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Sequence variation analysis of the prolactin receptor C-terminal region in women with premature ovarian failure.
Bachelot, Anne; Bouilly, Justine; Liu, Yuchen; Rebourcet, Diane; Leux, Céline; Kuttenn, Frédérique; Touraine, Philippe; Binart, Nadine.
Fertil Steril ; 94(7): 2772-5, 2010 Dec.
Article in English | MEDLINE | ID: mdl-20655519

ABSTRACT

Using a mouse model expressing only the PRL receptor short isoform mimicking premature ovarian failure, signaling pathways induced by PRL were analyzed in mouse ovaries. Sequencing of the coding portion of exons 10 and 11, specific to the long and short receptor isoform, respectively, did not revealed any mutation in 101 women with premature ovarian failure.


Subject(s)
Primary Ovarian Insufficiency/genetics , Receptors, Prolactin/genetics , Adult , Animals , Base Sequence , Cell Count , DNA Mutational Analysis , Female , Genetic Variation , Humans , Male , Mice , Mice, Transgenic , Oocytes/cytology , Oocytes/pathology , Primary Ovarian Insufficiency/pathology , Protein Isoforms/chemistry , Protein Isoforms/genetics , Protein Structure, Tertiary/genetics , Receptors, Prolactin/chemistry
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