Subject(s)
Diet , Neoplasms, Experimental/etiology , Neoplasms/etiology , Animals , Antioxidants/adverse effects , Dietary Carbohydrates/adverse effects , Dietary Fats/adverse effects , Dietary Fiber , Dietary Proteins/adverse effects , Disease Models, Animal , Food Additives/adverse effects , Intestinal Neoplasms/etiology , Vitamins/pharmacologyABSTRACT
Sprague-Dawley CD strain rats were given 18, 35, 70, or 140 mg/kg/day of 3-amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline by gavage for 2 weeks. Heinz bodies were seen in the erythrocytes of rats given 140 mg/kg/day. Dose-related increases in methemoglobin were found at 35 mg/kg/day or more. Hemolytic anemia was characterized by dose-related decreases in hematocrit, hemoglobin, and total erythrocyte count. Reticulocytosis, decreased myeloid:erythroid ratio, splenomegaly, extramedullary hematopoiesis, increased serum total bilirubin, and icterus were also observed. This compound was found to oxidize oxyhemoglobin to methemoglobin in vitro, suggesting that the parent compound is capable of causing the hematological changes observed in vivo without conversion to active metabolites.
Subject(s)
Anemia, Hemolytic/chemically induced , Heinz Bodies/drug effects , Methemoglobinemia/chemically induced , Pyrazoles/toxicity , 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine , Animals , Body Weight/drug effects , Erythrocyte Count , Female , Hematocrit , Hemoglobins/metabolism , Male , Oxidation-Reduction , Rats , Rats, Inbred StrainsABSTRACT
Cetaben and clofibrate were each administered to groups of 6 rats (3 male and 3 female) by gavage at dosages of 50 mg/kg per day and 200 mg/kg per day for 2 weeks. Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food consumption at 50 mg/kg per day or more. There were no effects on body weight or food consumption in the clofibrate-treated groups. At 200 mg/kg per day cetaben and clofibrate induced comparable increases in liver weight and in numbers of liver peroxisomes while cetaben caused increases in liver catalase activity as well.
Subject(s)
4-Aminobenzoic Acid/toxicity , Aminobenzoates/toxicity , Clofibrate/toxicity , Hepatomegaly/chemically induced , Hypolipidemic Agents/toxicity , Microbodies/drug effects , Animals , Body Weight/drug effects , Catalase/metabolism , Female , Hepatomegaly/pathology , Lipoproteins/blood , Liver/drug effects , Liver/ultrastructure , Male , Organ Size/drug effects , Rats , para-AminobenzoatesABSTRACT
Buflomedil was administered intravenously to rats at dosages of 1, 4, 12 or 30 mg/kg/day for up to three months. The no-adverse-effect dosage was considered to be 12 mg/kg/day. At 30 mg/kg/day several deaths and clinical signs, including ataxia, decreased activity, dyspnea and jerking movements after dosing, were observed. These were considered to result from the acute, exaggerated pharmacologic effects of buflomedil. Body weight gain and food consumption were decreased after six weeks in males at 30 mg/kg/day. Increases in the relative weights of the kidneys, brain and testes of males at 30 mg/kg/day were correlated with decreased body weight gain in this group. There were no effects on hematology or serum chemistry parameters, and no morphologic changes were found.
Subject(s)
Pyrrolidines/toxicity , Vasodilator Agents/toxicity , Animals , Ataxia/chemically induced , Body Weight/drug effects , Dose-Response Relationship, Drug , Dyspnea/chemically induced , Female , Injections, Intravenous , Male , Organ Size/drug effects , Pyrrolidines/administration & dosage , Rats , Rats, Inbred Strains , Sex Factors , Vasodilator Agents/administration & dosageSubject(s)
Anti-Bacterial Agents/toxicity , Aminoglycosides/metabolism , Aminoglycosides/toxicity , Animals , Body Weight/drug effects , Cats , Dogs , Dose-Response Relationship, Drug , Eating/drug effects , Female , Gentamicins/toxicity , Guinea Pigs , Kidney/drug effects , Male , Mice , Muscles/drug effects , Organ Size/drug effects , Potassium/blood , Rats , Sodium/blood , Vocalization, Animal/drug effectsABSTRACT
Chronic exposure to catalytically treated or noncatalytically treated automobile exhaust significantly depressed the spontaneous locomotor activity (SLA) of rats. Exposure to H2SO4 alone or CO at comparable levels did not alter the SLA. Exposure to noncatalytically treated exhaust resulted in significant reductions in growth rate and food and water intake. However, these effects were not evident in the exposure to catalytically treated exhaust or in the control H2SO4 and CO exposures. Blood acid-base analyses indicated that exposure to either catalytically treated exhaust or H2SO4 elicits a metabolic alkalosis, while exposure to CO alone results in a metabolic acidosis. All acid-base parameters were within the normal range several weeks after the termination of exposure.
