ABSTRACT
Risk assessment of environmental pollutants is concerned with the identification of compounds in the environment that might be hazardous to human health: measuring exposure levels, measuring cellular damage and then estimating the probability of harm occurring. The feasibility of such a comprehensive approach has been explored in this study of two groups of workers, one of which may be occupationally exposed to exhaust fumes. No statistically significant difference in cellular damage, as measured by the lymphocyte micronucleus assay, was found between these two groups of workers, although clear differences in exposure levels to volatile organic compounds were detected. A number of other factors identified in the study did show clear effects on micronucleus frequency.
Subject(s)
Environmental Monitoring/methods , Micronucleus Tests , Occupational Exposure , Vehicle Emissions/toxicity , Adult , Age Factors , Alcohol Drinking , Benzene/toxicity , Carboxyhemoglobin/analysis , Health Status , Humans , Lead/blood , Lymphocytes/drug effects , Male , Middle Aged , Smoking , Vehicle Emissions/analysis , X-Rays/adverse effectsABSTRACT
Whether or not to treat bacteriuria (greater than or equal to 100,000 col/cc) in the asymptomatic patient has long been controversial. Fifty-two patients with uncomplicated neurogenic bladder disease secondary to spinal cord injury and bacteriuria were followed throughout their hospitalization. Antibiotics were reserved only for symptomatic patients. Our results indicate the value of no treatment for chronic bacteriuria as an alternative to chronic suppressive therapy.
Subject(s)
Bacteriuria/complications , Spinal Cord Injuries/complications , Urinary Bladder, Neurogenic/etiology , Adolescent , Adult , Aged , Anti-Infective Agents, Urinary/therapeutic use , Bacteriuria/therapy , Escherichia coli/isolation & purification , Female , Humans , Klebsiella/isolation & purification , Male , Middle Aged , Pseudomonas/isolation & purification , Streptococcus/isolation & purification , Urinary Bladder, Neurogenic/therapy , Urinary CatheterizationABSTRACT
Urinary incontinence in female subjects with bladder instability secondary to neurogenic bladder disease is difficult to manage. Many times pharmacologic manipulation and the standard anti-incontinence surgical procedures are unsuccessful. We have found that the urethral occlusive technique using polytetrafluoroethylene (Teflon) paste is highly effective in maintaining continence. We describe 6 patients who achieved complete urinary control and empty the bladder with the use of intermittent catheterization. All of the patients are extremely satisfied with the end results of urinary continence and have accepted self-catheterization well.
Subject(s)
Polytetrafluoroethylene/administration & dosage , Urinary Bladder, Neurogenic/complications , Urinary Incontinence/therapy , Adult , Child , Female , Humans , Injections , Male , Middle Aged , Radiography , Urethra , Urinary Bladder, Neurogenic/diagnostic imaging , Urinary Incontinence/diagnostic imaging , Urinary Incontinence/etiologyABSTRACT
We are reporting on a 23 year old white male with neurogenic bladder disease secondary to spinal cord injury, who recently was discovered as having a primary transitional cell carcinoma of the posterior urethra. He is the youngest patient with neurologic involvement of the lower urinary tract presenting a malignant urethral tumor.
