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1.
Front Psychol ; 14: 1235735, 2023.
Article in English | MEDLINE | ID: mdl-37711319

ABSTRACT

A growing number of studies show a processing advantage for collocations, which are commonly-used juxtapositions of words, such as "joint effort" or "shake hands," suggesting that skilled readers are keenly perceptive to the occurrence of two words in phrases. With the current research, we report two experiments that used eye movement measures during sentence reading to explore the processing of four-character verb-noun collocations in Chinese, such as ("revise the article"). Experiment 1 compared the processing of these collocations relative to similar four-character expressions that are not collocations (e.g., , "revise the ending") in neutral contexts and contexts in which the collocation was predictable from the preceding sentence context. Experiment 2 further examined the processing of these four-character collocations, by comparing eye movements for commonly-used "strong" collocations, such as ("protect the environment"), as compared to less commonly-used "weak" collocations, such as ("protect nature"), again in neutral contexts and contexts in which the collocations were highly predictable. The results reveal a processing advantage for both collocations relative to novel expressions, and for "strong" collocations relative to "weak" collocations, which was independent of effects of contextual predictability. We interpret these findings as providing further evidence that readers are highly sensitive to the frequency that words co-occur as a phrase in written language, and that a processing advantage for collocations occurs independently of contextual expectations.

2.
J Psycholinguist Res ; 52(5): 1439-1454, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37043154

ABSTRACT

Reading can be regarded as a combination of lexical decoding and linguistic comprehension (Hoover and Gough in Read Writ Interdiscip J 2:127-160, 1990). In Chinese sentence reading, skilled readers' difficulties in phonological processing significantly enhance the 'wrap-up' effect (Li and Lin in J Deaf Stud Deaf Educ 25(4):505-516, 2020). To examine how orthographic processing in Chinese two-character word recognition might interact with adjective-noun collocation (ANC) comprehension before the wrap-up effect, two experiments were conducted in the same paradigm as used by Li and Lin (J Deaf Stud Deaf Educ 25(4):505-516, 2020). The sentences contained ANCs or semantically inappropriate combinations of adjectives and nouns (nANCs), the adjectives (Experiment 1) or the nouns (Experiment 2) of which were two-character words or corresponding transposed nonwords (T-nonwords). Similar results were obtained in both experiments: difficulties in T-nonword processing and in nANC comprehension collectively lengthened the reading times of the words immediately following. In conclusion, sentence reading likely contains interactions between orthographic processing and linguistic comprehension. As an indication of psycholinguistic significance, skilled readers have to use extra resources to suspend the cognitive vigilance that arises from unexpected demand in lexical decoding, in addition to their main focus of linguistic comprehension.


Subject(s)
Comprehension , East Asian People , Reading , Humans , Asian People , Language , Psycholinguistics
3.
Heliyon ; 9(1): e13043, 2023 Jan.
Article in English | MEDLINE | ID: mdl-36747945

ABSTRACT

To address the controversy on cognitive resources sharedness between language and music in semantic processing, two experiments were conducted via the interference paradigm using the Event-Related Potential (ERP) technique. In Experiment 1, a five-word sentence and a five-chord sequence were simultaneously presented in a trial. The sentence (e.g., '/*,' The policeman found a mobile phone/wallet) ended with a semantically acceptable or unacceptable number-classifier-noun collocation (NCN), and the final chord of the chord sequence was congruent or incongruent with the preceding chords in tone. The stimuli in Experiment 1 were adapted in Experiment 2: The particle '' was removed, and a three-word-long, object-gap relative clause was inserted ahead of the noun of the NCN in each sentence; two chords were inserted ahead of the third chord in each chord sequence. Both similarities and differences were revealed between Experiments 1 and 2, concerning the influences of the manipulated variables on the amplitude of the ERP component N400. In conclusion, the dissolution of semantic violation in sentence reading was likely to happen in parallel with music processing in chord sequence comprehension by non-musician Chinese native speakers, but interaction was observable between language and music in semantic processing when the sentences ended with long-distance NCNs.

