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2.
Breastfeed Med ; 11: 203-6, 2016 05.
Article in English | MEDLINE | ID: mdl-27032034

ABSTRACT

BACKGROUND: Studies have not found that hormonal contraceptive implants adversely affect breastfeeding, but theoretical concerns exist. METHODS: We reported a case of reduced weight gain in an exclusively breastfed infant in association with placement of (ENG)-releasing contraceptive implant (Nexplanon) to the FDA Adverse Events Reporting System (FAERS). We further queried reports to FAERS and reviewed published studies of the ENG implant during breastfeeding. RESULTS: A breastfeeding mother received an ENG implant at 4 weeks postpartum. Her infant was exclusively breastfeeding. One month after implant placement, the infant had lost 145 g, dropping from the 44th percentile to the 6th percentile for growth. During this period, the mother had not returned to work or decreased frequency of feeding. During a 2-year period of FAERS reports, we found one other report of reduced milk supply following ENG implant placement. Among 108 breastfeeding women studied while using the ENG implant, there was one case of lactation failure. If this were not due to chance, the estimated risk of lactation failure with the ENG implant would be 0.9% (95% confidence interval 0.2-5.1%). CONCLUSION: Given uncertainty regarding the true effect of ENG implants on lactation, it seems prudent for providers to counsel each woman about a possible effect on milk supply so that she can monitor her infant for signs of impaired milk transfer. Patient-centered counseling approaches are needed that allow each woman to assess her own individual tolerance of risk of unplanned pregnancy versus possible risk of lactation failure.


Subject(s)
Contraceptive Agents, Female/adverse effects , Desogestrel/adverse effects , Lactation/drug effects , Milk, Human/drug effects , Mothers , Weight Gain/drug effects , Adult , Breast Feeding , Contraceptive Agents, Female/administration & dosage , Desogestrel/administration & dosage , Directive Counseling , Drug Implants , Female , Humans , Infant , Infant, Newborn , Male , Milk, Human/metabolism , North Carolina , Patient Education as Topic , Postpartum Period , Pregnancy
3.
J Abnorm Psychol ; 118(3): 634-646, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19685959

ABSTRACT

The interpersonal-psychological theory of suicidal behavior (T. E. Joiner, 2005) makes 2 overarching predictions: (a) that perceptions of burdening others and of social alienation combine to instill the desire for death and (b) that individuals will not act on the desire for death unless they have developed the capability to do so. This capability develops through exposure and thus habituation to painful and/or fearsome experiences and is posited by the theory to be necessary for overcoming powerful self-preservation pressures. Two studies tested these predictions. In Study 1, the interaction of (low) family social support (cf. social alienation or low belonging) and feeling that one does not matter (cf. perceived burdensomeness) predicted current suicidal ideation, beyond depression indices. In Study 2, the 3-way interaction among a measure of low belonging, a measure of perceived burdensomeness, and lifetime number of suicide attempts (viewed as a strong predictor of the level of acquired capability for suicide) predicted current suicide attempt (vs. ideation) among a clinical sample of suicidal young adults, again beyond depression indices and other key covariates. Implications for the understanding, treatment, and prevention of suicidal behavior are discussed.


Subject(s)
Interpersonal Relations , Psychological Theory , Social Alienation , Social Identification , Social Support , Suicide, Attempted/psychology , Antidepressive Agents/therapeutic use , Attitude to Death , Comorbidity , Female , Humans , Male , Mental Disorders/diagnosis , Mental Disorders/psychology , Motivation , Patient Admission , Personality Inventory/statistics & numerical data , Problem Solving , Psychometrics , Psychotherapy , Risk Factors , Suicide, Attempted/prevention & control , Young Adult
4.
JAMA ; 298(19): 2296-304, 2007 Nov 21.
Article in English | MEDLINE | ID: mdl-18029834

