ABSTRACT
Hypophysitis is the inflammation of the pituitary gland with varying effects on hormone function that may be present secondary to the use of certain medications, infections, systemic inflammatory disorders, and other etiologies. Immunotherapy-related hypophysitis is a rare phenomenon. However, it representsâ¯an indicationâ¯of treatment interruption.â¯We report a 60-year-old female with renal clear cell carcinoma onâ¯Nivolumab and Ipilimumabâ¯(NIVO/IPI) intravenously (IV). After the second cycle of therapy, the patient reported a fall, with associatedâ¯lightheadedness, dizziness, nausea, vomiting, and hotâ¯flashes. The patient's symptoms and history were concerning for hypophysitis, so early treatment and cessation of the checkpoint inhibitors led to the patient's clinical improvement.