4.
J Psycholinguist Res ; 51(1): 195-216, 2022 Feb.
Article in English | MEDLINE | ID: mdl-34997424

ABSTRACT

In Chinese, the graphic units are Chinese characters, most of which are compound characters. Since a compound character can be different from another one in being regarded as composed of components (compositionality), readers might have developed a compositionality awareness of the constituent characters in two-character word (2C-word) recognition. Two experiments were conducted in a lexical decision task on the same set of 2C-words, the first constituent characters of which were manipulated in compositionality. Given that a Chinese character is more difficult to recognize when it is presented upside-down than when it is presented in an upright orientation and that it is inevitable to perceive the constituent characters in 2C-word recognition, we manipulated the first constituent characters' presentation orientation to increase the task difficulty. The two constituent characters of a 2C-word target were displayed simultaneously in a trial in Experiment 1 but were shown sequentially in Experiment 2. Participants were two cohorts of adult Chinese native speakers (CNS1s and CNS2s). CNS1s had a significantly lower level of reading proficiency than CNS2s. The influence of orientation was observed in both CNS1s and CNS2s' performance across the two experiments, but only CNS2s' reaction times seemed to have indicated the effect of compositionality in Experiment 2. Skilled readers are more likely than less skilled readers to be conscious of compositionality of the first constituent characters, which are presented separately from the second ones, in 2C-word recognition.


Subject(s)
Pattern Recognition, Visual , Reading , Adult , China , Humans , Reaction Time , Recognition, Psychology
5.
Am Ann Deaf ; 165(5): 483-509, 2021.
Article in English | MEDLINE | ID: mdl-33678716

ABSTRACT

To examine deaf and hard of hearing (DHH) students' configurational and phonological processing in Chinese one- and two-character word recognition, two experiments were conducted in a primed semantic categorization task. Configurational priming was observed in DHH participants' reaction times (RTs) at the SOA (stimulus onset asynchrony) of 47 ms and in their probability of making erroneous responses at SOAs of 47 and 187 ms in Experiment 1. Phonological priming was revealed in hearing and DHH participants' probability of making erroneous responses in Experiment 2. Hearing participants' RTs indicated facilitation and inhibition at the SOAs of 47 and 187 ms, respectively; DHH participants' RTs showed priming at the SOA of 187 ms. It is concluded that DHH college students are more likely to use the configurational information but less likely to use the phonological information than hearing college students in one- and two-character word recognition.


Subject(s)
Deafness/psychology , Pattern Recognition, Visual , Persons With Hearing Impairments/psychology , Students/psychology , Adolescent , Adult , China , Female , Humans , Language , Male , Phonetics , Reaction Time , Reading , Repetition Priming , Semantics , Young Adult
6.
J Deaf Stud Deaf Educ ; 25(4): 505-516, 2020 09 10.
Article in English | MEDLINE | ID: mdl-32472118

ABSTRACT

To examine deaf and hard-of-hearing (DHH) students' awareness of phoneme repetition in Chinese sentence reading, two experiments were conducted in the self-paced, moving-window reading paradigm. The materials comprised sentences in which Chinese characters that sequentially followed each other shared similar spelling initials and finals in Experiments 1 and 2, respectively. In comparison to hearing participants, DHH participants were more likely to find it more time-consuming to read sentences with, as opposed to without, phoneme repetitions. However, their difficulty in phonological processing seemed to be linked to their weakness at syntactic skilfulness, thus having a negative influence on their reading performance. It is concluded that Chinese DHH college students have developed a phoneme repetition awareness which is different from how hearing college students are aware of phoneme repetitions in Chinese sentence reading. It is implicated that DHH students are able to develop their own skills of phonological information processing in sentence reading as a result of many practices.


Subject(s)
Awareness , Persons With Hearing Impairments/psychology , Phonetics , Reading , China , Comprehension , Female , Humans , Language , Male , Young Adult
7.
J Deaf Stud Deaf Educ ; 24(3): 270-279, 2019 07 01.
Article in English | MEDLINE | ID: mdl-31158291

ABSTRACT

Irony comprehension can be a kind of challenge to those who are relatively less skillful in reading. To examine how DHH college students (DCSs) were different from hearing college students (HCSs) in the reading of ironic discourses, we conducted two experiments in the self-paced reading task. In Experiment 1, the statement was either literally congruent with the preceding context or had to be understood in an ironic way in each trial; In Experiment 2, the statement was the same but the context was not across the two levels of discourse type. The DCSs generally had a poorer performance than the hearing participants. Although able to comprehend ironies, they had a significantly lower efficiency than their hearing counterparts. The results were consistently in agreement with the prediction of the graded salience hypothesis (Giora, R. (1997). Understanding figurative and literal language: The graded salience hypothesis. Cognitive Linguistics, 7, 183-206. doi:10.1515/cogl.1997.8.3.183) and the parallel-constraint-satisfaction framework (Pexman, P. M. (2008). It's fascinating research. Current Directions in Psychological Science, 17(4)286-290. doi:10.1111/j.1467-8721.2008.00591.x), and the DCSs' performance appears to indicate an amplified version of this support. It is implied that educational environments should be created in which deaf and DHH students are encouraged to do as much reading as possible. Exercises should be designed in helping them to improve vocabulary and syntactic skills in general and to improve skills of inference-making in particular.


