Subject(s)
Bone Neoplasms/drug therapy , Lymphoma, Large B-Cell, Diffuse/drug therapy , Penile Neoplasms/drug therapy , Prostatic Neoplasms/drug therapy , Vascular Neoplasms/drug therapy , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Neoplasms/pathology , Humans , Lymphoma, Large B-Cell, Diffuse/diagnosis , Lymphoma, Large B-Cell, Diffuse/pathology , Male , Penile Neoplasms/pathology , Prostatic Neoplasms/pathology , Recurrence , Vascular Neoplasms/pathologyABSTRACT
Detection of PTLD uses PCR to detect circulating EBV DNA in the blood or in situ hybridization to identify EBV DNA in tissue biopsies. EBV DNA was detected in the tissue section using both real-time PCR and in situ hybridization. We report an unusual presentation of PTLD with no detectable EBV DNA in the blood using EBER-1 and EBNA-1 PCR assays. This report suggests that the use of EBV-PCR for the early detection of PTLD in blood samples may not be 100% effective in detecting disease.
Subject(s)
DNA, Viral/analysis , Herpesvirus 4, Human/genetics , Liver Transplantation/immunology , Lymphoproliferative Disorders/metabolism , Child , Female , Graft Rejection/drug therapy , Humans , Immunoglobulins, Intravenous/administration & dosage , Lymphocytes/pathology , Lymphoproliferative Disorders/blood , Methylprednisolone/administration & dosage , Polymerase Chain Reaction , Viral LoadABSTRACT
Panfolliculoma is a rare follicular neoplasm with differentiation toward both upper (infundibulum and isthmus) and lower (stem, hair matrix, and bulb) segments of a hair follicle. We present an unusual case of cystic panfolliculoma. A 33-year-old Hispanic woman presented with an 8-month history of a 3.0-cm cystic scalp mass. The lesion was excised, and the histologic sections showed a cystic follicular neoplasm that contained corneocytes in basket-woven and laminated array, trichohyalin granules of the inner root sheath, germinative cells, papillae, matrical cells, and "shadow" cells. Cytokeratin 903 and cytokeratin 5/6 immunostains uniformly highlight the tumor cells. Ber-EP4 strongly labels the germinative cells but not the follicular papillae. CD34 labels the surrounding fibrotic stroma and focally the epithelial component.
