Everlasting impact of initial perturbations on first-passage times of non-Markovian random walks.

Persistence, defined as the probability that a signal has not reached a threshold up to a given observation time, plays a crucial role in the theory of random processes. Often, persistence decays algebraically with time with non trivial exponents. However, general analytical methods to calculate persistence exponents cannot be applied to the ubiquitous case of non-Markovian systems relaxing transiently after an imposed initial perturbation. Here, we introduce a theoretical framework that enables the non-perturbative determination of persistence exponents of Gaussian non-Markovian processes with non stationary dynamics relaxing to a steady state after an initial perturbation. Two situations are analyzed: either the system is subjected to a temperature quench at initial time, or its past trajectory is assumed to have been observed and thus known. Our theory covers the case of spatial dimension higher than one, opening the way to characterize non-trivial reaction kinetics for complex systems with non-equilibrium initial conditions.

Survival probability of stochastic processes beyond persistence exponents.

For many stochastic processes, the probability [Formula: see text] of not-having reached a target in unbounded space up to time [Formula: see text] follows a slow algebraic decay at long times, [Formula: see text]. This is typically the case of symmetric compact (i.e. recurrent) random walks. While the persistence exponent [Formula: see text] has been studied at length, the prefactor [Formula: see text], which is quantitatively essential, remains poorly characterized, especially for non-Markovian processes. Here we derive explicit expressions for [Formula: see text] for a compact random walk in unbounded space by establishing an analytic relation with the mean first-passage time of the same random walk in a large confining volume. Our analytical results for [Formula: see text] are in good agreement with numerical simulations, even for strongly correlated processes such as Fractional Brownian Motion, and thus provide a refined understanding of the statistics of longest first-passage events in unbounded space.

Universal first-passage statistics in aging media.

It has been known for a long time that the kinetics of diffusion-limited reactions can be quantified by the time needed for a diffusing molecule to reach a target: the first-passage time (FPT). So far the general determination of the mean first-passage time to a target in confinement has left aside aging media, such as glassy materials, cellular media, or cold atoms in optical lattices. Here we consider general non-Markovian scale-invariant diffusion processes, which model a broad class of transport processes of molecules in aging media, and demonstrate that all the moments of the FPT obey universal scalings with the confining volume with nontrivial exponents. Our analysis shows that a nonlinear scaling with the volume of the mean FPT, which quantities the mean reaction time, is the hallmark of aging and provides a general tool to quantify its impact on reaction kinetics in confinement.

Mean first-passage times of non-Markovian random walkers in confinement.

The first-passage time, defined as the time a random walker takes to reach a target point in a confining domain, is a key quantity in the theory of stochastic processes. Its importance comes from its crucial role in quantifying the efficiency of processes as varied as diffusion-limited reactions, target search processes or the spread of diseases. Most methods of determining the properties of first-passage time in confined domains have been limited to Markovian (memoryless) processes. However, as soon as the random walker interacts with its environment, memory effects cannot be neglected: that is, the future motion of the random walker does not depend only on its current position, but also on its past trajectory. Examples of non-Markovian dynamics include single-file diffusion in narrow channels, or the motion of a tracer particle either attached to a polymeric chain or diffusing in simple or complex fluids such as nematics, dense soft colloids or viscoelastic solutions. Here we introduce an analytical approach to calculate, in the limit of a large confining volume, the mean first-passage time of a Gaussian non-Markovian random walker to a target. The non-Markovian features of the dynamics are encompassed by determining the statistical properties of the fictitious trajectory that the random walker would follow after the first-passage event takes place, which are shown to govern the first-passage time kinetics. This analysis is applicable to a broad range of stochastic processes, which may be correlated at long times. Our theoretical predictions are confirmed by numerical simulations for several examples of non-Markovian processes, including the case of fractional Brownian motion in one and higher dimensions. These results reveal, on the basis of Gaussian processes, the importance of memory effects in first-passage statistics of non-Markovian random walkers in confinement.

Non-Markovian closure kinetics of flexible polymers with hydrodynamic interactions.

This paper presents a theoretical analysis of the closure kinetics of a polymer with hydrodynamic interactions. This analysis, which takes into account the non-Markovian dynamics of the end-to-end vector and relies on the preaveraging of the mobility tensor (Zimm dynamics), is shown to reproduce very accurately the results of numerical simulations of the complete nonlinear dynamics. It is found that Markovian treatments based on a Wilemski-Fixman approximation significantly overestimate cyclization times (up to a factor 2), showing the importance of memory effects in the dynamics. In addition, this analysis provides scaling laws of the mean first cyclization time (MFCT) with the polymer size N and capture radius b, which are identical in both Markovian and non-Markovian approaches. In particular, it is found that the scaling of the MFCT for large N is given by T ∼ N(3/2)ln(N/b(2)), which differs from the case of the Rouse dynamics where T ∼ N(2). The extension to the case of the reaction kinetics of a monomer of a Zimm polymer with an external target in a confined volume is also presented.