Subject(s)
Comprehension/physiology , Hearing Disorders/psychology , Language , Persons With Hearing Impairments/psychology , Reading , Emotions , Female , Humans , Male , Students/psychology , Young Adult
8.
Am Ann Deaf ; 163(5): 554-573, 2019.
Article in English | MEDLINE | ID: mdl-30713198

ABSTRACT

Deaf and hard of hearing (DHH) students tend to experience delayed development of grammatical skills in written language. However, much remains unknown about the mechanism behind this phenomenon. In the present study, the researchers used a self-paced moving-window reading task to investigate DHH students' understanding of causal and adversative connectives in Chinese. The students were similar to a hearing control group in their comprehension of the relationship between the clauses in a causal sentence. However, the DHH students were more likely than their hearing peers to find it harder to understand adversative connectives than causal connectives. More studies are needed to reveal how DHH students deal with other syntactic structures that are particularly difficult for them to learn. Educators should pay close attention to creating learning environments in which DHH students can acquire those syntactic structures in the process of using language.


Subject(s)
Comprehension , Deafness/psychology , Education of Hearing Disabled , Reading , Adolescent , Female , Humans , Linguistics , Male , Reaction Time , Young Adult
9.
Am Ann Deaf ; 161(3): 303-13, 2016.
Article in English | MEDLINE | ID: mdl-27477038

ABSTRACT

An affective priming task was used with two cohorts of college students, one deaf or hard of hearing (D/HH), the other hearing, in two experiments. The same set of affective-word targets, preceded by "※※" in Experiment 1 but by affective-word primes of the same valence as the targets in Experiment 2, were presented vertically above or below the screen center. Stimuli that preceded the targets were shown at the screen center. D/HH participants generally performed more poorly than hearing participants, but both groups performed similarly in that both did better on the positive targets than on the negative in both experiments, and on supporting metaphorical associations between valence and vertical positions (Meier & Robinson, 2004), as indicated by reaction times, in Experiment 2. The researchers concluded that D/HH and hearing college students perform similarly in developing cognition-grounded representations of affective words in written language.


Subject(s)
Affect , Awareness , Cognition , Deafness/psychology , Linguistics , Persons With Hearing Impairments/psychology , Students/psychology , Deafness/diagnosis , Female , Humans , Male , Reaction Time , Repetition Priming , Time Factors , Young Adult
10.
Behav Res Methods ; 48(4): 1678-1693, 2016 12.
Article in English | MEDLINE | ID: mdl-26822667

ABSTRACT

The most important forms of idioms in Chinese, chengyus (CYs), have a fixed length of four Chinese characters. Most CYs are joined structures of two, two-character words-subject-verb units (SVs), verb-object units (VOs), structures of modification (SMs), or verb-verb units-or of four, one-character words. Both the first and second pairs of words in a four-word CY form an SV, a VO, or an SM. In the present study, normative measures were obtained for knowledge, familiarity, subjective frequency, age of acquisition, predictability, literality, and compositionality for 350 CYs, and the influences of the CYs' syntactic structures on the descriptive norms were analyzed. Consistent with previous studies, all of the norms yielded a high reliability, and there were strong correlations between knowledge, familiarity, subjective frequency, and age of acquisition, and between familiarity and predictability. Unlike in previous studies (e.g., Libben & Titone in Memory & Cognition, 36, 1103-1121, 2008), however, we observed a strong correlation between literality and compositionality. In general, the results seem to support a hybrid view of idiom representation and comprehension. According to the evaluation scores, we further concluded that CYs consisting of just one SM are less likely to be decomposable than those with a VOVO composition, and also less likely to be recognized through their constituent words, or to be familiar to, known by, or encountered by users. CYs with an SMSM composition are less likely than VOVO CYs to be decomposable or to be known or encountered by users. Experimental studies should investigate how a CY's syntactic structure influences its representation and comprehension.


