ABSTRACT
The low strength caused by the single FCC structure of the CrMnFeCoNi high entropy alloy (HEA) limits its application in the field of coating. Here, we prepared high-entropy alloy coatings of CrMnFeCoNi with different ZrC contents on Q235 steel by a plasma transferred arc process. The effects of ZrC on the microstructure and properties of the CrMnFeCoNi HEA coating were investigated by optical microscopy, scanning electron microscope, and X-ray diffraction and by employing a potensiostat/galvanostat. The results showed that ZrC mainly existed in the coatings as a second phase, having little influence on the main crystal structure and micromorphology of the CrMnFeCoNi HEA coating. The hardness of the CrMnFeCoNi HEA coating increased with the ZrC content. ZrC can effectively improve the corrosion resistance of the CrMnFeCoNi HEA coating. In a 1 mol/L NaCl solution with 4 wt% ZrC, the annual corrosion rate was only 5.997% of that of the HEA coating. Nevertheless, the improvement in the wear resistance of CrMnFeCoNi high-entropy alloy coatings was not apparent with the addition of ZrC. Consequently, the addition of ZrC to the FeCoCrNiMn high-entropy alloy coating holds promise for applications in corrosion resistance, particularly in oceanic environments.
ABSTRACT
The high variability of influenza viruses has made it more difficult for people to cope with influenza. When antigen transformation occurs, even new influenza without preventive vaccines may be produced, which poses a great threat to human health. Selenium is an essential trace element in humans and mammals, and has many biological activities. It has attracted people's research interest in recent years. In this study, MDCK cells were used as a model to observe the effect of sodium selenite on H1N1 influenza virus. Our research showed that sodium selenite (Na2SeO3) has an anti-influenza H1N1 virus effect, and the anti-viral effect of sodium selenite was further demonstrated by caspase-3, AKT, MAPK and p53 signaling pathways. The investigations of the mechanism revealed that the sodium selenite could block H1N1 influenza from infecting MDCK cells through inhibiting the production of ROS. The results demonstrate that selenium supplementation may provide a feasible approach to inhibit the infection of H1N1 influenza virus.
ABSTRACT
The critical problem of post-burn depigmentation is the lacking normal melanocytes. Auto-skin grafting and autologous non-cultured epidermal cell suspension have been used to improve the appearance. However, a large amount of skin graft is required of donor sites in the former method, while the latter method is thought to be complicated and costly. This study is designed to generalise the experience of tiny epidermal particles graft (TEPG) for treating post-burn depigmentation. From 2012 to 2013, 30 consecutive patients with depigmentation caused by burn injuries were divided into I and II group. I group: 15 cases (11 males and 4 females) were treated by the TEPG. II group: 15 patients (10 males and 5 females) were treated by suction blister epidermal skin graft (SBEG). Imagine-Pro Plus software was used to evaluate the size of repigmentation (RP) 12 months post-surgery. SPSS software 13.0 was used to evaluate the data. The optimum rate of RP was defined as more than 75% (RP > 75%) when excellent RP was defined as more than 90% (>90%). All patients were followed up for 12 months. The mean size of RP in two groups demonstrated that there were statistically significant differences in pigmentation between the two groups (P = 0·002), while there was no significant difference in the other factors (gender, site and age). No infection occurred in the recipient site. Pathological result showed that melanocytes existed at the basal layer of resurfacing skin. Optimum RP (RP > 75%) was seen in 12 patients in I group and 9 patients in II group. Excellent RP was achieved in 14 cases in I group and 10 patients in II group. Excellent RP can be obtained by the abovementioned two surgical techniques. In contrast to SBEG, TEPG is less traumatic, and definite effects can be guaranteed. It is a preferred treatment, especially for those patients who suffer from large depigmented lesions.
