Impact of maternal alcoholism on separation of children from their mothers: findings from a sample of incarcerated women.

Patterns of maternal child co-residence among 25 alcoholic women incarcerated for drunk driving are examined. Two-thirds of these mothers reported significant periods of time, not due to incarceration, when minor children did not reside with them. Fewer than half of the placements were mandated by child-protective services. Having two or more children while actively alcoholic or residing with a substance abuser correlated strongly with separate residence.

Behavioral risk factors related to chronic diseases in ethnic minorities.

This article reviews the evidence on 5 risk behaviors: cigarette smoking, dietary intake, being overweight, limited exercise, and alcohol consumption among African Americans, Asian/Pacific Islanders, Latinos, and Native Americans. Although there is little basis for believing that these high-risk behaviors are any less significant as contributors to chronic disease risk in any ethnic group, the limited information available, especially for Asian/Pacific Islanders and Native Americans, indicates that there may be significant within- and between-group differences in the prevalence of these behaviors. Therefore, some of the ethnic group differences in morbidity and mortality for chronic diseases are partly attributable to differences in behavioral risk profiles. Limited basic health behavior information on most ethnic minority groups delay the development of effective health promotion interventions.

Divided attention task performance and subjective effects following alcohol and placebo: differences between women with and without a family history of alcoholism.

Women with (FHP) and without (FHN) family histories of alcoholism received either 0.56 g/kg alcohol or an isocaloric placebo in a repeated measures group design. Subjects performed a divided attention task and gave subjective ratings of 12 alcohol effects over a 3-h interval. After comparable doses of alcohol, 7 FHP and 10 FHN women had comparable ascending (blood alcohol levels) BALs. BALs peaked earlier for FHP women and then steadily declined. FHP women had a concomitant increase in visual search response times 30 min after alcohol. In contrast, scores on a simultaneously presented compensatory tracking task were virtually identical for the 7 FHP and 10 FHN women after alcohol and for the 8 FHP and 10 FHN women after placebo. After alcohol the FHP and FHN women had 7 out of 12 significantly different subjective ratings of alcohol responses. FHP women had lower subjective responses to alcohol and lower BALs, but their subjective responses were more strongly correlated with BALs. Our findings for women studied in a group design confirm the lower magnitude of subjective responses reported for pair-matched FHP men following comparable doses of alcohol in within-subjects and between-subjects designs in other laboratories.

Components of antisocial personality disorder among women convicted for drunken driving.

For women, the temporal relationship between Antisocial Personality Disorder (ASPD) and alcoholism is unclear. Driving while intoxicated is both a symptom of ASPD and the alcohol-related problem most typically reported by women. Accordingly, a period prevalence sample of 33 women incarcerated for drunken driving offenses was assessed with the SCID to identify other symptoms of ASPD. Excluding behaviors that only occurred while drinking, only 1 of the 33 women met DSM-III-R criteria for ASPD. When behaviors while drinking were included, 18.2% (n = 7) met criteria for ASPD by having both a history of childhood conduct disorder and characteristic ASPD behaviors as adults. However, 57.6% of the sample displayed the pattern of adult behavioral symptoms without a history of childhood conduct disorder (n = 19). Women with a history of conduct disorder and ASPD had a younger mean age of onset of alcohol dependence (16.8 vs 25.6 years) and a higher rate of concurrent borderline personality disorder (85.7 vs 42.1%) than did women who had only adult symptoms of ASPD, but a similar rate of reported parental alcoholism (71.4 vs 72.2%). With one exception, women who were diagnosed with full ASPD with childhood conduct disorder (n = 6) had been truant and had run away from home, but none reported cruelty to animals, vandalism, or arson in childhood. Thus, behaviors diagnostic of ASPD were largely consequent to substance abuse, and childhood behaviors were limited predictors of ASPD. Relationships among gender, prodromal behaviors, and substance abuse appear more complex than anticipated, and they indicate the need to recognize adult onset ASPD associated with substance abuse as a legitimate diagnosis manifested differently by women and men.

Platelet adenylate cyclase and monoamine oxidase in women with alcoholism or a family history of alcoholism.