Subject(s)
Language , Adolescent , Asian People , Comprehension , Female , Humans , Male , Psycholinguistics , Reference Values , Reproducibility of Results , Semantics , Young Adult
11.
Front Psychol ; 6: 693, 2015.
Article in English | MEDLINE | ID: mdl-26074847

ABSTRACT

After judging the valence of the positive (e.g., happy) and the negative words (e.g., sad), the participants' response to the letter (q or p) was faster and slower, respectively, when the letter appeared at the upper end than at the lower end of the screen in Meier and Robinson's (2004) second experiment. To compare this metaphorical association of affect with vertical position in Chinese-English bilinguals' first language (L1) and second language (L2) (language), we conducted four experiments in an affective priming task. The targets were one set of positive or negative words (valence), which were shown vertically above or below the center of the screen (position). The primes, presented at the center of the screen, were affective words that were semantically related to the targets, affective words that were not semantically related to the targets, affective icon-pictures, and neutral strings in Experiment 1-4, respectively. In judging the targets' valence, the participants showed different patterns of interactions between language, valence, and position in reaction times across the experiments. We concluded that metaphorical association between affect and vertical position works in L1 but not in L2 for unbalanced bilinguals.

12.
Am Ann Deaf ; 160(1): 48-59, 2015.
Article in English | MEDLINE | ID: mdl-26004975

ABSTRACT

Two experiments investigated Chinese deaf and hard of hearing (DHH) adolescents' recognition of category names in an innovative task of semantic categorization. In each trial, the category-name target appeared briefly at the screen center followed by two words or two pictures for two basic-level exemplars of high or middle typicality, which appeared briefly approximately where the target had appeared. Participants' reaction times when they were deciding whether the target referred to living or nonliving things consistently revealed the typicality effect for the word, but a reversed-typicality effect for picture-presented exemplars. It was found that in automatically processing a category name, DHH adolescents with natural sign language as their first language evidently activate two sets of exemplar representations: those for middle-typicality exemplars, which they develop in interactions with the physical world and in sign language uses; and those in written-language learning.


Subject(s)
Education of Hearing Disabled/methods , Language Development , Persons With Hearing Impairments/psychology , Recognition, Psychology , Semantics , Visual Perception , Adolescent , China , Female , Humans , Learning , Male , Photic Stimulation , Reaction Time , Sign Language , Time Factors , Vocabulary , Young Adult
13.
Front Psychol ; 6: 1918, 2015.
Article in English | MEDLINE | ID: mdl-26779064

ABSTRACT

To separate the contribution of phonological from that of visual-orthographic information in the recognition of a Chinese word that is composed of one or two Chinese characters, we conducted two experiments in a priming task of semantic categorization (PTSC), in which length (one- or two-character words), relation, prime (related or unrelated prime-target pairs), and SOA (47, 87, or 187 ms) were manipulated. The prime was similar to the target in meaning or in visual configuration in Experiment A and in meaning or in pronunciation in Experiment B. The results indicate that the two-character words were similar to the one-character words but were less demanding of cognitive resources than the one-character words in the processing of phonological, visual-orthographic, and semantic information. The phonological primes had a facilitating effect at the SOA of 47 ms but an inhibitory effect at the SOA of 187 ms on the participants' reaction times; the visual-orthographic primes only had an inhibitory influence on the participants' reaction times at the SOA of 187 ms. The visual configuration of a Chinese word of one or two Chinese characters has its own contribution in helping retrieve the word's meanings; similarly, the phonological configuration of a one- or two-character word plays its own role in triggering activations of the word's semantic representations.

14.
Am Ann Deaf ; 158(4): 426-37, 2013.
Article in English | MEDLINE | ID: mdl-24724307

ABSTRACT

Inspired by research by Li, Yi, and Kim (2011), the authors examined Chinese deaf and hard of hearing adolescents' responses to pictures for taxonomic categories of basic level (exemplar pictures) preceded by exemplar pictures, and to written words for taxonomic categories of basic level (exemplar words) preceded by exemplar words or by written words for those of superordinate level (category names), in a priming task of semantic categorization. Stimulus onset asynchrony (SOA) was manipulated. The adolescents were less aware of taxonomic relations and were more likely to show the advantage of pictures over written words than their hearing counterparts. Their processing of exemplar primes steadily deepened as SOA increased, reaching its deepest level when SOA was 237 ms. Their processing of category names seemed immune to changes in SOA, probably because of their fuzzy representations of taxonomic categories of superordinate level.


