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Bioorg Med Chem Lett ; 27(7): 1572-1575, 2017 04 01.
Article in English | MEDLINE | ID: mdl-28242274

ABSTRACT

Fluazaindolizine is a new highly effective and selective product for the control of plant parasitic nematodes. Specificity for nematodes coupled with absence of activity against the target sites of commercial nematicides suggests that fluazaindolizine has a novel mode of action. The discovery, structure-activity development and biological properties for this new class of nematicides are presented.


Subject(s)
Heterocyclic Compounds, 2-Ring/pharmacology , Indolizines/pharmacology , Pesticides/pharmacology , Sulfonamides/pharmacology , Animals , Caenorhabditis elegans/drug effects , Crops, Agricultural/parasitology , Drosophila melanogaster/drug effects , Heterocyclic Compounds, 2-Ring/chemical synthesis , Heterocyclic Compounds, 2-Ring/toxicity , Indolizines/chemical synthesis , Indolizines/toxicity , Pesticides/chemical synthesis , Pesticides/toxicity , Plant Roots/parasitology , Structure-Activity Relationship , Sulfonamides/chemical synthesis , Sulfonamides/toxicity , Tylenchoidea/drug effects
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