Construction of urchin-like bimetallic phosphides induced by carbon dots for efficient wide pH hydrogen production.

The development of an efficient noble-metal-free and pH-universal electrocatalyst for the hydrogen evolution reaction (HER) would be highly significant for hydrogen (H2) production via electrocatalytic water splitting. However, developing such a catalyst remains a formidable task. Herein, a strategy is proposed for the in situ fabrication of a novel urchin-like NiCoP microsphere catalyst (0.5CDs-NiCoP/NF) on nickel foam (NF) using carbon dots (CDs) as a directing agent. The strong bonding between the CDs and metals provides additional active sites, giving 0.5CDs-NiCoP/NF excellent electrocatalytic hydrogen evolution performance in environments ranging from acidic to basic. Moreover, the unique structure of 0.5CDs-NiCoP/NF endows this catalyst with low Tafel slopes of 73, 146 and 74 mV dec-1 for HER in acidic, neutral and alkaline conditions, respectively. This performance exceeds that of numerous other reported non-precious HER catalysts. In summary, this work offers a novel and efficient strategy for the design and synthesis of low-cost, efficient, and robust transition metal phosphides (TMPs) electrocatalysts.

The role of long noncoding RNAs in liquid-liquid phase separation.

Long noncoding RNAs (lncRNAs), which are among the most well-characterized noncoding RNAs, have attracted much attention due to their regulatory functions and potential therapeutic options in many types of disease. Liquid-liquid phase separation (LLPS), the formation of droplet condensates, is involved in various cellular processes, but the molecular interactions of lncRNAs in LLPS are unclear. In this review, we describe the research development on LLPS, including descriptions of various methods established to identify LLPS, summarize the physiological and pathological functions of LLPS, identify the molecular interactions of lncRNAs in LLPS, and present the potential applications of leveraging LLPS in the clinic. The aim of this review is to update the knowledge on the association between LLPS and lncRNAs, which might provide a new direction for the treatment of LLPS-mediated disease.

Activating Innate Immunity by a STING Signal Amplifier for Local and Systemic Immunotherapy.

The number of patients who benefit from acquired immunotherapy is limited. Stimulator of interferon genes (STING) signal activation is a significant component to enhance innate immunity, which has been used to realize broad-spectrum immunotherapy. Here, M@P@HA nanoparticles, as a STING signal amplifier, are constructed to enhance innate immunotherapy. Briefly, when M@P@HA was targeted into tumor cells, the nanoparticles decomposed with Mn2+ and activated the release of protoporphyrin (PpIX). Under light irradiation, the generated reactive oxygen species disrupt the cellular redox homeostasis to lead cytoplasm leakage of damaged mitochondrial double-stranded (ds) DNA, which is the initiator of the STING signal. Simultaneously, Mn2+ as the immunoregulator could significantly increase the activity of related protein of a STING signal, such as cyclic GMP-AMP synthase (cGAS) and STING, to further amplify the STING signal of tumor cells. Subsequently, the STING signal of tumor-associated macrophages (TAM) is also activated by capturing dsDNA and Mn2+ that escaped from tumor cells, so as to enhance innate immunity. It is found that, by amplifying the STING signal of tumor tissue, M@P@HA could not only activate innate immunity but also cascade to activate CD8+ T cell infiltration even in a tumor with low immunogenicity.

The Abundance and Structure of Deadwood: A Comparison of Mixed and Thinned Chinese Fir Plantations.

The sustainability of coniferous monoculture plantations is facing challenges with respect to yields, ecology, and biodiversity. Conversion of monocultural coniferous plantations into mixed stands using thinning or direct mixed planting is widely considered to be a key strategy for overcoming these challenges and transforming the characteristics of plantations on a regional scale. Substantial amounts of deadwood may be produced in mixed forests (MFs); this material is important for evaluating and modifying forest management methods, understanding the dynamics of forest stands, and achieving biodiversity conservation. We assessed the quantitative characters and diameter distributions of deadwood in mixed and thinned Chinese fir [Cunninghamia lanceolata (Lamb.) Hook.] forests over one rotation. We used the g(r) function and spatial parameters to analyze the spatial structure of deadwood, and used logistic regression and Hegyi's competition index (HCI) to explore competition and mortality. Our results indicate that: (1) Chinese fir dominated in all groups of deadwood (snags, broken wood, and fallen wood), and the abundance, volume, and mortality rates of deadwood were much lower in the thinning forest compared to the MF. (2) Later coming populations (LCPs) comprised the majority of the small diameter classes in the thinning forest, but only accounted for a small proportion of the MF. (3) Broken wood in the thinning forest was randomly distributed, while the other types of deadwood were clustered at most spatial scales. In contrast, the spatial patterns in the MF were random at most spatial scales. (4) Total deadwood in both stands was in a status of intermediate and was randomly surrounded by its four nearest neighbors. All types of deadwood were highly mixed in the thinning forest and moderately mixed in the MF. Our case study suggests that thinning and mixing result in different stand development processes and thus influence the type, amount, and structure of deadwood. Thinning significantly reduces competition, which is the main driver of tree mortality. Converting pure Chinese fir plantations into mixed stands by thinning should be taken in future. Understanding tree mortality after conversion is essential to select appropriate silvicultural treatments and achieve ultimately sustainable forest management.