[Multidisciplinary approach to diagnose the sarcoidosis of small intestine].

In the article the clinical case of sarcoidosis of the GI tract as a rare form. Clinical form and the diagnosis of GI tract sarcoidosis are described.

[Manifestations of gastroesophageal reflux disease in the oral cavity].

Were examined clinical and laboratory examined 138 patients: 93 people with gastroesophageal reflux disease (GERD) in whose mouth there were changes in the periodontal tissues, and 45 people without a concomitant GERD with help of clinical and laboratory methods. All patients were conducted to clinical examination of the oral cavity with the establishment of periodontal status on the basis of "Florida Proub" system and evaluation index. During the study was analyzed the major dental complaints as "extraesophageal" symptoms in patients with reflux esophagitis, as well as evaluation of the inflammatory process in periodontal tissues, depending on the stage of GERD.

[Risk and prevention of atrial fibrillation of non-valvular origin]. / Risk i profilaktika fibrilliatsii predserdii neklapannoi étiologii.

Atrial fibrillation (AF) is an independent risk factor for ischemic stroke. In patients with AF, cardioembolias present about 10% of ischemic strokes. Transesophageal echocardiography is an ideal instrument for diagnostics of intracardiac thrombi. An aim of the study was to find the high risk markers for stroke in patients with AF of non-valvular origin. The patients have been divided into 2 groups with and without stroke in anamnesis. To search for stroke dependence of clinical and echocardiographic high risk markers, the data were analyzed using Poly Analyst Power statistical package. In the group of the patients with stroke in the anamnesis, echocardiographic markers for high risk of thromboembolia occurred significantly more frequently. Thrombi in the left atrial or its appendage were registered in 12.5% patients without stroke in anamnesis and in 31% of those, who survived stroke. The independent risk factors for stroke were age, AF duration, left ventricular ejection fraction, diabetes mellitus and arterial hypertension.

[Experience in the use of eiconol (a complex of unsaturated fatty acids) in non-insulin-dependent diabetes mellitus]. / Opyt ispol'zovaniia éikonola (kompleksa nenasyshchennykh zhirnykh kislot) pri insulinezavisimom sakharnom diabete.

Cardiovascular disease is the principal cause of morbidity, functional disability and fatal outcomes in patients with non-insulin-dependent diabetes mellitus (NIDDM). The results of administration of eikonol, food additive containing omega-3 unsaturated fatty acids, for 3 months were analyzed for 60 elderly NIDDM patients with ischemic heart disease. A single administration of eikonol leads to a decrease in accumulation of intracellular cholesterol by 15%. Diet eikonol decreased the level of total cholesterol and triglycerides in the blood by 23 and 43%, respectively. Moreover, the higher is the initial value of these parameters, the higher is the effect of the preparation. Eikonol proved to increase the level of lipoproteins of high density, produced a positive trends in NIDDM clinical picture. Food additive eikonol is recommended for wide administration in elderly NIDDM patients with atherogenic dyslipidemias.

[Changes in the level of polyunsaturated fatty acids, substrates and inhibitors of thromboxane and prostacyclin synthesis, in the blood of patients with cardiovascular diseases]. / Izmenenie urovnei polinenasyshchennykh zhirnykh kislot--substratov i ingibitorov sinteza tromboksana i prostatsiklina--v plazme krovi cheloveka pri serdechno-sosudistykh zabolevaniiakh.

The authors examined the ratios of blood free polyunsaturated fatty acids (PUFA), such as 20:3n6, 20:4n6, 20:5n3, and 22:6n3, which are substrates and inhibitors of synthesis of thromboxane A2 and prostacyclins that regulate both normal blood fluidity, and platelet adhesion and primary thrombogenesis. The object of the study was plasma from healthy subjects and 4 groups of patients with cardiovascular diseases: 1) large myocardial infarction; 2) resting and exercise-induced angina pectoris; 3) large myocardial infarction; and 4) recurrent myocardial infarction. The levels of plasma free PUFA were measured by gas chromatography. Assessment of the PUFA ratios indicated that the risk for thrombogenesis increased in large and recurrent myocardial infarctions as compared to small myocardial infarction and angina pectoris both by reducing the relative levels of 20:3n6 and, in particular, 20:5n3, substrates of synthesis of only thrombolytics and vasodilators and by more greatly inhibiting the synthesis of prostacyclins than thromboxane with elevated 22:6n3 levels.

[The action of obzidan and oktadin on muscle blood flow during head-down tilt hypokinesia]. / Deistvie obzidana i oktadina na myshechnyi krovotok v usloviiakh antiortostaticheskoi gipokinezii.

The blood flow in the gastrocnemius muscle of healthy men was studied during 6-hour antiorthostatic hypokinesia at different angles (-7, -15, -22, -30 degrees) and also the possibility of correcting changes in hemodynamics during antiorthostatic hypokinesia was determined. The muscle blood flow was studied by the clearance method. A total of 72 tests were performed. The tested men received obsidan and octadine 30 minutes before taking the antiorthostatic position in doses of 80 and 12.5 mg for one intake respectively. The analysis of the clinical data showed that typical symptomatology develops during antiorthostatic hypokinesia with a significant decrease of the tissue blood flow in the gastrocnemius muscle at an increase of the angle of tilt. The results of the studies suggested that obsidan fails to improve the muscle blood flow and octadine leads to a greater slowing of the muscle blood flow that negatively influences the condition of the gastrocnemius muscle.

[Comparative study of the effect of trental, menthol and obzidan and their combinations on the function of the cardiorespiratory system in operators under extreme conditions]. / Sravnitel'noe izuchenie vliianiia trentala, mentola i obzidana i ikh kombinatsii na sostoianie kardiorespiratornoi sistemy u operatorov v ékstremal'nykh usloviiakh.

Effects of different drugs on parameters of gas exchange and central hemodynamics were studied during physical load in operators under antiorthostatic hypokinesia at an angle of 15 degrees. More significant tension of the cardiorespiratory system during physical load was found following administration of beta-blockers.

[Effect of beta-adrenergic blockaders and trental on plasma levels of renin and aldosterone in healthy persons during antiorthostatic hypokinesia]. / Vliianie beta-adrenergicheskikh blokatorov i trentala na soderzhanie renina i aldosterona v plazme krovi zdorovykh lits v usloviiakh antiortostaticheskoi gipokinezii.

Plasma renin activity and aldosterone levels were measured radioimmunologically in 30 normal individuals subjected to antiorthostatic hypokinesia (at a - 15 degrees angle). Hormonal effects of some drugs (beta-blockers, trental, venotonics) were examined. The short-term antiorthostatic position was associated with a disordered hormonal control, reduced plasma aldosterone and enhanced plasma renin activity, as compared to the respective parameters of the reclining position. The use of beta-adreno-blockers alone or in combinations with other drugs decreases plasma renin activity in conditions of antiorthostatic hypokinesia which can be related to the inhibition of beta-adrenergic activity.