ABSTRACT
Background: Coronary computed tomography angiogram (CCTA) has the characteristics of non-invasive, high resolution, and can accurately determine the characteristics of tubular wall plaques. The non-calcified plaque loading of the coronary arteries is unstable and prone to shedding, leading to adverse cardiovascular events. However, few studies focused on the predictive value of non-calcified plaque loading for adverse cardiovascular events in patients with unstable coronary heart disease (CHD). The present study was conducted to investigate the association of coronary non-calcified plaque loading based on CCTA and adverse cardiovascular events in patients with unstable CHD. Methods: A total of 206 patients with unstable CHD were collected and followed up for 1 year. The patients were divided into an observation group (n=56) and a control group (n=150) according to whether adverse cardiovascular events occurred or not. We analyzed the predictive value of coronary artery non-calcified plaque loading for adverse cardiovascular events in unstable CHD using receiver operating characteristic and multivariate logistics regression analysis. Results: Compared with the control group, the non-calcified plaque volume in the observation group was increased (160.10±44.02 vs. 128.06±42.22 mm3, P=0.000); non-calcified plaque loading increased (26.93%±7.98% vs. 21.46%±7.62%, P=0.000); carotid intima-media thickness increased (1.49±0.17 vs. 1.40%±0.18 mm, P=0.001); and left ventricular ejection fraction (LVEF) was significantly reduced (53.28%±7.39% vs. 58.02%±7.91%, P=0.000). Non-calcified plaque volume and non-calcified plaque loading have certain diagnostic value for recurrence of adverse cardiovascular events within 1 year (P<0.05). A non-calcified plaque volume >145.58 mm3 is a risk factor for recurrence of adverse cardiovascular events (P<0.05). Conclusions: Increased non-calcified plaque volume in patients with unstable CHD is associated with the development of adverse cardiovascular events in patients with unstable CHD.
ABSTRACT
Magnetic plasmons (MPs) refer to the coupling of external electromagnetic waves with a strong magnetic response induced inside the nanostructures. MPs have been widely employed as artificial magnetic atoms to fabricate negative-permeability or negative-refractive-index metamaterials with peculiar electromagnetic properties. Here, we propose a refractive index sensing by utilizing the MP resonances excited in a simple one-dimensional (1D) metallic nanogroove array. We demonstrate a sensitivity up to 1200 nm/RIU with a figure of merit (FOM*) of 15 thanks to the MP resonances that are extremely sensitive to the surrounding media. Importantly, the influence of the local environment effects on the sensing ability is studied. An equivalent inductor-capacitor (LC) model is used to give a precise quantitative description of the sensing performance and reveal the underlying mechanism. Such a MP-based sensor with the ease of fabrication may provide great potentials in designing broadband sensing devices with high performance and compactness.
