male , Middle AgedABSTRACT
It can be shown that a number of substances that are derived from incubation have a good blocking capacity in myocardial infarction. There exists also a natural substance (intrinsic factor, i.f.) which can also block infarction. The same substances also inhibit arrhythmias of ischaemic origin. Thus a common root for myocardial infarction and arrhythmias could be inferred. A new dynamic method (T/2 velocity) was elaborated for evaluating anti-infarction drugs instead of using static T/2 values. Oxidation of i.f. in vitro and in vivo enhances the blocking capacity of artificial drugs reagented previously each other. The natural substance (i.f.) lost its blocking capacity after oxygenation, thus may be unable to compete with the above mentioned artificial substances. Ligation of the coronaries i.e. its myocardial infarction producing effect can also be inhibited by the same substances. No matter how infarction is produced, the same substances can block it. Since after cutting the vagi KCl elicits the same phenomena their reflex origin can be excluded.
Subject(s)
Myocardial Infarction/etiology , Animals , Anti-Arrhythmia Agents/pharmacology , Cats , Female , Hypoxia , Ligation , Male , Myocardial Infarction/drug therapy , Myocardial Infarction/physiopathology , Potassium ChlorideABSTRACT
Solutions of KCl (1%, 10% and 31.2%) administered into the pericardial fluid or applied onto the surface of the heart evoked a dome-like change of the ECG in dogs, rats and guinea-pigs and led to myocardial infarction in 3-5 days. Both the acute changes in ECG and the infarction itself could be prevented by the application of pericardial fluid samples and by administration of three synthetic compounds onto the heart surface. The same substances also inhibited the development of ECG changes elicited by general hypoxia due to stopping artificial respiration. The existence of a peculiar myocardial space beginning with outer pores and reaching the myocardial cells through connective tissue pathways is postulated. Earlier studies showed that 125I-labelled albumin applied to the epicardial surface through a filter paper reached the endomyocardium through some intramyocardial pathways beginning with epicardial pores. In the present experiments intrapericardial application of India ink led to obstruction of these pores and thus prevented the infarction elicited by intrapericardial administration of KCl solutions. This space, being distinct from that accessible from the coronary arteries, serves for transfer of various substances into the myocardium, while other compounds (e.g. noradrenaline) are not effective through this pathway. Oxygen reaching this space from the epicardial surface protects the myocardium from the damaging effects of hypoxia and KCl.
