Effects of hierarchical nursing management in patients with acute pulmonary embolism.

BACKGROUND: Acute pulmonary embolism (acute PE) is the most serious manifestation of venous thromboembolism. Hierarchical nursing management is an improved option for nursing, but no study that indicated the effects of hierarchical nursing management in patients with acute PE could be found. This study aimed to explore the effects of hierarchical nursing management on the quality of nursing care and the prognosis of patients with acute PE. Methods From January 2020 to January 2022, 92 patients with acute PE were recruited and divided into the study group and the control group. The study group was designated with our hierarchical nursing care and the control group was designated with a conventional nursing care. The data of general characteristics, nursing quality, the improvement of clinical symptoms, the job satisfaction of nursing was collected and compared. Results The door-to-needle time, the thrombectomy time and length of emergency staying the study group were shorter than those in the control group (P < 0.005). The rate of complications in the study group was lower than that in the control group (P = 0.158). The scores of the nursing quality and the nursing satisfaction levels in the study group were remarkably higher than that in the control group. Conclusion For acute PE patients, the using of hierarchical nursing management can shorten the rescue time, reduce the rate of complications and improve the nursing quality of nursing care.

Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1.

Glucose and lipid metabolism disorder in diabetes mellitus often causes damage to multiple tissues and organs. Diabetes mellitus is beneficially affected by quercetin. However, its concrete mechanisms are yet to be fully elucidated. In our study, diabetes was induced in Sprague-Dawley rats by STZ injection. The rats were randomly divided into normal control, diabetic model, low-dose quercetin treatment, high-dose quercetin treatment, and pioglitazone treatment groups. Fasting blood glucose was collected to evaluate diabetes. Immunohistochemistry and fluorometric assay were performed to explore SIRT1. Akt levels were measured through immunoprecipitation and Western blot. After 12 weeks of quercetin treatment, the biochemical parameters of glucose and lipid metabolism improved to varying degrees. Hepatic histomorphological injury was alleviated, and hepatic glycogen content was increased. The expression and activity of hepatic SIRT1 were enhanced, and Akt was activated by phosphorylation and deacetylation. These results suggested that the beneficial effects of quercetin on glucose and lipid metabolism disorder are probably associated with the upregulated activity and protein level of SIRT1 and its influence on Akt signaling pathway. Hence, quercetin shows potential for the treatment of glucose and lipid metabolism disorder in diabetes mellitus.