Subject(s)
Deafness/psychology , Language Development , Persons With Hearing Impairments/psychology , Reading , Semantics , Visual Perception , Adolescent , Adolescent Behavior , Asian People/psychology , Awareness , China , Deafness/ethnology , Female , Humans , Male , Photic Stimulation , Reaction Time , Recognition, Psychology , Time Factors
15.
Am Ann Deaf ; 156(5): 476-91, 2012.
Article in English | MEDLINE | ID: mdl-22524093

ABSTRACT

Inspired by a previous study of Korean deaf and hard of hearing adolescents, the researchers conducted a priming task of living-nonliving categorization with a sample of Chinese deaf and hard of hearing adolescents. The sample in this study had significantly lower accuracy levels for the thematically related items than for the taxonomically related items and significantly larger differences in reaction times than a group of hearing adolescents when stimuli were changed from pictures to written words. However, they were not significantly different from the hearing adolescents in their performance with the taxonomically related written words. Furthermore, unlike the hearing adolescents, they did not have significantly different reaction times as the result of changes in positions of stimulus presentations.


Subject(s)
Asian People/psychology , Deafness/psychology , Deafness/rehabilitation , Hearing Loss/psychology , Hearing Loss/rehabilitation , Linguistics , Adolescent , Correction of Hearing Impairment , Deafness/ethnology , Female , Hearing Loss/ethnology , Humans , Male , Reading
16.
Scand J Psychol ; 53(3): 191-9, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22380641

ABSTRACT

The development of representations for taxonomic categories is influenced by many factors, such as age, life experiences, and education. It was hypothesized that Mosuos might be aware of taxonomic relations differently than Hans, as indicated by Sha (1996). Three experiments--word associations, lexicon decisions, and semantic categorizations--were conducted on young adults of Mosuos and Hans and consistent results were obtained: the Mosuos were found both similar to and different from the Hans in their experimental performance. They were apparently aware of taxonomic relations less than the Hans among categories of different levels and among categories of basic level, consistent with the conclusion that the uniqueness of a specific culture influences the people's representations for the hierarchically structured taxonomic categories (López, Atran, Coley, Medin & Smith, 1997). The present forms of education did not seem to be as effective as educators expected to help promote Mosuo children's development of knowledge of taxonomic categories. If school education would be available that is compatible with the cultural value of a relatively isolated, small population, such as Mosuos, and is of practical value for the young children to develop a better knowledge of the world, then a study would be of critical value into how educated individuals would be different from uneducated ones in their awareness of taxonomic relations.


Subject(s)
Awareness , Culture , Language , Vocabulary , Adolescent , Adult , China , Decision Making , Educational Status , Female , Humans , Male , Semantics
17.
J Deaf Stud Deaf Educ ; 16(3): 375-91, 2011.
Article in English | MEDLINE | ID: mdl-21325426

ABSTRACT

Individuals' relative awareness of thematic and taxonomic relations is influenced by factors such as language and background knowledge. Relatively weak in Korean language skills and also having relatively limited social opportunities, Korean deaf adolescents might be different from hearing adolescents in how they make decisions in taxonomically and thematically associated entities represented by pictures and words. Experiment 1 indicated that deaf adolescents had longer reaction times than hearing adolescents in a forced-choice decision-making task. Both deaf and hearing adolescents had shorter reaction times and higher accuracies with pictures than with words, but deaf adolescents' differences were bigger than those of hearing adolescents. Experiment 2 further showed that deaf adolescents had lower accuracies than hearing adolescents in a priming task of living-nonliving categorization. Both deaf and hearing adolescents had shorter reaction times with taxonomic than with thematic categories, but deaf adolescents' difference was bigger than that of hearing adolescents. In conclusion, Korean deaf adolescents were aware of thematic and taxonomic relations less than hearing adolescents in general. They were more likely than hearing adolescents to show the advantage of pictures over words in their performance in conceptual activities and to prefer taxonomic to thematic associations for written words in Experiment 2.


Subject(s)
Asian People , Awareness , Classification , Deafness/psychology , Language , Adolescent , Choice Behavior , Concept Formation , Decision Making , Female , Humans , Male , Models, Psychological , Reaction Time
18.
Scand J Psychol ; 52(2): 105-12, 2011 Apr.
Article in English | MEDLINE | ID: mdl-21077904

ABSTRACT

Deaf college students seem to have relatively stronger associations from words for taxonomic categories of basic (e.g., snake) to those of super-ordinate (e.g., reptiles) level than vice versa compared with hearing students in word association (Marschark, Convertino, McEvoy & Masteller, 2004). In deciding whether two sequentially presented words for taxonomic categories of different levels are conceptually related, deaf adolescents might therefore have a poorer performance when they see a category name before than when they see it after one of the corresponding exemplar words. Deaf Korean adolescents were found to recognize words for taxonomic categories of super-ordinate level with lower efficiencies than those of basic level. Their accuracy seemed to reflect a reversed typicality effect when they decided that first-presented words for taxonomic categories of basic level were conceptually related to second-presented words for those of super-ordinate level. It was argued that deaf Korean adolescents went through a temporary stage of having iconic representations of several exemplars of the category aroused in working memory before the abstract semantic representation was fully activated when they saw the word for a taxonomic category of super-ordinate level.


