ABSTRACT
In 15 patients suffering from Paget's disease, the serum levels of alkaline phosphatase (ALP), 25-hydroxycholecalciferol (25OHD3), 24,25-dihydroxycholecalciferol (24,25 [OH] 2D3), 1,25-dihydroxycholecalciferol (1,25 [OH] 2D3), and parathormone (PTH) as well as urinary excretion of hydroxyproline (HP) have been determined before and after three-month calcitonin therapy. Before therapy, high concentrations of serum ALP and urinary HP excretion had been observed, whereas serum levels of 24,25 (OH) 2D3 were below the lower limit of the normal range. Calcitonin therapy caused a 31% reduction in ALP and a 50% reduction in HP, as well as a significant increase in serum levels of 24,25 (OH) 2D3; the levels of 25OHD3, 1,25 (OH) 2D3, and PTH remained unchanged after treatment. The significant negative correlation between 24,25 (OH) 2D3 and ALP and HP before and after calcitonin therapy suggests that in Paget's disease there is an uncompensated increased bone usage of 24,25 (OH) 2D3.
Subject(s)
Calcitonin/therapeutic use , Osteitis Deformans/metabolism , Vitamin D/metabolism , 24,25-Dihydroxyvitamin D 3/blood , Adult , Aged , Alkaline Phosphatase/blood , Calcifediol/blood , Calcitriol/blood , Female , Humans , Hydroxyproline/urine , Male , Middle Aged , Osteitis Deformans/drug therapy , Parathyroid Hormone/blood , Time FactorsABSTRACT
A study was carried out on 180 recurrent kidney stone formers from the Campania region of southern Italy. The data showed that this hypercalciuric population was similar to that in previous studies; however, there was no difference in terms of parathyroid activity when compared with normal controls. The slightly depressed serum levels of vitamin D in hypercalciurics indicate that gut calcium absorption is not directly related to vitamin D levels. We found no difference in the prevalence of metabolic abnormalities associated with stone formation between the patients in this series and those in previous studies.
Subject(s)
Kidney Calculi/etiology , Acidosis, Renal Tubular/complications , Adolescent , Adult , Aged , Calcium/urine , Calcium, Dietary/metabolism , Child , Cyclic AMP/metabolism , Female , Humans , Hyperparathyroidism/complications , Italy , Kidney Calculi/diagnosis , Kidney Calculi/metabolism , Male , Middle Aged , Recurrence , Uric Acid/urine , Vitamin D/bloodABSTRACT
We have previously described a kindred with hereditary medullary thyroid carcinoma and pheochromocytoma (multiple endocrine neoplasia type 2A [MEN 2A]) with localized pruritic cutaneous manifestations present only in affected members. Although the initial skin biopsies reported did not show amyloidosis, subsequent skin biopsy results reported here have demonstrated amyloid which stained for keratin but not for calcitonin and established that this family represents an association of a rare autosomal dominant form of lichen amyloidosis with MEN 2A.