PURPOSE: Characteristic changes of platelet membrane monoamine oxidase and adenylate cyclase activities have been described in men with alcoholism. We studied the occurrence of these changes in abstinent alcoholic women and in nonalcoholic female control subjects with and without family histories of alcoholism. METHODS: Blood samples were collected from 23 female alcoholics and 39 nonalcoholic female social drinkers. Platelet membrane assays were performed for monoamine oxidase and adenylate cyclase activities. RESULTS: Alcoholic women had lower basal adenylate cyclase (p < 0.01) and adenylate cyclase activities stimulated by cesium fluoride (p < 0.001), by the guanine nucleotide analog 5'-guanylylimidodiphosphate (p < 0.02), and by prostaglandin E1 (p < 0.01). Female control subjects with family histories of alcoholism also had lower basal adenylate cyclase (p < 0.01) and adenylate cyclase activities enhanced by incubation with cesium fluoride (p < 0.005) and 5'-guanylylimidodiphosphate (p < 0.001). Monoamine oxidase activity levels measured with (p < 0.001) and without ethanol (p < 0.01) were higher for alcoholic women. No significant differences were found between female control subjects with and without family histories of alcoholism for monoamine oxidase in the absence or presence of ethanol. DISCUSSION: In vitro platelet adenylate cyclase activity may facilitate a diagnosis of alcoholism in women and may be a biologic indicator of vulnerability in the offspring of alcoholics.

Hyperprolactinemia and macrocytosis in women with alcohol and polysubstance dependence.

Chronic alcoholism and drug abuse are often associated in women with derangements of reproductive function such as amenorrhea, anovulation, luteal phase dysfunction and early menopause. Endocrine profiles were studied of the first 18 women (aged 17-58) admitted consecutively to a Massachusetts hospital for treatment of alcohol/polysubstance dependence under civil commitment. Twelve women were diagnosed as alcohol dependent according to criteria established in DSM-III-R. Their daily alcohol consumption ranged from 42-324 grams. Six women were diagnosed as polysubstance dependent. In addition to alcohol (84-831 g/day), cocaine was the most frequently abused drug followed by tranquilizers, marijuana and opiates. Over 60% of alcohol-dependent women of reproductive age had either hyperprolactinemia or macrocytosis (increased mean corpuscular volume, MCV), or both. Over 60% of the polysubstance-dependent women of reproductive age had either hyperprolactinemia or increased MCV. Over 80% of alcohol-dependent women of postmenopausal age had either hyperprolactinemia or increased MCV, or both. We conclude that evaluation of plasma prolactin levels and MCV may be useful as biological state markers for alcoholism and polysubstance abuse in women.

Prolactin and cortisol levels following acute alcohol challenges in women with and without a family history of alcoholism.

In a pilot study 5 matched pairs of female social drinkers received both 0.56 g/kg alcohol and placebo in a double-blind crossover design. Family history positive (FHP) women had biological fathers who met criteria for alcohol dependence, and FHN women had no relatives who met these criteria. FHP and FHN women had BALs about 70 mg/dl 60 min after alcohol. FHP subjects had significantly lower prolactin levels 40, 60 and 80 min following alcohol, but higher cortisol levels 130 and 150 min following alcohol. No significant differences in hormone levels occurred after placebo.

Putative type II alcoholism characteristics in female third DUI offenders in Massachusetts: a pilot study.

Women who come to the attention of the courts may exhibit heritable Type II alcoholism. Accumulating evidence indicates that more women report having alcoholic parents, that onset of women's alcohol problems before age 25 predicts greater severity of alcohol problems, that women most frequently acknowledge driving while intoxicated (DUI) as an alcohol-related problem, and that the percent of female arrests for DUI has increased. Alcoholic men have been classified as Type I (onset after age 25 and environmentally influenced) or Type II (onset before age 25 with impulsivity and criminal activity) alcoholics. Alcoholism in daughters of Type I fathers is said to occur after age 25 and to be shaped by environmental conditions, but it has been argued that daughters of Type II alcoholic fathers express their family histories in somatization. We report results from a pilot study that found putative Type II alcoholism characteristics, including early age of onset and inability to curtail drinking, in a sample of 12 incarcerated female third DUI offenders.

