Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 5 de 5
Filter
1.
Eur Radiol ; 24(10): 2540-51, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24898097

ABSTRACT

OBJECTIVE: The aim of this study was to evaluate the influence of different fat-suppression techniques on quantitative measurements and their reproducibility when applied to diffusion-weighted imaging (DWI) of breast lesions. METHODS: Twenty-five patients with different types of breast lesions were examined on a clinical 1.5-T magnetic resonance imaging (MRI) system. Two diffusion-weighted sequences with different fat-suppression methods were applied: one with spectral presaturation by inversion recovery (SPIR), and one with short-TI inversion recovery (STIR). The acquisition of both sequence variants was repeated with modified shim volume. Lesion-to-background contrast (LBC), apparent diffusion coefficients (ADC) ADC(0,1000) and ADC(50,1000), and their coefficients of variation (CV) were determined. RESULTS: In four patients, the image quality of DWI with SPIR was insufficient. In the other 21 patients, 46 regions of interest (ROI), including 11 malignant and 35 benign lesions, were analysed. The LBC, ADC(0,1000) and ADC(50,1000) values, which did not differ between initial and repeated measurements, were significantly higher for STIR than for SPIR. The mean CV improved from 10.8 % to 4.0 % (P = 0.0047) for LBC, from 6.3 % to 2.9 % (P = 0.0041) for ADC(0,1000), and from 6.3 % to 2.6 % (P = 0.0049) for ADC(50,1000). CONCLUSION: For STIR compared to SPIR fat suppression, improved lesion conspicuity, higher ADC values, and better measurement reproducibility were found in breast DWI. KEY POINTS: • Quality of fat suppression influences quantitative DWI breast lesion measurements. • In breast DWI, STIR fat suppression worked more reliably than SPIR. • Lesion-to-background contrast and its reproducibility were significantly higher with STIR fat suppression. • Lesional ADCs and their reproducibility were significantly higher with STIR fat suppression.


Subject(s)
Adipose Tissue/pathology , Breast Diseases/diagnosis , Breast/pathology , Diffusion Magnetic Resonance Imaging/methods , Adult , Aged , Biopsy, Large-Core Needle , Contrast Media , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Middle Aged , Prospective Studies , Reproducibility of Results
2.
Radiology ; 220(1): 31-9, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11425969

ABSTRACT

PURPOSE: To report our experience with magnetic resonance (MR) imaging-guided large-core breast biopsy of lesions visible at breast MR imaging only. MATERIALS AND METHODS: Stereotactic large-core (14-gauge) needle biopsy of 78 lesions visible at MR imaging only was performed with MR imaging guidance in 59 patients. Results were validated with excisional biopsy or mastectomy in 42 lesions and with radiologic-pathologic correlation and/or follow-up MR imaging for at least 2 years in another 17 lesions. The accuracy of MR imaging--guided core biopsy was determined for those 59 lesions with established validation. The effect on patient treatment was evaluated by comparing the prebiopsy treatment plan with the ultimate treatment. RESULTS: Histologic diagnosis from core biopsy was possible in 77 (99%) of 78 lesions. In the 59 lesions with established validation, the diagnostic accuracy of MR imaging--guided core biopsy was 98% (58 of 59). Successful MR imaging--guided core biopsy findings changed treatment in 70% (54 of 77) of lesions. Difficulties were due to the unsatisfactory performance of earlier types of MR imaging--compatible biopsy guns and decreasing target visibility during intervention. CONCLUSION: MR imaging--guided large-core stereotactic breast biopsy is sufficiently accurate for obtaining histologic proof of lesions visible only at MR imaging. It can change patient treatment by reducing unnecessary surgical biopsy and can enable one-step surgery for breast cancers.


Subject(s)
Breast Neoplasms/pathology , Magnetic Resonance Imaging/methods , Adult , Aged , Biopsy, Needle/methods , Cohort Studies , Female , Humans , Mammography/methods , Middle Aged , Prospective Studies , Reproducibility of Results , Sensitivity and Specificity , Severity of Illness Index
3.
AJR Am J Roentgenol ; 175(2): 391-7, 2000 Aug.
Article in English | MEDLINE | ID: mdl-10915681

ABSTRACT

OBJECTIVE: A T2-weighted turbo spin-echo sequence was compared with CT in immunocompromised patients with opportunistic pneumonia. SUBJECTS AND METHODS: Sixteen patients with pneumonia shown on helical CT were examined using MR imaging within 2 days. MR examinations were performed on a 1.5-T system with a transversal T2-weighted ultrashort turbo spin-echo sequence using expiratory gating and diastolic triggering. Two radiologists reviewed the MR and CT images independently. The number, localization, and morphology of lesions were noted. MR image quality was rated using a 4-point scale. RESULTS: The results of the CT and MR examinations concerning the number and morphology of pulmonary lesions caused by pneumonia were identical in 75% of the patients (n = 12). MR imaging was able to depict all typical features of pneumonia including different stages of parenchymal infiltration (ground-glass versus consolidation). MR imaging depicted early necrotizing pneumonia not shown on contrast-enhanced CT in 25% of the patients (n = 4); 82% of the MR examinations were rated as excellent (1 point) or good (2 points). CONCLUSION: T2-weighted turbo spin-echo imaging is able to depict characteristic features of pneumonia and shows excellent results compared with CT. This MR technique offers advantages in patients with pneumonia because of its higher sensitivity for necrotizing pneumonia.


