1.
Arch Biochem Biophys
; 215(1): 222-9, 1982 Apr 15.
Article
in English
| MEDLINE
| ID: mdl-6284041
Subject(s)
Copper/pharmacology , Glycine/pharmacology , Organometallic Compounds , Superoxide Dismutase/metabolism , Animals , Copper Sulfate , Cytochrome c Group , Dianisidine/radiation effects , Free Radicals , Hydroxides , Hydroxyl Radical , Light , Nitroblue Tetrazolium/radiation effects , Oxidation-Reduction , Rats , Superoxides , Xanthine Oxidase
2.
Acta Physiol Pharmacol Bulg
; 6(1): 48-52, 1980.
Article
in English
| MEDLINE
| ID: mdl-6996423
ABSTRACT
It is established that the hexobarbital oxidase activity of 12,000 g rat liver supernatant does not change when examined at the 2nd h after whole body irradiation (700 R) but increases at longer postexposure periods (72 hours). Intraperitoneal injection of phenobarbital in daily doses of 80 mg/kg body wt for three days increases the hexobarbital oxidase activity of non-irradiated rats, the effect being much stronger in phenobarbital-treated rats at the 2nd h of postirradiation. The possible mechanisms of these effects are discussed, as well as their correlation with the increased lipid peroxidation and their significance for the radiation effect on the drug action.