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Virology ; 429(2): 163-70, 2012 Aug 01.
Article in English | MEDLINE | ID: mdl-22579352

ABSTRACT

DNAM-1 gene-deficient (-/-) mice take significantly longer to clear an acute and persistent LCMV infection in vivo than DNAM-1 +/+ mice. During acute LCMV priming, at the single cell level, DNAM-1 -/- mice made significantly less cytoplasmic CD8 TNF-α and IL-2 but not IFN-γ than their DNAM-1 +/+ counterparts. Restimulated immune memory CD8 T cells from DNAM-1 -/- and DNAM-1 +/+ mice were equivalent in cytolytic activity against LCMV-infected target cells but DNAM-1 -/- CD8 T cells had significant reductions in TNF-α and IL-2 that were associated on adoptive transfer with the inability to terminate the persistent viral infection.


Subject(s)
Antigens, Differentiation, T-Lymphocyte/genetics , Arenaviridae Infections/immunology , CD8-Positive T-Lymphocytes/immunology , Interleukin-2/immunology , Lymphocytic choriomeningitis virus/immunology , Tumor Necrosis Factor-alpha/immunology , Adoptive Transfer , Animals , Disease Models, Animal , Male , Mice , Mice, Inbred C57BL , Mice, Knockout
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