ABSTRACT

CONTEXT: Without detailed evidence of their effectiveness, pedometers have recently become popular as a tool for motivating physical activity. OBJECTIVE: To evaluate the association of pedometer use with physical activity and health outcomes among outpatient adults. DATA SOURCES: English-language articles from MEDLINE, EMBASE, Sport Discus, PsychINFO, Cochrane Library, Thompson Scientific (formerly known as Thompson ISI), and ERIC (1966-2007); bibliographies of retrieved articles; and conference proceedings. STUDY SELECTION: Studies were eligible for inclusion if they reported an assessment of pedometer use among adult outpatients, reported a change in steps per day, and included more than 5 participants. DATA EXTRACTION AND DATA SYNTHESIS: Two investigators independently abstracted data about the intervention; participants; number of steps per day; and presence or absence of obesity, diabetes, hypertension, or hyperlipidemia. Data were pooled using random-effects calculations, and meta-regression was performed. RESULTS: Our searches identified 2246 citations; 26 studies with a total of 2767 participants met inclusion criteria (8 randomized controlled trials [RCTs] and 18 observational studies). The participants' mean (SD) age was 49 (9) years and 85% were women. The mean intervention duration was 18 weeks. In the RCTs, pedometer users significantly increased their physical activity by 2491 steps per day more than control participants (95% confidence interval [CI], 1098-3885 steps per day, P < .001). Among the observational studies, pedometer users significantly increased their physical activity by 2183 steps per day over baseline (95% CI, 1571-2796 steps per day, P < .0001). Overall, pedometer users increased their physical activity by 26.9% over baseline. An important predictor of increased physical activity was having a step goal such as 10,000 steps per day (P = .001). When data from all studies were combined, pedometer users significantly decreased their body mass index by 0.38 (95% CI, 0.05-0.72; P = .03). This decrease was associated with older age (P = .001) and having a step goal (P = .04). Intervention participants significantly decreased their systolic blood pressure by 3.8 mm Hg (95% CI, 1.7-5.9 mm Hg, P < .001). This decrease was associated with greater baseline systolic blood pressure (P = .009) and change in steps per day (P = .08). CONCLUSIONS: The results suggest that the use of a pedometer is associated with significant increases in physical activity and significant decreases in body mass index and blood pressure. Whether these changes are durable over the long term is undetermined.


Subject(s)
Biomechanical Phenomena/instrumentation , Health Promotion/methods , Walking , Blood Glucose , Blood Pressure , Body Mass Index , Exercise , Humans , Insulin/blood , Lipids/blood , Walking/physiology
5.
Arch Pediatr Adolesc Med ; 161(9): 896-905, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17768291

ABSTRACT

OBJECTIVE: To systematically review all published case reports of children with anthrax to evaluate the predictors of disease progression and mortality. DATA SOURCES: Fourteen selected journal indexes (1900-1966), MEDLINE (1966-2005), and the bibliographies of all retrieved articles. STUDY SELECTION: Case reports (any language) of anthrax in persons younger than 18 years published between January 1, 1900, and December 31, 2005. Main Exposures Cases with symptoms and culture or Gram stain or autopsy evidence of anthrax infection. MAIN OUTCOME MEASURES: Disease progression, treatment responses, and mortality. RESULTS: Of 2499 potentially relevant articles, 73 case reports of pediatric anthrax (5 inhalational cases, 22 gastrointestinal cases, 37 cutaneous cases, 6 cases of primary meningoencephalitis, and 3 atypical cases) met the inclusion criteria. Only 10% of the patients were younger than 2 years, and 24% were girls. Of the few children with inhalational anthrax, none had nonheadache neurologic symptoms, a key finding that distinguishes adult inhalational anthrax from more common illnesses, such as influenza. Overall, observed mortality was 60% (3 of 5) for inhalational anthrax, 65% (13 of 20) for gastrointestinal anthrax, 14% (5 of 37) for cutaneous anthrax, and 100% (6 of 6) for primary meningoencephalitis. Nineteen of the 30 children (63%) who received penicillin-based antibiotics survived, and 9 of the 11 children (82%) who received anthrax antiserum survived. CONCLUSIONS: The clinical presentation of children with anthrax is varied. The mortality rate is high in children with inhalational anthrax, gastrointestinal anthrax, and anthrax meningoencephalitis. Rapid diagnosis and effective treatment of anthrax in children requires recognition of the broad spectrum of clinical presentations of pediatric anthrax.


Subject(s)
Anthrax/epidemiology , Gastrointestinal Diseases/epidemiology , Lung Diseases/epidemiology , Skin Diseases, Bacterial/epidemiology , Adolescent , Anthrax/drug therapy , Anthrax/mortality , Child , Child, Preschool , Disease Progression , Female , Gastrointestinal Diseases/drug therapy , Gastrointestinal Diseases/microbiology , Gastrointestinal Diseases/mortality , Global Health , Humans , Infant , Lung Diseases/drug therapy , Lung Diseases/microbiology , Lung Diseases/mortality , Male , Skin Diseases, Bacterial/drug therapy , Skin Diseases, Bacterial/mortality , Survival Analysis
6.
Med Care ; 44(7): 646-57, 2006 Jul.
Article in English | MEDLINE | ID: mdl-16799359