Some gender differences in alcohol and polysubstance users.

Within the past 20 years, public and professional attention has focused on the legitimacy of research and treatment of substance abuse in women as a "special population." Recent efforts, however, have not as yet closed the gap in knowledge about factors promoting or perpetuating alcohol and other substance use problems in women. Materials that are presented in this article were selected to provide a broad spectrum of information about biological, psychological, and sociocultural aspects of substance abuse as it affects women. Data reported include findings from several studies conducted in our laboratories that have examined these effects. Overall, the discussion summarizes past knowledge, reviews current findings, points to unanswered questions, and concludes with a series of research recommendations that emerge from empirical data.

Operant acquisition of alcohol by women.

Alcohol acquisition and use patterns were studied in 26 women on a clinical research ward. Women could earn alcohol (beer, wine or distilled spirits) or 50 for 30 min of performance on a second-order fixed ratio 300 (fixed interval 1 sec: S) schedule of reinforcement. Points earned for money and for alcohol were not interchangeable. A 7-day drug-free base line was followed by 21 days of alcohol availability and a postalcohol drug-free period of 7 days. Heavy, moderate and occasional drinkers differed significantly in the average number of alcohol drinks purchased (P less than .001). Five heavy drinkers purchased an average of 164 (+/- 14) drinks during the study; 12 moderate drinkers purchased an average of 80 (+/- 4) drinks; 9 occasional drinkers purchased an average of 26 (+/- 4) drinks. Individual drinking patterns fluctuated markedly from day-to-day. Daily peak blood alcohol levels (milligrams per deciliter) were significantly correlated with variations in daily drinking patterns in 22 of the 26 subjects (P less than .02-.0001). Computer analysis of daily alcohol consumption patterns (alcohol peak frequency and peak amplitude) showed that moderate drinkers had significantly more peaks in alcohol consumption than occasional drinkers (P less than .05). The average number of drinks constituting each peak was significantly greater for the heavy and moderate drinkers than for the occasional drinkers (P less than .05). The interval between successive peaks in alcohol consumption averaged 4.6 (+/- 0.8) days for the occasional drinkers, 3.2 (+/- 0.2) days for the moderate drinkers and 3.6 (+/- 0.17) days for the heavy drinkers but these differences were not statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)

Characteristics of women receiving mandated treatment for alcohol or polysubstance dependence in Massachusetts.

Characteristics of the first 20 women consecutively admitted for treatment for alcohol or polysubstance dependence following civil commitment by Massachusetts courts were studied. Women were diagnosed as either alcohol dependent (n = 12) or polysubstance dependent (n = 8). Alcohol dependent women were older at initial alcohol use, onset of regular alcoholic use, first treatment admission, and at this admission. For the group as a whole 75% had completed high school; 50% were divorced and 35% were supported by public assistance. Seventy-five percent had a family history of alcoholism. This sample of women who received court-ordered alcohol and polysubstance dependence treatment had multiple social, psychological, legal and health problems.

Alcohol use and premenstrual symptoms in social drinkers.

The relationship between premenstrual dysphoria and alcohol acquistion and use patterns was studied in 14 women over 35 days on a clinical research ward. A 7-day drug-free baseline was followed by 21 days of alcohol availability and a post-alcohol drug-free period of 7 days. Women could earn alcohol or 50 cents for 30 min of performance on a simple operant task. The Premenstrual Assessment Form (PAF) was administered during baseline and at the premenstruum. Menstrual cycle phase was associated with changes in alcohol use by 8 of the 14 women. Five women drank more during the premenstruum and scored higher on 12 of 18 PAF factors than women whose drinking remained the same (N = 6) or decreased (N = 3). Women who increased drinking had significantly higher PAF scores on impaired social functioning, hostility/anger and hysteroid features (P less than 0.05, 0.01). Women who drank less during the premenstruum reported more pain and physical discomfort, whereas women who drank about the same amount were relatively asymptomatic. PAF profiles reported at the premenstruum and baseline PAF profiles based on recall of the preceding three menstrual cycles were concordant in 13 of the 14 women (P less than 0.001-0.0001). These data suggest that women's perceptions of premenstrual symptomatology are stable through time.

