ABSTRACT
Systemic lupus erythematosus (SLE) is a complex multiorgan autoimmune disease with varied clinical and laboratory manifestations. Although common in lupus disease, liver test disturbance is rarely seen as a primary manifestation at diagnosis. In this case report, we describe acute hepatitis as the initial presentation of SLE in a young woman.
Le lupus érythémateux systémique (LES) est une maladie autoimmune multiorganique complexe aux manifestations cliniques et biologiques variées. Bien que fréquente au cours de la maladie lupique, une perturbation des tests hépatiques est rarement observée comme manifestation principale au moment du diagnostic. Dans ce cas clinique, nous décrivons une hépatite aiguë comme présentation initiale d'un LES chez une jeune femme.
Subject(s)
Autoimmune Diseases , Hepatitis , Lupus Erythematosus, Systemic , Female , Humans , Hepatitis/diagnosis , Hepatitis/etiology , Acute Disease , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/diagnosis , LaboratoriesABSTRACT
Acute coronary syndrome (ACS) is the leading cause of death among women in high-income countries. However, the literature is mainly based on the male model as are the resulting scientific guidelines. female-specific risk factors are frequent and still underestimated, contributing to a difference in overall management. This article highlights the gender differences in acute coronary heart disease.
Le syndrome coronarien aigu (SCA) constitue la première cause de mortalité chez la femme dans les pays à revenus élevés. Toutefois, la littérature est essentiellement basée sur le modèle masculin, de même que les recommandations scientifiques qui en découlent. Les facteurs de risque liés au sexe féminin sont fréquents et encore sous-estimés, contribuant à une différence dans la prise en charge globale. Cet article met en évidence les différences intersexes lors d'une maladie coronarienne aiguë.
Subject(s)
Acute Coronary Syndrome , Coronary Disease , Acute Coronary Syndrome/diagnosis , Acute Coronary Syndrome/epidemiology , Acute Coronary Syndrome/therapy , Acute Disease , Coronary Disease/epidemiology , Coronary Disease/therapy , Female , Humans , Male , Risk Factors , Sex FactorsABSTRACT
Option recommended by World Health Organization (WHO) includes human papillomavirus (HPV) primary screening followed by visual inspection with acetic acid (VIA) triage. We implemented a program based on a 3T-approach (Test-Triage and Treat). Our objective was to verify the effectiveness of the program by defining a set of performance indices. A sensitization campaign was performed in Dschang (Cameroon) and women aged 30-49 years were invited to participate for screening based on the 3T-approach. Participants performed HPV self-sampling (Self-HPV), analyzed with the point-of-care Xpert HPV assay followed by VIA/VILI triage and treatment if required. Key performance indicators (KPIs) for screening, diagnosis, treatment and follow-up were defined, and achievable targets were described for which the approach is likely to be running optimally. A total of 840 women with a mean age of 39.4±5.9 years participated. The KPIs included (i) the screening rate (8.4% at 7 months, target =20% at 12 months), (ii) HPV positivity rate (19.8%, expected range 18-25%), (iii) compliance to referral to VIA/VILI and complete test (100%, target >90%), (iv) compliance to referral to thermal ablation (100%, target >90%), (v) VIA/VILI positivity rate (50.6%, expected range 45-55%), (vi) a single visit from diagnostic to treatment (79.8%, target >80%), (vii) compliance to follow-up at 1 month (96.4%, target >80%) and (viii) at 6 months (70.6%, target >80%). Program performance based on the single-visit 3T-approach corresponded to defined targets and preliminary results support adequateness of KPIs for periodic monitoring.