ABSTRACT

BACKGROUND: Care remains suboptimal for many patients with hypertension. PURPOSE: The purpose of this study was to assess the effectiveness of quality improvement (QI) strategies in lowering blood pressure. DATA SOURCES: MEDLINE, Cochrane databases, and article bibliographies were searched for this study. STUDY SELECTION: Trials, controlled before-after studies, and interrupted time series evaluating QI interventions targeting hypertension control and reporting blood pressure outcomes were studied. DATA EXTRACTION: Two reviewers abstracted data and classified QI strategies into categories: provider education, provider reminders, facilitated relay of clinical information, patient education, self-management, patient reminders, audit and feedback, team change, or financial incentives were extracted. DATA SYNTHESIS: Forty-four articles reporting 57 comparisons underwent quantitative analysis. Patients in the intervention groups experienced median reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) that were 4.5 mm Hg (interquartile range [IQR]: 1.5 to 11.0) and 2.1 mm Hg (IQR: -0.2 to 5.0) greater than observed for control patients. Median increases in the percentage of individuals achieving target goals for SBP and DBP were 16.2% (IQR: 10.3 to 32.2) and 6.0% (IQR: 1.5 to 17.5). Interventions that included team change as a QI strategy were associated with the largest reductions in blood pressure outcomes. All team change studies included assignment of some responsibilities to a health professional other than the patient's physician. LIMITATIONS: Not all QI strategies have been assessed equally, which limits the power to compare differences in effects between strategies. CONCLUSION: QI strategies are associated with improved hypertension control. A focus on hypertension by someone in addition to the patient's physician was associated with substantial improvement. Future research should examine the contributions of individual QI strategies and their relative costs.


Subject(s)
Hypertension/therapy , Quality Assurance, Health Care/methods , Blood Pressure Determination , Clinical Trials as Topic , Education, Continuing/methods , Education, Continuing/organization & administration , Humans , Knowledge of Results, Psychological , Medical Audit , Patient Care Team/organization & administration , Patient Education as Topic/methods , Patient Education as Topic/organization & administration , Reminder Systems
7.
Evid Rep Technol Assess (Full Rep) ; (141): 1-48, 2006 Aug.
Article in English | MEDLINE | ID: mdl-17764208

ABSTRACT

OBJECTIVES: To systematically review the literature about children with anthrax to describe their clinical course, treatment responses, and the predictors of disease progression and mortality. DATA SOURCES: MEDLINE (1966-2005), 14 selected journal indexes (1900-1966) and bibliographies of all retrieved articles. REVIEW METHODS: We sought case reports of pediatric anthrax published between 1900 and 2005 meeting predefined criteria. We abstracted three types of data from the English-language reports: (1) Patient information (e.g., age, gender, nationality), (2) symptom and disease progression information (e.g., whether the patient developed meningitis); (3) treatment information (e.g., treatments received, year of treatment). We compared the clinical symptoms and disease progression variables for the pediatric cases with data on adult anthrax cases reviewed previously. RESULTS: We identified 246 titles of potentially relevant articles from our MEDLINE(R) search and 2253 additional references from our manual search of the bibliographies of retrieved articles and the indexes of the 14 selected journals. We included 62 case reports of pediatric anthrax including two inhalational cases, 20 gastrointestinal cases, 37 cutaneous cases, and three atypical cases. Anthrax is a relatively common and historically well-recognized disease and yet rarely reported among children, suggesting the possibility of significant under-diagnosis, underreporting, and/or publication bias. Children with anthrax present with a wide range of clinical signs and symptoms, which differ somewhat from the presenting features of adults with anthrax. Like adults, children with gastrointestinal anthrax have two distinct clinical presentations: Upper tract disease characterized by dysphagia and oropharyngeal findings and lower tract disease characterized by fever, abdominal pain, and nausea and vomiting. Additionally, children with inhalational disease may have "atypical" presentations including primary meningoencephalitis. Children with inhalational anthrax have abnormal chest roentgenograms; however, children with other forms of anthrax usually have normal roentgenograms. Nineteen of the 30 children (63%) who received penicillin-based antibiotics survived; whereas nine of 11 children (82%) who received anthrax antiserum survived. CONCLUSIONS: There is a broad spectrum of clinical signs and symptoms associated with pediatric anthrax. The limited data available regarding disease progression and treatment responses for children infected with anthrax suggest some differences from adult populations. Preparedness planning efforts should specifically address the needs of pediatric victims.


Subject(s)
Anthrax/diagnosis , Bioterrorism , Adolescent , Adult , Anthrax/drug therapy , Anthrax/etiology , Anthrax/prevention & control , Anthrax/therapy , Bacillus anthracis , Child , Child, Preschool , Humans , Immunization, Passive , Infant , Infant, Newborn , Inhalation Exposure , Skin Diseases, Bacterial/diagnosis , Skin Diseases, Bacterial/drug therapy
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