ABSTRACT
BACKGROUND: Mycobacterium africanum is a cause of tuberculosis (TB) that has mainly been described in Africa, but immigration and travel patterns have contributed to the spread of the disease to other countries. METHODS: We retrospectively reviewed TB cases due to M. africanum during 2000-2010 in seven Spanish hospitals. Selected clinical charts were reviewed using a predefined protocol that included demographical, clinical and microbiological data and outcome. RESULTS: Although 57 cases were diagnosed, only 36 clinical charts were available for review: 82.8% were men and the mean age was 31.6 years (range 12-81). Forty-four cases were from Africa, 1 from the Philippines, 1 from India, and 4 from Spain, while the country of origin was unknown in 7 cases. The most frequent site of infection was the lung (58.3%). Four cases (6.9%) were resistant to at least one first-line anti-tuberculosis drug. CONCLUSIONS: Disease due to M. africanum in industrialised countries is mainly associated with immigration from endemic areas, although some cases also occur among native-born populations.
Subject(s)
Developed Countries , Mycobacterium Infections/epidemiology , Mycobacterium/isolation & purification , Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Male , Middle Aged , Morbidity/trends , Mycobacterium Infections/microbiology , Retrospective Studies , Spain/epidemiology , Young AdultSubject(s)
Brain Abscess/microbiology , Mycobacterium tuberculosis/pathogenicity , Tuberculosis, Central Nervous System/pathology , Brain Abscess/diagnosis , Brain Abscess/pathology , Female , Humans , Tuberculosis, Central Nervous System/diagnosis , Tuberculosis, Central Nervous System/physiopathology , Young AdultABSTRACT
Nontuberculous or environmental mycobacterial disease in children has been increasingly recognized over the last decade. We present four patients who were diagnosed in the year 2000. The children were aged between 2 and 8 years. Three patients presented involvement of the cervical lymph nodes and one presented involvement of the inguinal nodes. Three of the children were treated with a combination of surgery and chemotherapy and one was treated with chemotherapy alone. We describe the clinical characteristics, laboratory findings, therapeutic management and complications of nontuberculous mycobacterial lymphadenitis in children.
Subject(s)
Mycobacterium Infections, Nontuberculous , Mycobacterium kansasii , Mycobacterium scrofulaceum , Age Factors , Anti-Bacterial Agents/therapeutic use , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Lymphadenitis/diagnosis , Lymphadenitis/etiology , Male , Mycobacterium Infections, Nontuberculous/diagnosis , Mycobacterium Infections, Nontuberculous/therapy , Mycobacterium avium-intracellulare Infection/diagnosis , Mycobacterium avium-intracellulare Infection/therapy , Time FactorsABSTRACT
Las enfermedades ocasionadas por micobacterias no tuberculosas o ambientales han aumentado en la última década. Se presentan 4 casos diagnosticados durante el año 2000. Todos los niños tenían entre 2 y 8 años de edad. Tres casos presentaban afectación de los ganglios linfáticos cervicales y un caso de los inguinales. El tratamiento en 3 pacientes fue una combinación de cirugía y quimioterapia y un caso con quimioterapia solamente. En este trabajo se comentan las principales características clínicas, hallazgos de laboratorio, indicaciones terapéuticas y complicaciones de las linfoadenopatías producidas por micobacterias no tuberculosas (AU)