Male heroin addicts and their female mates: impact on disorder and recovery.

A pilot investigation was undertaken to determine whether the social relationships between men who currently used heroin with their female mates differed from those of men who formerly used heroin, but were currently abstinent, with their female mates. Six couples were selected for study via the representative case method. Men currently abstinent from heroin had begun drug use later, had a family history of affective disorders, and had initiated their conjugal relationship after cessation of heroin use. Female mates of males currently abstinent from heroin had never used heroin with their mates in conjunction with sexual activity, had significantly positive ratings of their mates' performance of social roles, and were striving to obtain formal training to improve their employment skills. In contrast, the couples including actively using heroin addicts used opiates together, especially to enhance their sexual activity. The relationships of these couples were not as mutually supportive, and the male's role was less responsible and attracted less respect than that of the abstinent male. The females were depressed and had little positive aspects to their lives. Partners in all couples experienced a large number of stressful events, but current heroin use increased stress and hampered coping efforts. Interaction analysis of dynamics in relationships of men currently abstinent from heroin revealed that participation in mates' family life served to reshape their behaviors into more socially acceptable roles.

Reasons for alcohol use by female heavy, moderate, and occasional social drinkers.

Subjective and behavioral reasons for drinking alcohol were elicited from 26 female social drinkers for 3 points in time by means of standardized questionnaire items selected from the Alcohol Use Inventory and the Alcoholic Stages Index. The 26 women resided for 35 days on a clinical research unit and could consume alcohol on 21 days. On the first study day subjects recalled subjective and behavioral reasons for drinking for the 21 days immediately prior to admission to the study and the 21 days of greatest alcohol consumption during the previous year. On the day after the end of the alcohol acquisition phase of the study, subjects responded to questions about their reasons for alcohol consumption during 21 days on the research unit. Each subject was classified as a heavy, moderate, or occasional drinker on the basis of observed alcohol intake. The heavy, moderate, and occasional drinkers differed significantly in history of alcohol use, and differences in questionnaire response patterns were reported for all 3 time intervals. In contrast to moderate and occasional drinkers, heavy social drinkers had significantly elevated questionnaire item scores for the 21 days of heaviest alcohol consumption during the past year and for the 21 days immediately prior to the study. However, both heavy drinkers and occasional social drinkers had significantly elevated scores for the 21-day alcohol acquisition phase on the research unit. Scores for moderate social drinkers were similar for each of the 3-time intervals.

Alcohol, marijuana, and mood states in young women.

Potential predictors of 8 Profile of Mood States (POMS) factor scores were examined for 30 young women (mean age = 26.4 years). Prospective data were obtained from diary questionnaires and POMS ratings submitted daily during 3 consecutive menstrual cycles. Behavioral and social variables (heavy versus light marijuana smoking, consumption of both marijuana and alcohol on a given day, stress, and sexual activity) were stronger mood factor predictors than temporal or biological variables (weekends or menstrual cycle phase). Heavy marijuana users consistently reported higher negative moods and lower positive moods than light marijuana users.

A microanalysis of ethanol-induced disruption of body sway and psychomotor performance in women.

Measures of body sway, psychomotor performance and subjective reports of intoxication were obtained from 20 women after consuming either ethanol (0.56 g/kg) or placebo. Simple motor tasks were unaffected by the relatively low ethanol dose. Performance on the Digit Symbol Substitution Test (DSST) was affected only during the ascending portion of the blood ethanol curve while stance stability was disrupted during peak and descending blood ethanol levels. A microanalysis of the dynamic changes of ethanol-induced body sway was conducted and the results plotted in three-dimensional space. These data revealed that disruption of stance stability was more pronounced in the sagittal plane than in the lateral plane and that subjects swayed to the rear and the right side. The results of this study suggest that such data analysis techniques provide extremely sensitive measures of body sway resulting from consuming a moderate dose of ethanol.