Subject(s)
Deafness/psychology , Learning , Recognition, Psychology , Vocabulary , Adolescent , Analysis of Variance , Asian People , Child , Deafness/physiopathology , Female , Humans , Male , Reaction Time
19.
Scand J Psychol ; 50(4): 355-66, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19392942

ABSTRACT

Four experiments were conducted to show that deaf adolescents tended to process information in different ways from hearing adolescents. Memorizing items sequentially shown on computer screens under the control of their articulators' movements, deaf adolescents tended to treat items that cohered as taxonomic, thematic, or slot-filler categories as isolated pieces of information. Having to perceive information by means of sign language, however, their achievements were not worse than those of hearing adolescents anymore, no matter whether the stimuli were presented as words or pictures. They could not only utilize categories relations to help memorize categories exemplars but were relatively better aware of slot-filler or thematic than taxonomic relations as well, suggesting that they had a relatively delayed development of taxonomic category representations in comparison with hearing adolescents.


Subject(s)
Concept Formation , Deafness/psychology , Mental Recall , Sign Language , Verbal Learning , Adolescent , Attention , Case-Control Studies , China , Female , Hand , Humans , Male , Matched-Pair Analysis , Mouth , Movement , Semantics
20.
Chin Med J (Engl) ; 121(18): 1787-91, 2008 Sep 20.
Article in English | MEDLINE | ID: mdl-19080358

ABSTRACT

BACKGROUND: Patients with myelodysplastic syndrome (MDS) display a very diverse pattern. In this study, we investigated prognostic factors and survival rate in adult patients with MDS refractory anaemia (MDS-RA) diagnosed according to French-American-British classification and evaluated the International Prognostic Scoring System (IPSS) for Chinese patients. METHODS: A multi-center study on diagnosis of MDS-RA was conducted to characterize the clinical features of Chinese MDS patients. The morphological criteria for the diagnosis of MDS-RA were first standardized. Clinical data of 307 MDS-RA patients collected from Shanghai, Suzhou and Beijing from 1995 to 2006 were analyzed using Kaplan-Meier curve, log rank and Cox regression model. RESULTS: The median age of 307 MDS-RA cases was 52 years. The frequency of 2 or 3 lineage cytopenias was 85.6%. Abnormal karyotype occurred in 35.7% of 235 patients. There were 165 cases (70.2%) in the good IPSS cytogenetic subgroup, 44 cases (18.7%) intermediate and 26 cases (11.1%) poor. IPSS showed 20 (8.5%) categorized as low risk, 195 cases (83.0%) as intermediate-I risk and 20 cases (8.5%) as intermediate-II risk. The 1-, 2-, 3-, 4- and 5-year survival rates were 90.8%, 85.7%, 82.9%, 74.9% and 71.2% respectively. Fifteen cases (4.9%) transformed to acute myeloid leukaemia (median time 15.9 months, range 3 - 102 months). Lower white blood cell count (< 1.5 x 10(9)/L), platelet count (< 30 x 10(9)/L) and cytogenetic abnormalities were independent prognostic factors by multivariate analysis, but age (= 65 years), IPSS cytogenetic subgroup and IPSS risk subgroup were not independent prognostic factors associated with survival time. CONCLUSIONS: Chinese patients were younger, and had lower incidence of cytogenetic abnormalities, more severe cytopenias but a more favourable prognosis than Western patients. The major prognostic factors were lower white blood cell count, lower platelet count and fewer abnormal karyotypes. The international prognostic scoring system risk group was not an independent prognostic factor for Chinese myelodysplastic syndrome patients with refractory anaemia patients.


Subject(s)
Anemia, Refractory/etiology , Myelodysplastic Syndromes/complications , Adolescent , Adult , Aged , Aged, 80 and over , Anemia, Refractory/mortality , Asian People , Child , China , Female , Humans , Male , Middle Aged , Myelodysplastic Syndromes/mortality , Prognosis
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