W-SBA-15 as an Effective Catalyst for the Epoxidation of 1,5,9-Cyclododecatriene.

The results of a study on the epoxidation of 1,5,9-cyclododecatriene (CDT) on a W-SBA-15 catalyst using the batch and half-periodic methods are presented. During this study, the activity of the W-SBA-15 catalyst was compared to that of the Ti-SBA-15 catalyst, and the W-SBA-15 catalyst was found to be about 20 times more active than the Ti-SBA-15 catalyst. The highest CDT conversion so far, amounting to 86 mol%, was obtained after carrying out the 4 h epoxidation process. Conducting the studied process using the semi-batch method did not result in the significant improvement in value functions describing this process (CDT conversion and selectivity of CDT transformation to ECDD), but the fastest H2O2 dosing rate (246 µL/h) allowed us to obtain 9 mol% higher CDT conversion in comparison to the batch method.

The analgesic and anti-inflammatory effect of new oleanolic acid acyloxyimino derivative.

The new derivative of well-known triterpene, oleanolic acid: methyl 3-octanoyloxyiminoolean-12-en-28-oate 5, was synthesized by the action of caprylic acid on methyl oleanolate 3-oxime in the presence of dicyclohexylcarbodiimide in dioxane. The molecular structure of the obtained product 5 was confirmed by spectral methods. The acute toxicity, locomotor activity, and the dose-dependent analgesic activity were studied. In addition, the effect of compound 5 on morphine-induced analgesic activity, the dose-dependent anti-inflammatory activity and the effect of the compound on diclofenac anti-inflammatory activity study were performed. The results proved a low toxicity (LD50 > 2 g/kg) of the tested product 5, which affected neither vertical nor horizontal locomotor activity in the given range of doses. The triterpene 5 also produced centrally mediated (morphine-like) analgesic action; however, only in the highest dose. The synergistic analgesic activity of 5 and morphine in the doses of 30.0 and 300.0mg/kg was found. Compound 5 expressed the anti-inflammatory action which did not affect the anti-inflammatory activity of diclofenac after their combined administration.

Reactions of N(3) -substituted amidrazones with cis-1,2-cyclohexanedicarboxylic anhydride and biological activities of the products.

A series of novel compounds were synthesized in reactions of N(3) -substituted amidrazones with cis-1,2-cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H(1) NMR and IR spectrometry as well as elemental analysis. Potential biological effects of new compounds were predicted with the Prediction of Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, and anti-inflammatory activities were experimentally verified.

Special applications of fluorinated organic compounds.

The applications of fluorinated organic compounds (FOCs) as finishing agent for fabrics, components of extinguishing agents, electroplating bathes, lubricating oils, oxygen carriers in blood substitutes have been discussed. Recent achievements in methods of the fluorination and general principles of the synthesis of useful perfluorinated organic compounds are given as well.

The influence of the solvent on the epoxidation of cis,trans,trans-1,5,9-cyclododecatriene to trans-1,2-epoxy-cis,trans-5,9-cyclododecadiene by catalytic system tert-butyl hydroperoxide/Mo(CO)6.

The epoxidation of cis,trans,trans-1,5,9-cyclododecatriene to trans-1,2-epoxy- cis,trans-5,9-cyclododecadiene with the use of commercial solution of tert-butyl hydroperoxide in various organic solvents: tert-butyl peroxide, isooctane, decane, and nonane was investigated. The process was investigated in different experimental conditions. The best results were achieved with the application of tert-butyl hydroperoxide in isooctane. A significant influence of the nature of the solvent on the results of trans-1,2-epoxy-cis,trans-5,9-cyclododecadiene synthesis was found.

Thermal decomposition of methylene-4,4'-di(ethylphenyl-carbamate) to methylene-4,4'-di(phenylisocyanate).

During thermal decomposition of methylene-4,4'-di(ethylphenylcarbamate) (MDU), methylene-4,4'-di(phenylisocyanate) (MDI) appears to be the main product, provided that the ethanol formed in the reaction is carried away. Polycarbodiimides are the main by-products along with small amounts of 4,4'-di(aminophenyl)methane and its derivatives. Under the reaction conditions used in these studies, the latter compound together with its derivatives, reacts both with MDI and MDU. At 220-310 degrees C and a reaction time of 80-110 min, the selectivity of the MDU transformation to MDI in relation to consumed MDU is 60-87 mol.%. The selectivity of the transformation to polycarbodiimides is 7-20 mol.%, and that to amines and urea derivatives is about 1-2 mol.%.

Technological parameters of the ammonolysis of waste 1,2-dichloropropane.

The ammonolysis of waste 1,2-dichloropropane (DCP) using liquid ammonia has been investigated. The influence of temperature, molar ratio of NH3/1,2-dichloropropane and reaction time was examined. The highest yield of the synthesis was achieved at a temperature of 140 degrees C, for the reaction time of 3 h and the molar ratio of NH3/1,2-dichloropropane as 20:1. Under these conditions the degree of 1,2-dichloropropane conversion amounted to 97.1 mol% and the selectivity of transformation to 1,2-diaminopropane (DAP) in relation to consumed 1,2-dichloropropane was 25.3 mol%, whereas in relation to consumed ammonia 17.9 mol%. The remaining 1,2-dichloropropane reacts to form polypropyleneamines.