Subject(s)
Immunocompromised Host , Magnetic Resonance Imaging , Pneumonia/diagnostic imaging , Pneumonia/pathology , Tomography, X-Ray Computed , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Necrosis , Prospective Studies , Tomography, X-Ray Computed/methods
4.
Radiology ; 215(1): 267-79, 2000 Apr.
Article in English | MEDLINE | ID: mdl-10751498

ABSTRACT

PURPOSE: To compare magnetic resonance (MR) imaging with conventional imaging in screening high-risk women. MATERIALS AND METHODS: This prospective trial included 192 asymptomatic and six symptomatic women who, on the basis of personal or family history or genetic analysis, were suspected or proved to carry a breast cancer susceptibility gene. RESULTS: Fifteen breast cancers were identified: nine in the 192 asymptomatic women (six in the first and three in the second screening round) and six in the symptomatic patients. Concerning the asymptomatic women, four of the nine breast cancers were detected and correctly classified with mammography and ultrasonography (US) combined; another two cancers were visible as well-circumscribed masses and were diagnosed as fibroadenomas. MR imaging allowed the correct classification and local staging of all nine cancers. In 105 asymptomatic women with validation of the 1st-year screening results, the sensitivities of mammography, US, and MR imaging were 33%, 33% (mammography and US combined, 44%), and 100%, respectively; the positive predictive values were 30%, 12%, and 64%, respectively. CONCLUSION: The accuracy of MR imaging is significantly higher than that of conventional imaging in screening high-risk women. Difficulties can be caused by an atypical manifestation of hereditary breast cancers at both conventional and MR imaging and by contrast material enhancement associated with hormonal stimulation.


Subject(s)
Breast Neoplasms/genetics , Breast/pathology , Genetic Predisposition to Disease , Heterozygote , Magnetic Resonance Imaging , Mass Screening , Adult , BRCA2 Protein , Bayes Theorem , Biopsy , Breast Neoplasms/classification , Breast Neoplasms/diagnosis , Breast Neoplasms/pathology , Cohort Studies , Female , Fibroadenoma/diagnosis , Follow-Up Studies , Genes, BRCA1/genetics , Genetic Markers/genetics , Humans , Mammography , Middle Aged , Neoplasm Proteins/genetics , Neoplasm Staging , Predictive Value of Tests , Prospective Studies , Reproducibility of Results , Risk Factors , Sensitivity and Specificity , Transcription Factors/genetics , Ultrasonography, Mammary
5.
Radiology ; 204(3): 667-75, 1997 Sep.
Article in English | MEDLINE | ID: mdl-9280242

ABSTRACT

PURPOSE: To evaluate the usefulness of preoperative magnetic resonance (MR) imaging-guided stereotactic localization and core biopsy of suspicious breast lesions that are visible at breast MR imaging alone (ie, that are clinically, mammographically, and ultrasonographically occult), with the goal of integrating this technique into the diagnostic and therapeutic work-up of MR-suspicious lesions in a clinical setting. MATERIALS AND METHODS: A stereotactic breast biopsy device was used for needle placement in and guide wire localization of 97 lesions in 66 patients or core biopsy of five lesions in five patients; all lesions were visible at MR imaging. Interventions were performed with MR guidance on a 0.5- or 1.5-T system. RESULTS: Lesion localization and resection were successful in 95 of the 97 lesions; two of the lesions were not resected in spite of correct guide wire localization. In this series, 53 (55%) of 97 lesions proved malignant (11 [21%] in situ; 42 [79%] invasive). Lesions were 4-19 mm (mean, 8.7 mm); all invasive cancers corresponded to a pT1 tumor stage. Location of the lesion in the parenchyma (retroareolar or prepectoral) did not interfere with accessibility. CONCLUSION: MR imaging-guided stereotactic hook-wire placement and excisional biopsy are accurate and effective in managing lesions identified at only breast MR imaging. MR imaging-guided core biopsy holds promise for allowing a definite work-up of these lesions.


Subject(s)
Biopsy, Needle/instrumentation , Breast Neoplasms/diagnosis , Breast/pathology , Magnetic Resonance Imaging , Stereotaxic Techniques/instrumentation , Adult , Aged , Biopsy, Needle/methods , Breast Neoplasms/surgery , Female , Humans , Middle Aged
SELECTION OF CITATIONS
SEARCH DETAIL
...