ABSTRACT
We studied the incidence of testicular feminization syndrome in Denmark over a 7-year period and found it to be about 1:20,400. Twenty-one patients are described in greater detail. Four patients had gonadal tumors, none of these being malignant. Ten patients (47.6%) had inguinal hernias in early childhood. All patients but one were gonadectomized. Eleven patients (52.4%) disclosed signs of partial androgen function. Only 5 of them had their gonads removed immediately.
Subject(s)
Androgen-Insensitivity Syndrome/complications , Genital Neoplasms, Male/complications , Adolescent , Aged , Androgen-Insensitivity Syndrome/epidemiology , Androgen-Insensitivity Syndrome/surgery , Child, Preschool , Denmark/epidemiology , Humans , Incidence , Infant , Infant, Newborn , Male , Middle AgedABSTRACT
A randomized, double blind, cross-over study was carried out on long-term gerontopsychiatric patients. The aim of the study was to compare the EEG effects of a four weeks' treatment with 10-methoxy-1,6-dimethyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline, Sermion) with those of dihydroergotoxin-mesylate (DHETM) and a four weeks' placebo period. The results of the power spectrum analysis with a consecutive factor analysis of the spectral data show that nicergoline and DHETM have a vigilance stabilizing effect which is characterized by a decrease in the relative power of slow delta-theta frequencies and an increase in the alpha power. As opposed to DHETM, for which this effect could not be proved, nicergoline produces a significant increase in power of the fast alpha frequencies as well as of the beta 1, beta 2, and beta 3 band.
Subject(s)
Attention/drug effects , Electroencephalography , Ergolines/pharmacology , Nicergoline/pharmacology , Aged , Dihydroergotoxine/pharmacology , Double-Blind Method , Humans , Male , Middle AgedABSTRACT
The electroencephalographic and clinical effects of piracetam were studied in a group of 11 hospitalized gerontopsychiatric patients treated with a daily dosage of 4.8 g for 8--13 months. The EEG was evaluated by power spectral analysis, followed by a principal component analysis of frequency parameters. The statistical analysis of the resulting factor scores shows that piracetam induces significant EEG changes: decrease of slow frequencies, augmentation and acceleration of alpha-activity and increase of beta-activity. These EEG changes, indicating an increase in vigilance, correspond clinically to an improvement of communicative behavior and cognitive functioning.
Subject(s)
Arousal/drug effects , Electroencephalography , Piracetam/pharmacology , Pyrrolidinones/pharmacology , Aged , Clinical Trials as Topic , Cognition/drug effects , Communication , Humans , Middle Aged , Piracetam/therapeutic use , Placebos , Social BehaviorABSTRACT
Ten healthy volunteers received a single oral dose of 100 mg nomifensive, a new antidepressant (tetragtdriusiqyubikube deruvatuve; Hoe 36-984). The drug-induced effects on the EEG were compared with those of placebo. The statistically proved results show that nomifensine causes a distinct shift in vigilance with two different partial processes. After an initially occurring stabilization of the dominant alpha-frequency there appears a polyrhythmic disintegration of the alpha-rhythm with increase of slower and faster frequencies. At the same time a shifting takes place within the beta-range with increasing of 23.5-32.0 Hz-components. Accordingly it is evident that nomifensine results in a typical pharmaco-electroencephalographic profile.
