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1.
Clin Exp Dermatol ; 47(7): 1298-1306, 2022 Jul.
Article in English | MEDLINE | ID: mdl-35187683

ABSTRACT

BACKGROUND: Assessing the area involved in a skin disease, i.e. the body surface area (BSA), is essential in diagnosing disease severity, including in psoriasis. However, in psoriasis, BSA tends to be overestimated by physicians and has shown high inter-rater and intrarater variability. Furthermore, there are no reports suggesting the cause and clinical significance of overestimating BSA in psoriasiss. AIM: To investigate the errors in estimating BSA in psoriasis by comparing physicians' results with those of computer-assisted image analysis (CAIA) and to provide suggestions regarding the clinical implications of such errors. METHODS: Using 43 images, 36 physicians visually estimated BSA in psoriasis, and subsequently, the images were evaluated using a CAIA program (ImageJ); the BSA values determined by the physicians and CAIA were then compared and matched. The BSA percentage was also graded on a scale from 0 to 6, as follows: Grade 0 = no lesion, Grade 1 = 1%-9%, Grade 2 = 10%-29%, Grade 3 = 30%-49%, Grade 4 = 50%-69%, Grade 5 = 70%-89% and Grade 6 = 90%-100%. Each grade range was divided, with the bottom and top 50% defined as the 'first half' and 'second half,' respectively. RESULTS: The mean proportion of correct assessments by physicians was 49.4%. Physicians tended to overestimate the BSA of psoriatic lesions by 8.76% ± 8.82% compared with CAIA. The largest estimation error (proportion incorrect 75.7%) was observed in Grade 3 (30%-49% involvement). Estimates in the second half of the range demonstrated a higher proportion of inaccuracies compared with those in the first half. An overestimating error occurred in certain morphological characteristics of the psoriatic lesions. CONCLUSIONS: The inaccuracy of BSA estimation by physicians may be related to the fact that information from the human eye is perceived to be exaggerated compared with the actual size. Further research into using artificial intelligence technology is needed to reduce quantification error and develop an ideal BSA assessment system. Additionally, education and training are needed for physicians to measure BSA accurately.


Subject(s)
Physicians , Psoriasis , Artificial Intelligence , Body Surface Area , Humans , Image Processing, Computer-Assisted/methods , Psoriasis/diagnosis , Psoriasis/pathology , Reproducibility of Results , Severity of Illness Index
2.
Clin Dev Immunol ; 2010: 618517, 2010.
Article in English | MEDLINE | ID: mdl-21197410

ABSTRACT

Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical applications. To investigate the effect of hirsutenone (HIR), a diarylheptanoid compound, on AD-like skin lesions and other factors related to immune response is the aim of this paper Th2-related cytokines (IL-4, IL-5, IL-13), eosinophil, IgE inflammatory factors (COX-2, iNOS) levels were reduced in blood, lymphocytes, and tissue after HIR treatment. These results suggest that HIR might be an effective treatment for AD.


Subject(s)
Catechols/therapeutic use , Dermatitis, Atopic/drug therapy , Dermatitis, Atopic/pathology , Diarylheptanoids/therapeutic use , Skin/pathology , Administration, Cutaneous , Animals , Catechols/administration & dosage , Catechols/chemical synthesis , Cyclooxygenase 2/blood , Diarylheptanoids/administration & dosage , Diarylheptanoids/chemical synthesis , Diarylheptanoids/isolation & purification , Disease Models, Animal , Eosinophils/drug effects , Female , Immunoglobulin E/blood , Injections, Intraperitoneal , Interleukins/blood , Mice , Mice, Inbred Strains , Nitric Oxide Synthase Type II/blood
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