ABSTRACT
Early diagnosis of Alzheimer's disease (AD) is crucial for its prevention, and hippocampal atrophy is a significant lesion for early diagnosis. The current DL-based AD diagnosis methods only focus on either AD classification or hippocampus segmentation independently, neglecting the correlation between the two tasks and lacking pathological interpretability. To address this issue, we propose a Reliable Hippo-guided Learning model for Alzheimer's Disease diagnosis (RLAD), which employs multi-task learning for AD classification as a main task supplemented by hippocampus segmentation. More specifically, our model consists of 1) a hybrid shared features encoder that encodes local and global information in MRI to enhance the model's ability to learn discriminative features; 2) Task Specific Decoders to accomplish AD classification and hippocampus segmentation; and 3) Task Coordination module to correlate the two tasks and guide the classification task to focus on the hippocampus area. Our proposed RLAD model is evaluated on MRI scans of 1631 subjects from three independent datasets, including ADNI-1, ADNI-2, and HarP. Our extensive experimental results demonstrate that the proposed model significantly improves the performance of AD classification and hippocampus segmentation with strong generalization capabilities. Our implementation and model are available at https://github.com/LeoLjl/Explainable-Alzheimer-s-Disease-Diagnosis.
ABSTRACT
In the past decade, deep learning (DL) has achieved unprecedented success in numerous fields, such as computer vision and healthcare. Particularly, DL is experiencing an increasing development in advanced medical image analysis applications in terms of segmentation, classification, detection, and other tasks. On the one hand, tremendous needs that leverage DL's power for medical image analysis arise from the research community of a medical, clinical, and informatics background to share their knowledge, skills, and experience jointly. On the other hand, barriers between disciplines are on the road for them, often hampering a full and efficient collaboration. To this end, we propose our novel open-source platform, i.e., MEDAS-the MEDical open-source platform As Service. To the best of our knowledge, MEDAS is the first open-source platform providing collaborative and interactive services for researchers from a medical background using DL-related toolkits easily and for scientists or engineers from informatics modeling faster. Based on tools and utilities from the idea of RINV (Rapid Implementation aNd Verification), our proposed platform implements tools in pre-processing, post-processing, augmentation, visualization, and other phases needed in medical image analysis. Five tasks, concerning lung, liver, brain, chest, and pathology, are validated and demonstrated to be efficiently realizable by using MEDAS. MEDAS is available at http://medas.bnc.org.cn/.
ABSTRACT
Lung cancer is a life-threatening disease and its diagnosis is of great significance. Data scarcity and unavailability of datasets is a major bottleneck in lung cancer research. In this paper, we introduce a dataset of pulmonary lesions for designing the computer-aided diagnosis (CAD) systems. The dataset has fine contour annotations and nine attribute annotations. We define the structure of the dataset in detail, and then discuss the relationship of the attributes and pathology, and the correlation between the nine attributes with the chi-square test. To demonstrate the contribution of our dataset to computer-aided system design, we define four tasks that can be developed using our dataset. Then, we use our dataset to model multi-attribute classification tasks. We discuss the performance in 2D, 2.5D, and 3D input modes of the classification model. To improve performance, we introduce two attention mechanisms and verify the principles of the attention mechanisms through visualization. Experimental results show the relationship between different models and different levels of attributes.
